Sequence Detail

ID/Version

O70507 B2RY58 (UniProt | EBI)

Last sequence update: 2024-10-02
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4;AltName: Full=Brain cyclic nucleotide-gated channel 3; Short=BCNG-3;

Provider

SWISS-PROT

Sequence

Polypeptide 1201 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Hcn4	hyperpolarization-activated, cyclic nucleotide-gated K+ 4	65	133	4	16

Sequence references in MGI

J:47845 Santoro B, et al., Identification of a gene encoding a hyperpolarization-activated pacemaker channel of brain. Cell. 1998 May 29;93(5):717-29
J:86988 Stieber J, et al., The hyperpolarization-activated channel HCN4 is required for the generation of pacemaker action potentials in the embryonic heart. Proc Natl Acad Sci U S A. 2003 Dec 9;100(25):15235-40
J:168248 Baruscotti M, et al., Deep bradycardia and heart block caused by inducible cardiac-specific knockout of the pacemaker channel gene Hcn4. Proc Natl Acad Sci U S A. 2011 Jan 25;108(4):1705-10
J:292477 Peters CH, et al., Isoform-specific regulation of HCN4 channels by a family of endoplasmic reticulum proteins. Proc Natl Acad Sci U S A. 2020 Jul 28;117(30):18079-18090
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89