Sequence Detail

ID/Version

E1AZ71 (UniProt | EBI)

Last sequence update: 2010-11-02
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=Cyclic nucleotide-gated channel beta-1;AltName: Full=Cyclic nucleotide-gated cation channel 4; Short=CNG channel 4; Short=CNG-4; Short=CNG4 {ECO:0000303|PubMed:11764791};

Provider

SWISS-PROT

Sequence

Polypeptide 1325 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Cngb1	cyclic nucleotide gated channel beta 1	30	99	3	14

Sequence references in MGI

J:86879 Bradley J, et al., Nomenclature for ion channel subunits. Science. 2001 Dec 7;294(5549):2095-6
J:95768 Huttl S, et al., Impaired channel targeting and retinal degeneration in mice lacking the cyclic nucleotide-gated channel subunit CNGB1. J Neurosci. 2005 Jan 5;25(1):130-8
J:117253 Michalakis S, et al., Loss of CNGB1 protein leads to olfactory dysfunction and subciliary cyclic nucleotide-gated channel trapping. J Biol Chem. 2006 Nov 17;281(46):35156-66
J:150504 Zhang Y, et al., Knockout of GARPs and the beta-subunit of the rod cGMP-gated channel disrupts disk morphogenesis and rod outer segment structural integrity. J Cell Sci. 2009 Apr 15;122(Pt 8):1192-200
J:187751 Koch S, et al., Gene therapy restores vision and delays degeneration in the CNGB1-/- mouse model of retinitis pigmentosa. Hum Mol Genet. 2012 Oct 15;21(20):4486-96