Sequence Detail

ID/Version

A2A5Z6 Q5IRE6 A2A5Z7 (UniProt | EBI)

Last sequence update: 2007-02-20
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=E3 ubiquitin-protein ligase SMURF2; EC=2.3.2.26 {ECO:0000250|UniProtKB:Q9HAU4};AltName: Full=HECT-type E3 ubiquitin transferase SMURF2;AltName: Full=SMAD ubiquitination regulatory factor 2;AltName: Full=SMAD-specific E3 ubiquitin-pro

Provider

SWISS-PROT

Sequence

Polypeptide 748 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Smurf2	SMAD specific E3 ubiquitin protein ligase 2	40	99	3	12

Sequence references in MGI

J:97303 Yamashita M, et al., Ubiquitin Ligase Smurf1 Controls Osteoblast Activity and Bone Homeostasis by Targeting MEKK2 for Degradation. Cell. 2005 Apr 8;121(1):101-13
J:108486 Kaneki H, et al., Tumor necrosis factor promotes Runx2 degradation through up-regulation of Smurf1 and Smurf2 in osteoblasts. J Biol Chem. 2006 Feb 17;281(7):4326-33
J:136721 Lee YS, et al., AIMP1/p43 downregulates TGF-beta signaling via stabilization of smurf2. Biochem Biophys Res Commun. 2008 Jul 4;371(3):395-400