Sequence Detail

ID/Version

A1L314 Q61889 A1L315 (UniProt | EBI)

Last sequence update: 2007-02-06
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=Macrophage-expressed gene 1 protein {ECO:0000303|PubMed:23257510}; Short=Macrophage gene 1 protein {ECO:0000303|PubMed:7888681}; Short=Mpg-1 {ECO:0000303|PubMed:7888681};AltName: Full=Perforin-2 {ECO:0000303|PubMed:23257510};

Provider

SWISS-PROT

Sequence

Polypeptide 713 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Mpeg1	macrophage expressed gene 1	32	106	5	12

Sequence references in MGI

J:51737 Spilsbury K, et al., Isolation of a novel macrophage-specific gene by differential cDNA analysis. Blood. 1995 Mar 15;85(6):1620-9
J:267660 Bai F, et al., Perforin-2 Breaches the Envelope of Phagocytosed Bacteria Allowing Antimicrobial Effectors Access to Intracellular Targets. J Immunol. 2018 Nov 1;201(9):2710-2720
J:269438 McCormack RM, et al., Perforin-2 is essential for intracellular defense of parenchymal cells and phagocytes against pathogenic bacteria. Elife. 2015 Sep 24;4:e06508
J:269474 McCormack RM, et al., Enteric pathogens deploy cell cycle inhibiting factors to block the bactericidal activity of Perforin-2. Elife. 2015 Sep 29;4:e06505
J:273539 Fields KA, et al., Perforin-2 restricts growth of Chlamydia trachomatis in macrophages. Infect Immun. 2013 Aug;81(8):3045-54
J:273542 McCormack R, et al., Inhibition of intracellular bacterial replication in fibroblasts is dependent on the perforin-like protein (perforin-2) encoded by macrophage-expressed gene 1. J Innate Immun. 2013;5(2):185-94
J:277965 McCormack R, et al., Perforin-2 Protects Host Cells and Mice by Restricting the Vacuole to Cytosol Transitioning of a Bacterial Pathogen. Infect Immun. 2016 Apr;84(4):1083-1091
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89
J:337206 Rodriguez-Silvestre P, et al., Perforin-2 is a pore-forming effector of endocytic escape in cross-presenting dendritic cells. Science. 2023 Jun 23;380(6651):1258-1265
J:340657 Ni T, et al., Structure and mechanism of bactericidal mammalian perforin-2, an ancient agent of innate immunity. Sci Adv. 2020 Jan;6(5):eaax8286
J:340664 Yu X, et al., Cryo-EM structures of perforin-2 in isolation and assembled on a membrane suggest a mechanism for pore formation. EMBO J. 2022 Dec 1;41(23):e111857
J:341384 Ebrahimnezhaddarzi S, et al., Mpeg1 is not essential for antibacterial or antiviral immunity, but is implicated in antigen presentation. Immunol Cell Biol. 2022 Aug;100(7):529-546