Sequence Detail

ID/Version

A2ALV5 (UniProt | EBI)

Last sequence update: 2007-02-20
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=Protein shortage in chiasmata 1 ortholog {ECO:0000305}; EC=3.6.-.- {ECO:0000250|UniProtKB:Q5VXU9};AltName: Full=Protein ZIP2 homolog {ECO:0000303|PubMed:30272023}; Short=MZip2 {ECO:0000303|PubMed:30272023};

Provider

SWISS-PROT

Sequence

Polypeptide 1481 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Shoc1	shortage in chiasmata 1	22	96	2	11

Sequence references in MGI

J:262079 Guiraldelli MF, et al., SHOC1 is a ERCC4-(HhH)2-like protein, integral to the formation of crossover recombination intermediates during mammalian meiosis. PLoS Genet. 2018 May;14(5):e1007381
J:268520 Zhang Q, et al., Evolutionarily-conserved MZIP2 is essential for crossover formation in mammalian meiosis. Commun Biol. 2018;1:147
J:297328 Zhang Q, et al., SPO16 binds SHOC1 to promote homologous recombination and crossing-over in meiotic prophase I. Sci Adv. 2019 Jan;5(1):eaau9780
J:331352 Wang W, et al., Bi-allelic variants in SHOC1 cause non-obstructive azoospermia with meiosis arrest in humans and mice. Mol Hum Reprod. 2022 May 27;28(6)