Sequence Detail

ID/Version

E9PY61 (UniProt | EBI)

Last sequence update: 2011-04-05
Last annotation update: 2024-01-24

Sequence description from provider

RecName: Full=G-protein coupled receptor 179 {ECO:0000305};Flags: Precursor;

Provider

SWISS-PROT

Sequence

Polypeptide 2293 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Gpr179	G protein-coupled receptor 179	11	97	3	9

Sequence references in MGI

J:185272 Orlandi C, et al., GPR158/179 regulate G protein signaling by controlling localization and activity of the RGS7 complexes. J Cell Biol. 2012 Jun 11;197(6):711-9
J:185567 Peachey NS, et al., GPR179 is required for depolarizing bipolar cell function and is mutated in autosomal-recessive complete congenital stationary night blindness. Am J Hum Genet. 2012 Feb 10;90(2):331-9
J:211063 Ray TA, et al., GPR179 is required for high sensitivity of the mGluR6 signaling cascade in depolarizing bipolar cells. J Neurosci. 2014 Apr 30;34(18):6334-43
J:211946 Balmer J, et al., Presence of the Gpr179(nob5) allele in a C3H-derived transgenic mouse. Mol Vis. 2013;19:2615-25
J:214871 Orlandi C, et al., Orphan receptor GPR179 forms macromolecular complexes with components of metabotropic signaling cascade in retina ON-bipolar neurons. Invest Ophthalmol Vis Sci. 2013;54(10):7153-61
J:214877 Klooster J, et al., Ultrastructural localization of GPR179 and the impact of mutant forms on retinal function in CSNB1 patients and a mouse model. Invest Ophthalmol Vis Sci. 2013;54(10):6973-81
J:219703 Nishiguchi KM, et al., Gene therapy restores vision in rd1 mice after removal of a confounding mutation in Gpr179. Nat Commun. 2015;6:6006
J:269858 Orlandi C, et al., Transsynaptic Binding of Orphan Receptor GPR179 to Dystroglycan-Pikachurin Complex Is Essential for the Synaptic Organization of Photoreceptors. Cell Rep. 2018 Oct 2;25(1):130-145.e5
J:308356 Orhan E, et al., A New Mouse Model for Complete Congenital Stationary Night Blindness Due to Gpr179 Deficiency. Int J Mol Sci. 2021 Apr 23;22(9)
J:340157 Wilmet B, et al., Mice Lacking Gpr179 with Complete Congenital Stationary Night Blindness Are a Good Model for Myopia. Int J Mol Sci. 2022 Dec 22;24(1)