Sequence Detail

ID/Version

Q6RKD8 Q14DT7 Q6RKD9 A0A452J8F8 (UniProt | EBI)

Last sequence update: 2024-01-24
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=Leucine-rich repeat transmembrane protein FLRT1;AltName: Full=Fibronectin leucine rich transmembrane protein 1 {ECO:0000312|EMBL:AAR92201.1};Flags: Precursor;

Provider

SWISS-PROT

Sequence

Polypeptide 674 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Flrt1	fibronectin leucine rich transmembrane protein 1	31	103	4	6

Sequence references in MGI

J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:112631 Haines BP, et al., Regulated expression of FLRT genes implies a functional role in the regulation of FGF signalling during mouse development. Dev Biol. 2006 Sep 1;297(1):14-25
J:136719 Maretto S, et al., Ventral closure, headfold fusion and definitive endoderm migration defects in mouse embryos lacking the fibronectin leucine-rich transmembrane protein FLRT3. Dev Biol. 2008 Jun 1;318(1):184-93
J:196042 Yamagishi S, et al., FLRT2 and FLRT3 act as repulsive guidance cues for Unc5-positive neurons. EMBO J. 2011 Jul 20;30(14):2920-33
J:224730 O'Sullivan ML, et al., FLRT proteins are endogenous latrophilin ligands and regulate excitatory synapse development. Neuron. 2012 Mar 8;73(5):903-10
J:224736 Wheldon LM, et al., Critical role of FLRT1 phosphorylation in the interdependent regulation of FLRT1 function and FGF receptor signalling. PLoS One. 2010;5(4):e10264