Sequence Detail

ID/Version

A2AIV8 (UniProt | EBI)

Last sequence update: 2007-02-20
Last annotation update: 2024-01-24

Sequence description from provider

RecName: Full=Caspase recruitment domain-containing protein 9 {ECO:0000303|PubMed:16862125};

Provider

SWISS-PROT

Sequence

Polypeptide 536 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Card9	caspase recruitment domain family, member 9	69	96	3	12

Sequence references in MGI

J:111706 Gross O, et al., Card9 controls a non-TLR signalling pathway for innate anti-fungal immunity. Nature. 2006 Aug 10;442(7103):651-6
J:117799 Hsu YM, et al., The adaptor protein CARD9 is required for innate immune responses to intracellular pathogens. Nat Immunol. 2007 Feb;8(2):198-205
J:122394 Hara H, et al., The adaptor protein CARD9 is essential for the activation of myeloid cells through ITAM-associated and Toll-like receptors. Nat Immunol. 2007 Jun;8(6):619-29
J:122424 Leibundgut-Landmann S, et al., Syk- and CARD9-dependent coupling of innate immunity to the induction of T helper cells that produce interleukin 17. Nat Immunol. 2007 Jun;8(6):630-638
J:166191 Bi L, et al., CARD9 mediates dectin-2-induced IkappaBalpha kinase ubiquitination leading to activation of NF-kappaB in response to stimulation by the hyphal form of Candida albicans. J Biol Chem. 2010 Aug 20;285(34):25969-77
J:181290 Strasser D, et al., Syk kinase-coupled C-type lectin receptors engage protein kinase C-sigma to elicit Card9 adaptor-mediated innate immunity. Immunity. 2012 Jan 27;36(1):32-42
J:209436 Yamamoto H, et al., Defect of CARD9 leads to impaired accumulation of gamma interferon-producing memory phenotype T cells in lungs and increased susceptibility to pulmonary infection with Cryptococcus neoformans. Infect Immun. 2014 Apr;82(4):1606-15
J:213863 Parkhouse R, et al., Interaction between NOD2 and CARD9 involves the NOD2 NACHT and the linker region between the NOD2 CARDs and NACHT domain. FEBS Lett. 2014 Aug 25;588(17):2830-6
J:218677 Jia XM, et al., CARD9 mediates Dectin-1-induced ERK activation by linking Ras-GRF1 to H-Ras for antifungal immunity. J Exp Med. 2014 Oct 20;211(11):2307-21
J:239728 Lamas B, et al., CARD9 impacts colitis by altering gut microbiota metabolism of tryptophan into aryl hydrocarbon receptor ligands. Nat Med. 2016 Jun;22(6):598-605
J:248085 Drummond RA, et al., CARD9-Dependent Neutrophil Recruitment Protects against Fungal Invasion of the Central Nervous System. PLoS Pathog. 2015 Dec;11(12):e1005293
J:248535 Jhingran A, et al., Compartment-specific and sequential role of MyD88 and CARD9 in chemokine induction and innate defense during respiratory fungal infection. PLoS Pathog. 2015 Jan;11(1):e1004589
J:259378 Wang X, et al., Impaired Specific Antifungal Immunity in CARD9-Deficient Patients with Phaeohyphomycosis. J Invest Dermatol. 2018 Mar;138(3):607-617
J:291457 Campuzano A, et al., CARD9-Associated Dectin-1 and Dectin-2 Are Required for Protective Immunity of a Multivalent Vaccine against Coccidioides posadasii Infection. J Immunol. 2020 Jun 15;204(12):3296-3306
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89
J:304208 Sokol H, et al., Card9 mediates intestinal epithelial cell restitution, T-helper 17 responses, and control of bacterial infection in mice. Gastroenterology. 2013 Sep;145(3):591-601.e3
J:306002 Doron I, et al., Human gut mycobiota tune immunity via CARD9-dependent induction of anti-fungal IgG antibodies. Cell. 2021 Feb 18;184(4):1017-1031.e14