| MP term: | abnormal tricarboxylic acid cycle |
| Synonym: | abnormal citric acid cycle |
| Synonym: | abnormal Krebs cycle |
| Synonym: | abnormal TCA cycle |
| MP id: | MP:0010958 |
| Definition: | any anomaly in the universal metabolic pathway in which the acetyl group of acetyl coenzyme A is effectively oxidized to two CO2 and four pairs of electrons are transferred to coenzymes; the acetyl group combines with oxaloacetate to form citrate, which undergoes successive transformations to isocitrate, 2-oxoglutarate, succinyl-CoA, succinate, fumarate, malate, and oxaloacetate again, thus completing the cycle |
| Number of paths to term: | 2 |
denotes an 'is-a' relationship
denotes a 'part-of' relationship
cellular phenotypeabnormal cell physiologyabnormal cellular respirationabnormal aerobic respirationabnormal tricarboxylic acid cycle [MP:0010958] (10 genotypes, 10 annotations)cellular phenotypeabnormal cell physiologyabnormal mitochondrial physiologyabnormal mitochondrial proliferation +abnormal oxidative phosphorylation +abnormal respiratory electron transport chain +abnormal tricarboxylic acid cycle [MP:0010958] (10 genotypes, 10 annotations)Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc |
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last database update 05/08/2013 MGI 5.13 |
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