Sequence Detail

ID/Version

E9PVA8 B2RWW6 (UniProt | EBI)

Last sequence update: 2011-04-05
Last annotation update: 2024-03-27

Sequence description from provider

RecName: Full=Stalled ribosome sensor GCN1 {ECO:0000305};AltName: Full=GCN1 eIF-2-alpha kinase activator homolog {ECO:0000250|UniProtKB:Q92616};AltName: Full=GCN1-like protein 1 {ECO:0000312|MGI:MGI:2444248};AltName: Full=General control of amino-acid syn

Provider

SWISS-PROT

Sequence

Polypeptide 2671 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Gcn1	GCN1 activator of EIF2AK4	20	99	3	53

Sequence references in MGI

J:100824 Pereira CM, et al., IMPACT, a protein preferentially expressed in the mouse brain, binds GCN1 and inhibits GCN2 activation. J Biol Chem. 2005 Aug 5;280(31):28316-23
J:197824 Roffe M, et al., IMPACT is a developmentally regulated protein in neurons that opposes the eukaryotic initiation factor 2alpha kinase GCN2 in the modulation of neurite outgrowth. J Biol Chem. 2013 Apr 12;288(15):10860-9
J:211861 Cambiaghi TD, et al., Evolutionarily conserved IMPACT impairs various stress responses that require GCN1 for activating the eIF2 kinase GCN2. Biochem Biophys Res Commun. 2014 Jan 10;443(2):592-7
J:227376 Waller T, et al., Evidence that Yih1 resides in a complex with ribosomes. FEBS J. 2012 May;279(10):1761-76
J:287528 Yamazaki H, et al., Ribosome binding protein GCN1 regulates the cell cycle and cell proliferation and is essential for the embryonic development of mice. PLoS Genet. 2020 Apr;16(4):e1008693
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89
J:337230 Liu J, et al., Inducible Systemic Gcn1 Deletion in Mice Leads to Transient Body Weight Loss upon Tamoxifen Treatment Associated with Decrease of Fat and Liver Glycogen Storage. Int J Mol Sci. 2022 Mar 16;23(6)