Sequence Detail

ID/Version

A2A259 Q80ZH4 Q14B55 Q14B73 (UniProt | EBI)

Last sequence update: 2007-02-20
Last annotation update: 2024-03-27

Sequence description from provider

RecName: Full=Polycystin-2-like protein 1; Short=Polycystin-2L1;AltName: Full=Polycystic kidney disease 2-like 1 protein;AltName: Full=Polycystin-2 homolog;

Provider

SWISS-PROT

Sequence

Polypeptide 760 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Pkd2l1	polycystic kidney disease 2-like 1	65	101	3	14

Sequence references in MGI

J:96951 Murakami M, et al., Genomic organization and functional analysis of murine PKD2L1. J Biol Chem. 2005 Feb 18;280(7):5626-35
J:112032 Huang AL, et al., The cells and logic for mammalian sour taste detection. Nature. 2006 Aug 24;442(7105):934-8
J:153753 Chandrashekar J, et al., The taste of carbonation. Science. 2009 Oct 16;326(5951):443-5
J:164468 Kawaguchi H, et al., Activation of polycystic kidney disease-2-like 1 (PKD2L1)-PKD1L3 complex by acid in mouse taste cells. J Biol Chem. 2010 Jun 4;285(23):17277-81
J:165309 Ishimaru Y, et al., Interaction between PKD1L3 and PKD2L1 through their transmembrane domains is required for localization of PKD2L1 at taste pores in taste cells of circumvallate and foliate papillae. FASEB J. 2010 Oct;24(10):4058-67
J:172581 Horio N, et al., Sour Taste Responses in Mice Lacking PKD Channels. PLoS One. 2011;6(5):e20007
J:182388 Ishimaru Y, et al., Transient receptor potential family members PKD1L3 and PKD2L1 form a candidate sour taste receptor. Proc Natl Acad Sci U S A. 2006 Aug 15;103(33):12569-74
J:198096 Ishii S, et al., The response of PKD1L3/PKD2L1 to acid stimuli is inhibited by capsaicin and its pungent analogs. FEBS J. 2012 May;279(10):1857-70
J:207900 DeCaen PG, et al., Direct recording and molecular identification of the calcium channel of primary cilia. Nature. 2013 Dec 12;504(7479):315-8
J:207901 Delling M, et al., Primary cilia are specialized calcium signalling organelles. Nature. 2013 Dec 12;504(7479):311-4
J:244208 Zocchi D, et al., The cellular mechanism for water detection in the mammalian taste system. Nat Neurosci. 2017 Jul;20(7):927-933
J:257231 Chang RB, et al., A proton current drives action potentials in genetically identified sour taste cells. Proc Natl Acad Sci U S A. 2010 Dec 21;107(51):22320-5
J:266474 Shimizu T, et al., The asparagine 533 residue in the outer pore loop region of the mouse PKD2L1 channel is essential for its voltage-dependent inactivation. FEBS Open Bio. 2017 Sep;7(9):1392-1401
J:283187 Su Q, et al., Cryo-EM structure of the polycystic kidney disease-like channel PKD2L1. Nat Commun. 2018 Mar 22;9(1):1192