Sequence Detail

ID/Version

D2J0Y4 (UniProt | EBI)

Last sequence update: 2010-02-09
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=(E2-independent) E3 ubiquitin-conjugating enzyme FATS {ECO:0000305}; EC=2.3.2.- {ECO:0000269|PubMed:24240685};AltName: Full=Centrosomal protein C10orf90 homolog {ECO:0000305};AltName: Full=E2/E3 hybrid ubiquitin-protein ligase FATS {

Provider

SWISS-PROT

Sequence

Polypeptide 644 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	D7Ertd443e	DNA segment, Chr 7, ERATO Doi 443, expressed	25	96	3	7

Sequence references in MGI

J:160788 Li Z, et al., An HDAC1-binding domain within FATS bridges p21 turnover to radiation-induced tumorigenesis. Oncogene. 2010 May 6;29(18):2659-71
J:175329 Zhang X, et al., FATS is a transcriptional target of p53 and associated with antitumor activity. Mol Cancer. 2010;9:244
J:265621 Yan S, et al., FATS is an E2-independent ubiquitin ligase that stabilizes p53 and promotes its activation in response to DNA damage. Oncogene. 2014 Nov 20;33(47):5424-33