Sequence Detail

ID/Version

A2A935 Q6PB79 Q69ZD6 Q7TPF4 (UniProt | EBI)

Last sequence update: 2008-02-05
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=Histone-lysine N-methyltransferase PRDM16 {ECO:0000305}; EC=2.1.1.367 {ECO:0000269|PubMed:22939622};AltName: Full=PR domain zinc finger protein 16 {ECO:0000305};AltName: Full=PR domain-containing protein 16 {ECO:0000305};AltName: Ful

Provider

SWISS-PROT

Sequence

Polypeptide 1275 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Prdm16	PR domain containing 16	79	129	3	30

Sequence references in MGI

J:86428 Nishikata I, et al., A novel EVI1 gene family, MEL1, lacking a PR domain (MEL1S) is expressed mainly in t(1;3)(p36;q21)-positive AML and blocks G-CSF-induced myeloid differentiation. Blood. 2003 Nov 1;102(9):3323-32
J:92575 Okazaki N, et al., Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. DNA Res. 2004 Jun 30;11(3):205-18
J:122807 Warner DR, et al., PRDM16/MEL1: a novel Smad binding protein expressed in murine embryonic orofacial tissue. Biochim Biophys Acta. 2007 Jun;1773(6):814-20
J:129891 Seale P, et al., Transcriptional control of brown fat determination by PRDM16. Cell Metab. 2007 Jul;6(1):38-54
J:138823 Seale P, et al., PRDM16 controls a brown fat/skeletal muscle switch. Nature. 2008 Aug 21;454(7207):961-7
J:152000 Kajimura S, et al., Initiation of myoblast to brown fat switch by a PRDM16-C/EBP-beta transcriptional complex. Nature. 2009 Aug 27;460(7259):1154-8
J:153416 Kajimura S, et al., Regulation of the brown and white fat gene programs through a PRDM16/CtBP transcriptional complex. Genes Dev. 2008 May 15;22(10):1397-409
J:206694 Arndt AK, et al., Fine mapping of the 1p36 deletion syndrome identifies mutation of PRDM16 as a cause of cardiomyopathy. Am J Hum Genet. 2013 Jul 11;93(1):67-77
J:218161 Dempersmier J, et al., Cold-Inducible Zfp516 Activates UCP1 Transcription to Promote Browning of White Fat and Development of Brown Fat. Mol Cell. 2015 Jan 22;57(2):235-46
J:269562 Pinheiro I, et al., Prdm3 and Prdm16 are H3K9me1 methyltransferases required for mammalian heterochromatin integrity. Cell. 2012 Aug 31;150(5):948-60