Sequence Detail

ID/Version

P97433 B2RQQ2 Q69Z41 A0PJC1 Q6DI55 G5E8P2 (UniProt | EBI)

Last sequence update: 2022-10-12
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=Rho guanine nucleotide exchange factor 28;AltName: Full=190 kDa guanine nucleotide exchange factor; Short=p190-RhoGEF; Short=p190RhoGEF;AltName: Full=Rho guanine nucleotide exchange factor;AltName: Full=Rho-interacting protei

Provider

SWISS-PROT

Sequence

Polypeptide 1700 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Arhgef28	Rho guanine nucleotide exchange factor 28	20	100	3	11

Sequence references in MGI

J:55203 Gebbink MF, et al., Identification of a novel, putative Rho-specific GDP/GTP exchange factor and a RhoA-binding protein: control of neuronal morphology. J Cell Biol. 1997 Jun 30;137(7):1603-13
J:58705 Meyer D, et al., Interaction of c-Jun amino-terminal kinase interacting protein-1 with p190 rhoGEF and its localization in differentiated neurons. J Biol Chem. 1999 Dec 3;274(49):35113-8
J:92575 Okazaki N, et al., Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. DNA Res. 2004 Jun 30;11(3):205-18
J:93215 Rico B, et al., Control of axonal branching and synapse formation by focal adhesion kinase. Nat Neurosci. 2004 Oct;7(10):1059-1069
J:106807 Lin H, et al., RNA-binding protein is involved in aggregation of light neurofilament protein and is implicated in the pathogenesis of motor neuron degeneration. Hum Mol Genet. 2005 Dec 1;14(23):3643-59
J:113594 Zhai J, et al., Direct interaction of focal adhesion kinase with p190RhoGEF. J Biol Chem. 2003 Jul 4;278(27):24865-73
J:114700 van Horck FP, et al., Characterization of p190RhoGEF, a RhoA-specific guanine nucleotide exchange factor that interacts with microtubules. J Biol Chem. 2001 Feb 16;276(7):4948-56
J:230375 Zhai J, et al., Identification of a novel interaction of 14-3-3 with p190RhoGEF. J Biol Chem. 2001 Nov 2;276(44):41318-24
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89