Sequence Detail

ID/Version

E9Q555 Q8BVK6 F7A6H4 (UniProt | EBI)

Last sequence update: 2021-09-29
Last annotation update: 2024-01-24

Sequence description from provider

RecName: Full=E3 ubiquitin-protein ligase RNF213; EC=2.3.2.27 {ECO:0000250|UniProtKB:Q63HN8}; EC=3.6.4.- {ECO:0000269|PubMed:32573437};AltName: Full=E3 ubiquitin-lipopolysaccharide ligase RNF213 {ECO:0000305}; EC=2.3.2.- {ECO:00002

Provider

SWISS-PROT

Sequence

Polypeptide 5148 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Rnf213	ring finger protein 213	47	98	3	14

Sequence references in MGI

J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:200802 Kobayashi H, et al., Ablation of Rnf213 retards progression of diabetes in the Akita mouse. Biochem Biophys Res Commun. 2013 Mar 15;432(3):519-25
J:227953 Sonobe S, et al., Temporal profile of the vascular anatomy evaluated by 9.4-T magnetic resonance angiography and histopathological analysis in mice lacking RNF213: a susceptibility gene for moyamoya disease. Brain Res. 2014 Mar 13;1552:64-71
J:228851 Sonobe S, et al., Increased vascular MMP-9 in mice lacking RNF213: moyamoya disease susceptibility gene. Neuroreport. 2014 Dec 17;25(18):1442-6
J:229327 Kobayashi H, et al., Biochemical and Functional Characterization of RNF213 (Mysterin) R4810K, a Susceptibility Mutation of Moyamoya Disease, in Angiogenesis In Vitro and In Vivo. J Am Heart Assoc. 2015 Jul;4(7)
J:229422 Kanoke A, et al., Temporal profile of the vascular anatomy evaluated by 9.4-tesla magnetic resonance angiography and histological analysis in mice with the R4859K mutation of RNF213, the susceptibility gene for moyamoya disease. Brain Res. 2015 Oct 22;1624:497-505
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89
J:308425 Houzelstein D, et al., The ring finger protein 213 gene (Rnf213) contributes to Rift Valley fever resistance in mice. Mamm Genome. 2021 Feb;32(1):30-37
J:308514 Ahel J, et al., Moyamoya disease factor RNF213 is a giant E3 ligase with a dynein-like core and a distinct ubiquitin-transfer mechanism. Elife. 2020 Jun 23;9:e56185
J:313855 Otten EG, et al., Ubiquitylation of lipopolysaccharide by RNF213 during bacterial infection. Nature. 2021 Jun;594(7861):111-116