Sequence Detail

ID/Version

A2AI08 Q8R1G4 Q8BNM5 Q7TNG3 Q3TMR8 Q3TAJ8 Q5FWB3 (UniProt | EBI)

Last sequence update: 2007-02-20
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=Taperin;

Provider

SWISS-PROT

Sequence

Polypeptide 749 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Tprn	taperin	43	98	3	8

Sequence references in MGI

J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:143718 Trost M, et al., The phagosomal proteome in interferon-gamma-activated macrophages. Immunity. 2009 Jan;30(1):143-54
J:158775 Rehman AU, et al., Targeted capture and next-generation sequencing identifies C9orf75, encoding taperin, as the mutated gene in nonsyndromic deafness DFNB79. Am J Hum Genet. 2010 Mar 12;86(3):378-88
J:158776 Li Y, et al., Mutations in TPRN cause a progressive form of autosomal-recessive nonsyndromic hearing loss. Am J Hum Genet. 2010 Mar 12;86(3):479-84
J:240563 Chen M, et al., Progressive hearing loss and degeneration of hair cell stereocilia in taperin gene knockout mice. Biochem Biophys Res Commun. 2016 Oct 28;479(4):703-707
J:271271 Liu C, et al., GRXCR2 Regulates Taperin Localization Critical for Stereocilia Morphology and Hearing. Cell Rep. 2018 Oct 30;25(5):1268-1280.e4
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89
J:309702 Men Y, et al., Tprn is essential for the integrity of stereociliary rootlet in cochlear hair cells in mice. Front Med. 2019 Dec;13(6):690-704
J:318211 Salles FT, et al., CLIC5 stabilizes membrane-actin filament linkages at the base of hair cell stereocilia in a molecular complex with radixin, taperin, and myosin VI. Cytoskeleton (Hoboken). 2014 Jan;71(1):61-78
J:345440 Qi J, et al., Critical role of TPRN rings in the stereocilia for hearing. Mol Ther. 2024 Jan 3;32(1):204-217