Sequence Detail

ID/Version

A2A6C4 Q8BHP0 Q497R4 (UniProt | EBI)

Last sequence update: 2007-02-20
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=Signal peptide peptidase-like 2C {ECO:0000305}; Short=SPP-like 2C {ECO:0000250|UniProtKB:Q8IUH8}; Short=SPPL2c {ECO:0000250|UniProtKB:Q8IUH8}; EC=3.4.23.- {ECO:0000269|PubMed:30733280, ECO:0000269|PubMed:30733281, ECO

Provider

SWISS-PROT

Sequence

Polypeptide 690 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Sppl2c	signal peptide peptidase 2C	47	96	2	9

Sequence references in MGI

J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:272982 Niemeyer J, et al., The intramembrane protease SPPL2c promotes male germ cell development by cleaving phospholamban. EMBO Rep. 2019 Mar;20(3)
J:328498 Contreras W, et al., C11orf94/Frey is a key regulator for male fertility by controlling Izumo1 complex assembly. Sci Adv. 2022 Aug 12;8(32):eabo6049
J:331351 Papadopoulou AA, et al., Signal peptide peptidase-like 2c impairs vesicular transport and cleaves SNARE proteins. EMBO Rep. 2019 Mar;20(3)