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Sequence Detail
ID/Version
A2A5Z6 A2A5Z7 Q5IRE6 (UniProt | EBI) Last sequence update: 2007-02-20
Last annotation update: 2024-03-27
Sequence
description
from provider
RecName: Full=E3 ubiquitin-protein ligase SMURF2; EC=2.3.2.26 {ECO:0000250|UniProtKB:Q9HAU4};AltName: Full=HECT-type E3 ubiquitin transferase SMURF2;AltName: Full=SMAD ubiquitination regulatory factor 2;AltName: Full=SMAD-specific E3 ubiquitin-pro
Provider SWISS-PROT
Sequence
Polypeptide 748 aa
For this sequence
Source
Organism mouse
See UniProt | EBI for source
Annotated genes and markers Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.
Type Symbol Name GO Terms Expression
Assays
Orthologs Phenotypic
Alleles
Gene Smurf2 SMAD specific E3 ubiquitin protein ligase 2 26 99 3 12
Sequence references in MGI J:97303 Yamashita M, et al., Ubiquitin Ligase Smurf1 Controls Osteoblast Activity and Bone Homeostasis by Targeting MEKK2 for Degradation. Cell. 2005 Apr 8;121(1):101-13
J:108486 Kaneki H, et al., Tumor necrosis factor promotes Runx2 degradation through up-regulation of Smurf1 and Smurf2 in osteoblasts. J Biol Chem. 2006 Feb 17;281(7):4326-33
J:136721 Lee YS, et al., AIMP1/p43 downregulates TGF-beta signaling via stabilization of smurf2. Biochem Biophys Res Commun. 2008 Jul 4;371(3):395-400

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
05/07/2024
MGI 6.23
The Jackson Laboratory