Sequence Detail

ID/Version

A1L3P4 Q8BTG0 (UniProt | EBI)

Last sequence update: 2007-02-06
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=Sodium/hydrogen exchanger 6;AltName: Full=Na(+)/H(+) exchanger 6; Short=NHE-6;AltName: Full=Sodium/hydrogen exchanger;AltName: Full=Solute carrier family 9 member 6;

Provider

SWISS-PROT

Sequence

Polypeptide 702 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Slc9a6	solute carrier family 9 (sodium/hydrogen exchanger), member 6	68	99	4	15

Sequence references in MGI

J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:143718 Trost M, et al., The phagosomal proteome in interferon-gamma-activated macrophages. Immunity. 2009 Jan;30(1):143-54
J:193911 Deane EC, et al., Enhanced recruitment of endosomal Na+/H+ exchanger NHE6 into Dendritic spines of hippocampal pyramidal neurons during NMDA receptor-dependent long-term potentiation. J Neurosci. 2013 Jan 9;33(2):595-610
J:201826 Ouyang Q, et al., Christianson Syndrome Protein NHE6 Modulates TrkB Endosomal Signaling Required for Neuronal Circuit Development. Neuron. 2013 Oct 2;80(1):97-112
J:284697 Ouyang Q, et al., Functional Assessment In Vivo of the Mouse Homolog of the Human Ala-9-Ser NHE6 Variant. eNeuro. 2019 Nov/Dec;6(6):ENEURO.0046-19.2019
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89
J:314684 Pescosolido MF, et al., Loss of Christianson Syndrome Na(+)/H(+) Exchanger 6 (NHE6) Causes Abnormal Endosome Maturation and Trafficking Underlying Lysosome Dysfunction in Neurons. J Neurosci. 2021 Nov 3;41(44):9235-9256
J:331349 Hill JK, et al., Vestibular hair bundles control pH with (Na+, K+)/H+ exchangers NHE6 and NHE9. J Neurosci. 2006 Sep 27;26(39):9944-55