Sequence Detail

ID/Version

D3Z7P3 Q69ZX9 E9PUF0 (UniProt | EBI)

Last sequence update: 2010-04-20
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=Glutaminase kidney isoform, mitochondrial; Short=GLS; EC=3.5.1.2 {ECO:0000269|PubMed:22228304, ECO:0000269|PubMed:23935106, ECO:0000269|PubMed:27542409};Contains: RecName: Full=Glutaminase kidney isoform, mitochondrial 68 kD

Provider

SWISS-PROT

Sequence

Polypeptide 674 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Gls	glutaminase	36	103	4	16

Sequence references in MGI

J:92575 Okazaki N, et al., Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. DNA Res. 2004 Jun 30;11(3):205-18
J:108409 Masson J, et al., Mice lacking brain/kidney phosphate-activated glutaminase have impaired glutamatergic synaptic transmission, altered breathing, disorganized goal-directed behavior and die shortly after birth. J Neurosci. 2006 Apr 26;26(17):4660-71
J:111737 Buschdorf JP, et al., Brain-specific BNIP-2-homology protein Caytaxin relocalises glutaminase to neurite terminals and reduces glutamate levels. J Cell Sci. 2006 Aug 15;119(Pt 16):3337-50
J:184098 Cassago A, et al., Mitochondrial localization and structure-based phosphate activation mechanism of Glutaminase C with implications for cancer metabolism. Proc Natl Acad Sci U S A. 2012 Jan 24;109(4):1092-7
J:203468 Park J, et al., SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways. Mol Cell. 2013 Jun 27;50(6):919-30
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89