Sequence Detail

ID/Version

E9Q401 Q62174 O70181 Q62197 Q9ERN6 (UniProt | EBI)

Last sequence update: 2011-04-05
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=Ryanodine receptor 2 {ECO:0000305|PubMed:10473538}; Short=RYR-2; Short=RyR2;AltName: Full=Cardiac muscle ryanodine receptor;AltName: Full=Cardiac muscle ryanodine receptor-calcium release channel;AltName: Full=Type 2 ryanodin

Provider

SWISS-PROT

Sequence

Polypeptide 4966 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Ryr2	ryanodine receptor 2, cardiac	172	132	4	55

Sequence references in MGI

J:23314 Giannini G, et al., The ryanodine receptor/calcium channel genes are widely and differentially expressed in murine brain and peripheral tissues. J Cell Biol. 1995 Mar;128(5):893-904
J:26886 Takeshima H, et al., Ca(2+)-induced Ca2+ release in myocytes from dyspedic mice lacking the type-1 ryanodine receptor. EMBO J. 1995 Jul 3;14(13):2999-3006
J:48277 Takeshima H, et al., Embryonic lethality and abnormal cardiac myocytes in mice lacking ryanodine receptor type 2. EMBO J. 1998 Jun 15;17(12):3309-16
J:57615 Zhao M, et al., Molecular identification of the ryanodine receptor pore-forming segment. J Biol Chem. 1999 Sep 10;274(37):25971-4
J:120848 Anyatonwu GI, et al., Regulation of ryanodine receptor-dependent calcium signaling by polycystin-2. Proc Natl Acad Sci U S A. 2007 Apr 10;104(15):6454-9
J:179475 van Oort RJ, et al., Ryanodine receptor phosphorylation by calcium/calmodulin-dependent protein kinase II promotes life-threatening ventricular arrhythmias in mice with heart failure. Circulation. 2010 Dec 21;122(25):2669-79
J:262362 Benson MA, et al., Ryanodine receptors are part of the myospryn complex in cardiac muscle. Sci Rep. 2017 Jul 24;7(1):6312
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89
J:302151 Sun B, et al., Cardiac ryanodine receptor calcium release deficiency syndrome. Sci Transl Med. 2021 Feb 3;13(579)