Sequence Detail

ID/Version

A2ARV4 Q3TL35 Q9JLB3 P70215 (UniProt | EBI)

Last sequence update: 2007-02-20
Last annotation update: 2024-03-27

Sequence description from provider

RecName: Full=Low-density lipoprotein receptor-related protein 2; Short=LRP-2;AltName: Full=Glycoprotein 330; Short=gp330;AltName: Full=Megalin;Flags: Precursor;

Provider

SWISS-PROT

Sequence

Polypeptide 4660 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Lrp2	low density lipoprotein receptor-related protein 2	114	133	4	34

Sequence references in MGI

J:53162 Nykjaer A, et al., An endocytic pathway essential for renal uptake and activation of the steroid 25-(OH) vitamin D3. Cell. 1999 Feb 19;96(4):507-15
J:67664 Hammad SM, et al., Megalin acts in concert with cubilin to mediate endocytosis of high density lipoproteins. J Biol Chem. 2000 Apr 21;275(16):12003-8
J:95319 Spoelgen R, et al., LRP2/megalin is required for patterning of the ventral telencephalon. Development. 2005 Jan;132(2):405-14
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:104065 Faber K, et al., Megalin is a receptor for apolipoprotein M, and kidney-specific megalin-deficiency confers urinary excretion of apolipoprotein M. Mol Endocrinol. 2006 Jan;20(1):212-8
J:108391 Gonzalez-Villalobos R, et al., Megalin binds and internalizes angiotensin-(1-7). Am J Physiol Renal Physiol. 2006 May;290(5):F1270-5
J:115189 Hammes A, et al., Role of endocytosis in cellular uptake of sex steroids. Cell. 2005 Sep 9;122(5):751-62
J:121774 Kaseda R, et al., Megalin-mediated endocytosis of cystatin C in proximal tubule cells. Biochem Biophys Res Commun. 2007 Jun 15;357(4):1130-4
J:133662 Olson GE, et al., Megalin mediates selenoprotein P uptake by kidney proximal tubule epithelial cells. J Biol Chem. 2008 Mar 14;283(11):6854-60
J:134797 Konig O, et al., Estrogen and the inner ear: megalin knockout mice suffer progressive hearing loss. FASEB J. 2008 Feb;22(2):410-7
J:171318 Alvira-Botero X, et al., Megalin interacts with APP and the intracellular adapter protein FE65 in neurons. Mol Cell Neurosci. 2010 Nov;45(3):306-15
J:181474 Christ A, et al., LRP2 Is an Auxiliary SHH Receptor Required to Condition the Forebrain Ventral Midline for Inductive Signals. Dev Cell. 2012 Feb 14;22(2):268-78
J:183783 Ortega MC, et al., Megalin mediates the influence of sonic hedgehog on oligodendrocyte precursor cell migration and proliferation during development. Glia. 2012 May;60(6):851-66
J:188910 Morris SM, et al., Disabled-2 colocalizes with the LDLR in clathrin-coated pits and interacts with AP-2. Traffic. 2001 Feb;2(2):111-23
J:200932 Jobst-Schwan T, et al., Renal uptake of the antiapoptotic protein survivin is mediated by megalin at the apical membrane of the proximal tubule. Am J Physiol Renal Physiol. 2013 Sep;305(5):F734-44
J:214694 Kur E, et al., LRP2 mediates folate uptake in the developing neural tube. J Cell Sci. 2014 May 15;127(Pt 10):2261-8
J:231312 Baardman ME, et al., Common arterial trunk and ventricular non-compaction in Lrp2 knockout mice indicate a crucial role of LRP2 in cardiac development. Dis Model Mech. 2016 Apr 1;9(4):413-25
J:239874 Christ A, et al., LRP2 Acts as SHH Clearance Receptor to Protect the Retinal Margin from Mitogenic Stimuli. Dev Cell. 2015 Oct 12;35(1):36-48
J:243398 Gajera CR, et al., LRP2 in ependymal cells regulates BMP signaling in the adult neurogenic niche. J Cell Sci. 2010 Jun 01;123(Pt 11):1922-30
J:243406 Gburek J, et al., Renal uptake of myoglobin is mediated by the endocytic receptors megalin and cubilin. Am J Physiol Renal Physiol. 2003 Sep;285(3):F451-8
J:243418 Johanns M, et al., Cellular uptake of proMMP-2:TIMP-2 complexes by the endocytic receptor megalin/LRP-2. Sci Rep. 2017 Jun 28;7(1):4328
J:248445 McCarthy RA, et al., Megalin functions as an endocytic sonic hedgehog receptor. J Biol Chem. 2002 Jul 12;277(28):25660-7
J:251304 Hirano M, et al., N-Glycoform-dependent interactions of megalin with its ligands. Biochim Biophys Acta. 2017 Jan;1861(1 Pt A):3106-3118
J:273590 Muramatsu H, et al., LDL receptor-related protein as a component of the midkine receptor. Biochem Biophys Res Commun. 2000 Apr 21;270(3):936-41
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89