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Mammalian Phenotype Browser
Term Detail
MP term:abnormal NK cell physiology
Synonym: abnormal natural killer cell physiology
Synonym: dysfunctional NK cells
Synonym: natural killer cell dysfunction
Synonym: NK cell dysfunction
MP id: MP:0010766
Alternate id: MP:0005069
Definition: any functional anomaly of a lymphocyte that can spontaneously kill a variety of target cells without prior antigenic activation via germline encoded activation receptors, and also regulate immune responses via cytokine release and direct contact with other cells
Number of paths to term: 5

is-adenotes an 'is-a' relationship
part-ofdenotes a 'part-of' relationship


mammalian phenotype
        is-ahematopoietic system phenotype
                is-aabnormal hematopoietic system physiology
                        is-aabnormal blood cell physiology
                                is-aabnormal leukocyte physiology
                                        is-aabnormal lymphocyte physiology
                                                is-aabnormal B cell physiology +
                                                is-aabnormal NK cell physiology [MP:0010766] (182 genotypes, 207 annotations)
                                                        is-aabnormal natural killer cell mediated cytotoxicity +
                                                        is-aabnormal uterine NK cell physiology
                                                is-aabnormal T cell physiology +


mammalian phenotype
        is-aimmune system phenotype
                is-aabnormal immune system physiology
                        is-aabnormal adaptive immunity
                                is-aabnormal leukocyte physiology
                                        is-aabnormal lymphocyte physiology
                                                is-aabnormal B cell physiology +
                                                is-aabnormal NK cell physiology [MP:0010766] (182 genotypes, 207 annotations)
                                                        is-aabnormal natural killer cell mediated cytotoxicity +
                                                        is-aabnormal uterine NK cell physiology
                                                is-aabnormal T cell physiology +


mammalian phenotype
        is-aimmune system phenotype
                is-aabnormal immune system physiology
                        is-aabnormal cell-mediated immunity
                                is-aabnormal leukocyte physiology
                                        is-aabnormal lymphocyte physiology
                                                is-aabnormal B cell physiology +
                                                is-aabnormal NK cell physiology [MP:0010766] (182 genotypes, 207 annotations)
                                                        is-aabnormal natural killer cell mediated cytotoxicity +
                                                        is-aabnormal uterine NK cell physiology
                                                is-aabnormal T cell physiology +


mammalian phenotype
        is-aimmune system phenotype
                is-aabnormal immune system physiology
                        is-aabnormal immune cell physiology
                                is-aabnormal leukocyte physiology
                                        is-aabnormal lymphocyte physiology
                                                is-aabnormal B cell physiology +
                                                is-aabnormal NK cell physiology [MP:0010766] (182 genotypes, 207 annotations)
                                                        is-aabnormal natural killer cell mediated cytotoxicity +
                                                        is-aabnormal uterine NK cell physiology
                                                is-aabnormal T cell physiology +


mammalian phenotype
        is-aimmune system phenotype
                is-aabnormal immune system physiology
                        is-aabnormal innate immunity
                                is-aabnormal acute phase protein level +
                                is-aabnormal complement pathway +
                                is-aabnormal macrophage physiology +
                                is-aabnormal neutrophil physiology +
                                is-aabnormal NK cell physiology [MP:0010766] (182 genotypes, 207 annotations)
                                        is-aabnormal natural killer cell mediated cytotoxicity +
                                        is-aabnormal uterine NK cell physiology

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last database update
04/08/2014
MGI 5.17
The Jackson Laboratory