Sequence Detail

ID/Version

Q8BYC6 Q3V3B3 B2RY27 (UniProt | EBI)

Last sequence update: 2005-10-25
Last annotation update: 2025-06-18

Sequence description from provider

RecName: Full=Serine/threonine-protein kinase TAO3; EC=2.7.11.1;AltName: Full=Thousand and one amino acid protein 3;

Provider

SWISS-PROT

Sequence

Polypeptide 898 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Taok3	TAO kinase 3	45	98	4	23

Sequence references in MGI

J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:143718 Trost M, et al., The phagosomal proteome in interferon-gamma-activated macrophages. Immunity. 2009 Jan;30(1):143-54
J:203468 Park J, et al., SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways. Mol Cell. 2013 Jun 27;50(6):919-30
J:264707 Hammad H, et al., Transitional B cells commit to marginal zone B cell fate by Taok3-mediated surface expression of ADAM10. Nat Immunol. 2017 Mar;18(3):313-320
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89
J:298569 Vanderkerken M, et al., TAO-kinase 3 governs the terminal differentiation of NOTCH2-dependent splenic conventional dendritic cells. Proc Natl Acad Sci U S A. 2020 Dec 8;117(49):31331-31342
J:303290 Li Z, et al., TAOK3 is a MAP3K contributing to osteoblast differentiation and skeletal mineralization. Biochem Biophys Res Commun. 2020 Oct 22;531(4):497-502
J:313593 Maes B, et al., The STE20 kinase TAOK3 controls the development house dust mite-induced asthma in mice. J Allergy Clin Immunol. 2021 Sep 8;
J:337863 Poirier A, et al., TAOK3 limits age-associated inflammation by negatively modulating macrophage differentiation and their production of TNFalpha. Immun Ageing. 2023 Jul 3;20(1):31
J:338082 Maes B, et al., STE20 kinase TAOK3 regulates type 2 immunity and metabolism in obesity. J Exp Med. 2023 Sep 4;220(9)
J:344224 Poirier A, et al., The induction of SHP-1 degradation by TAOK3 ensures the responsiveness of T cells to TCR stimulation. Sci Signal. 2024 Jan 2;17(817):eadg4422