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Mammalian Phenotype Browser
Term Detail
MP term:abnormal tricarboxylic acid cycle
Synonym: abnormal citric acid cycle
Synonym: abnormal Krebs cycle
Synonym: abnormal TCA cycle
MP id: MP:0010958
Definition: any anomaly in the universal metabolic pathway in which the acetyl group of acetyl coenzyme A is effectively oxidized to two CO2 and four pairs of electrons are transferred to coenzymes; the acetyl group combines with oxaloacetate to form citrate, which undergoes successive transformations to isocitrate, 2-oxoglutarate, succinyl-CoA, succinate, fumarate, malate, and oxaloacetate again, thus completing the cycle
Number of paths to term: 2

is-adenotes an 'is-a' relationship
part-ofdenotes a 'part-of' relationship


mammalian phenotype
        is-acellular phenotype
                is-aabnormal cell physiology
                        is-aabnormal cellular respiration
                                is-aabnormal aerobic respiration
                                        is-aabnormal tricarboxylic acid cycle [MP:0010958] (11 genotypes, 11 annotations)


mammalian phenotype
        is-acellular phenotype
                is-aabnormal cell physiology
                        is-aabnormal mitochondrial physiology
                                is-aabnormal mitochondrial proliferation +
                                is-aabnormal oxidative phosphorylation +
                                is-aabnormal respiratory electron transport chain +
                                is-aabnormal tricarboxylic acid cycle [MP:0010958] (11 genotypes, 11 annotations)

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last database update
12/09/2014
MGI 5.20
The Jackson Laboratory