Sequence Detail

ID/Version

A2AH22 Q8BYW8 Q8BJJ8 Q3U239 Q6ZPJ1 A2AH21 Q3TF60 Q3UF70 A2AH24 (UniProt | EBI)

Last sequence update: 2007-02-20
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=Activating molecule in BECN1-regulated autophagy protein 1 {ECO:0000303|PubMed:17589504};

Provider

SWISS-PROT

Sequence

Polypeptide 1300 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Ambra1	autophagy/beclin 1 regulator 1	99	97	4	93

Sequence references in MGI

J:86686 Okazaki N, et al., Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. DNA Res. 2003 Aug 31;10(4):167-80
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:122795 Maria Fimia G, et al., Ambra1 regulates autophagy and development of the nervous system. Nature. 2007 Jun 28;447(7148):1121-5
J:174518 Van Humbeeck C, et al., Parkin interacts with Ambra1 to induce mitophagy. J Neurosci. 2011 Jul 13;31(28):10249-61
J:202483 Xia P, et al., WASH inhibits autophagy through suppression of Beclin 1 ubiquitination. EMBO J. 2013 Oct 16;32(20):2685-96
J:203423 Pampliega O, et al., Functional interaction between autophagy and ciliogenesis. Nature. 2013 Oct 10;502(7470):194-200
J:251412 Akatsuka H, et al., AMBRA1 is involved in T cell receptor-mediated metabolic reprogramming through an ATG7-independent pathway. Biochem Biophys Res Commun. 2017 Sep 30;491(4):1098-1104
J:258689 Strappazzon F, et al., AMBRA1 is able to induce mitophagy via LC3 binding, regardless of PARKIN and p62/SQSTM1. Cell Death Differ. 2015 Mar;22(3):419-32
J:268220 Cianfanelli V, et al., AMBRA1 links autophagy to cell proliferation and tumorigenesis by promoting c-Myc dephosphorylation and degradation. Nat Cell Biol. 2015 Jan;17(1):20-30
J:305884 Maiani E, et al., AMBRA1 regulates cyclin D to guard S-phase entry and genomic integrity. Nature. 2021 Apr;592(7856):799-803
J:305910 Chaikovsky AC, et al., The AMBRA1 E3 ligase adaptor regulates the stability of cyclin D. Nature. 2021 Apr;592(7856):794-798
J:305916 Simoneschi D, et al., CRL4(AMBRA1) is a master regulator of D-type cyclins. Nature. 2021 Apr;592(7856):789-793
J:306277 Becher J, et al., AMBRA1 Controls Regulatory T-Cell Differentiation and Homeostasis Upstream of the FOXO3-FOXP3 Axis. Dev Cell. 2018 Dec 3;47(5):592-607.e6
J:306378 Guo A, et al., Immunoaffinity enrichment and mass spectrometry analysis of protein methylation. Mol Cell Proteomics. 2014 Jan;13(1):372-87
J:314082 Xia P, et al., RNF2 is recruited by WASH to ubiquitinate AMBRA1 leading to downregulation of autophagy. Cell Res. 2014 Aug;24(8):943-58
J:314089 Schoenherr C, et al., The autophagy protein Ambra1 regulates gene expression by supporting novel transcriptional complexes. J Biol Chem. 2020 Aug 21;295(34):12045-12057