MGI 5.13 - Phenotype Browser

Mammalian Phenotype Browser
Term Detail

MP term:	glomerular crescent
MP id:	MP:0011506
Definition:	formation of a crescent-shaped (semi-lunar) glomerular lesion corresponding to extracapillary proliferation of Bowman's capsular epithelium and acquiring a fibroblast-like spindled morphology, possibly stimulated by release of fibrinogen from a ruptured glomerular basement membrane; epithelial crescents occur in aggressive forms of glomerulonephritis, may be accompanied by collagen and fibrin deposition and/or monocyte and macrophage proliferation, may protrude into Bowman's space, and ultimately compress and destroy the glomerular tuft
Number of paths to term:	2

denotes an 'is-a' relationship
denotes a 'part-of' relationship

mammalian phenotype

renal/urinary system phenotype

abnormal renal/urinary system morphology

abnormal kidney morphology

abnormal kidney cortex morphology

abnormal renal corpuscle morphology

abnormal renal glomerulus morphology

abnormal glomerular capillary morphology +

abnormal glomerular filtration barrier morphology

abnormal glomerular mesangium morphology +

absent renal glomerulus

cortical renal glomerulopathies +

decreased renal glomerulus number

glomerular crescent [MP:0011506] (23 genotypes, 23 annotations)

increased renal glomerulus lobularity

renal glomerular synechia

renal glomerulus atrophy

renal glomerulus fibrosis

renal glomerulus hypertrophy