| MP term: | abnormal NK cell physiology |
| Synonym: | abnormal natural killer cell physiology |
| Synonym: | dysfunctional NK cells |
| Synonym: | natural killer cell dysfunction |
| Synonym: | NK cell dysfunction |
| MP id: | MP:0010766 |
| Alternate id: | MP:0005069 |
| Definition: | any functional anomaly of a lymphocyte that can spontaneously kill a variety of target cells without prior antigenic activation via germline encoded activation receptors, and also regulate immune responses via cytokine release and direct contact with other cells |
| Number of paths to term: | 4 |
denotes an 'is-a' relationship
denotes a 'part-of' relationship
immune system phenotypeabnormal immune system physiologyabnormal adaptive immunityabnormal leukocyte physiologyabnormal lymphocyte physiologyabnormal B cell physiology +abnormal B lymphocyte antigen presentation +abnormal NK cell physiology [MP:0010766] (177 genotypes, 198 annotations)abnormal natural killer cell mediated cytotoxicity +abnormal uterine NK cell physiologyabnormal T cell physiology +immune system phenotypeabnormal immune system physiologyabnormal cell-mediated immunityabnormal leukocyte physiologyabnormal lymphocyte physiologyabnormal B cell physiology +abnormal B lymphocyte antigen presentation +abnormal NK cell physiology [MP:0010766] (177 genotypes, 198 annotations)abnormal natural killer cell mediated cytotoxicity +abnormal uterine NK cell physiologyabnormal T cell physiology +immune system phenotypeabnormal immune system physiologyabnormal immune cell physiologyabnormal leukocyte physiologyabnormal lymphocyte physiologyabnormal B cell physiology +abnormal B lymphocyte antigen presentation +abnormal NK cell physiology [MP:0010766] (177 genotypes, 198 annotations)abnormal natural killer cell mediated cytotoxicity +abnormal uterine NK cell physiologyabnormal T cell physiology +immune system phenotypeabnormal immune system physiologyabnormal innate immunityabnormal acute phase protein level +abnormal complement pathway +abnormal macrophage physiology +abnormal neutrophil physiology +abnormal NK cell physiology [MP:0010766] (177 genotypes, 198 annotations)abnormal natural killer cell mediated cytotoxicity +abnormal uterine NK cell physiologyMouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc |
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last database update 05/22/2013 MGI 5.13 |
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