Sequence Detail

ID/Version

A4Q9E8 B2RQS4 Q3UL10 Q8BVQ1 A2A6M6 (UniProt | EBI)

Last sequence update: 2007-05-15
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=Tubulin polyglutamylase TTLL6 {ECO:0000303|PubMed:17499049}; EC=6.3.2.- {ECO:0000269|PubMed:17499049, ECO:0000269|PubMed:20530212, ECO:0000269|PubMed:21074048, ECO:0000269|PubMed:26829768, ECO:0000269|PubMed:32747782};AltName: Full=P

Provider

SWISS-PROT

Sequence

Polypeptide 822 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Ttll6	tubulin tyrosine ligase-like family, member 6	37	100	3	20

Sequence references in MGI

J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:130247 van Dijk J, et al., A targeted multienzyme mechanism for selective microtubule polyglutamylation. Mol Cell. 2007 May 11;26(3):437-48
J:162689 Lacroix B, et al., Tubulin polyglutamylation stimulates spastin-mediated microtubule severing. J Cell Biol. 2010 Jun 14;189(6):945-54
J:166837 Rogowski K, et al., A family of protein-deglutamylating enzymes associated with neurodegeneration. Cell. 2010 Nov 12;143(4):564-78
J:181179 Lee JE, et al., CEP41 is mutated in Joubert syndrome and is required for tubulin glutamylation at the cilium. Nat Genet. 2012 Feb;44(2):193-9
J:201638 Bosch Grau M, et al., Tubulin glycylases and glutamylases have distinct functions in stabilization and motility of ependymal cilia. J Cell Biol. 2013 Aug 5;202(3):441-51
J:231311 Xia P, et al., Glutamylation of the DNA sensor cGAS regulates its binding and synthase activity in antiviral immunity. Nat Immunol. 2016 Apr;17(4):369-78
J:297726 Mahalingan KK, et al., Structural basis for polyglutamate chain initiation and elongation by TTLL family enzymes. Nat Struct Mol Biol. 2020 Sep;27(9):802-813