Sequence Detail

ID/Version

E0CZ16 F7A5U9 I6L891 (UniProt | EBI)

Last sequence update: 2012-05-16
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=Kelch-like protein 3 {ECO:0000303|PubMed:22266938};

Provider

SWISS-PROT

Sequence

Polypeptide 587 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Klhl3	kelch-like 3	33	97	3	16

Sequence references in MGI

J:214330 Susa K, et al., Impaired degradation of WNK1 and WNK4 kinases causes PHAII in mutant KLHL3 knock-in mice. Hum Mol Genet. 2014 Oct 1;23(19):5052-60
J:216684 Shibata S, et al., Angiotensin II signaling via protein kinase C phosphorylates Kelch-like 3, preventing WNK4 degradation. Proc Natl Acad Sci U S A. 2014 Oct 28;111(43):15556-61
J:220813 Gong Y, et al., KLHL3 regulates paracellular chloride transport in the kidney by ubiquitination of claudin-8. Proc Natl Acad Sci U S A. 2015 Apr 7;112(14):4340-5
J:244278 Sasaki E, et al., KLHL3 Knockout Mice Reveal the Physiological Role of KLHL3 and the Pathophysiology of Pseudohypoaldosteronism Type II Caused by Mutant KLHL3. Mol Cell Biol. 2017 Apr 01;37(7)
J:335611 Lin CM, et al., Generation and analysis of pseudohypoaldosteronism type II knock-in mice caused by a nonsense KLHL3 mutation in the Kelch domain. FASEB J. 2022 Jun;36(6):e22363