Sequence Detail

ID/Version

A2ASQ1 A2ASP9 A2ASQ0 B2RWU1 (UniProt | EBI)

Last sequence update: 2007-02-20
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=Agrin;Contains: RecName: Full=Agrin N-terminal 110 kDa subunit;Contains: RecName: Full=Agrin C-terminal 110 kDa subunit;Contains: RecName: Full=Agrin C-terminal 90 kDa fragment; Short=C90;Contains: RecName: Full=Agrin C-termina

Provider

SWISS-PROT

Sequence

Polypeptide 1950 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Agrn	agrin	94	138	3	50

Sequence references in MGI

J:33184 Glass DJ, et al., Agrin acts via a MuSK receptor complex. Cell. 1996 May 17;85(4):513-23
J:42277 Smith MA, et al., Selective regulation of agrin mRNA induction and alternative splicing in PC12 cells by Ras-dependent actions of nerve growth factor. J Biol Chem. 1997 Jun 20;272(25):15675-81
J:55407 Burgess RW, et al., Alternatively spliced isoforms of nerve- and muscle-derived agrin: their roles at the neuromuscular junction. Neuron. 1999 May;23(1):33-44
J:64996 Burgess RW, et al., Agrin isoforms with distinct amino termini. Differential expression, localization, and function. J Cell Biol. 2000 Oct 2;151(1):41-52
J:122932 Ksiazek I, et al., Synapse loss in cortex of agrin-deficient mice after genetic rescue of perinatal death. J Neurosci. 2007 Jul 4;27(27):7183-95
J:136579 Stephan A, et al., Neurotrypsin cleaves agrin locally at the synapse. FASEB J. 2008 Jun;22(6):1861-73
J:146801 Ruggiu M, et al., Rescuing Z+ agrin splicing in Nova null mice restores synapse formation and unmasks a physiologic defect in motor neuron firing. Proc Natl Acad Sci U S A. 2009 Mar 3;106(9):3513-8
J:148709 Matsumoto-Miyai K, et al., Coincident pre- and postsynaptic activation induces dendritic filopodia via neurotrypsin-dependent agrin cleavage. Cell. 2009 Mar 20;136(6):1161-71
J:176117 Bogdanik LP, et al., A valid mouse model of AGRIN-associated congenital myasthenic syndrome. Hum Mol Genet. 2011 Dec 1;20(23):4617-33
J:178376 Butikofer L, et al., Destabilization of the neuromuscular junction by proteolytic cleavage of agrin results in precocious sarcopenia. FASEB J. 2011 Dec;25(12):4378-93
J:263376 Trinidad JC, et al., Comprehensive identification of phosphorylation sites in postsynaptic density preparations. Mol Cell Proteomics. 2006 May;5(5):914-22
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89