| MP term: | increased number of Howell-Jolly bodies |
| Synonym: | increased number of nuclear fragments in erythrocytes |
| MP id: | MP:0010178 |
| Definition: | abnormal presence of basophilic nuclear remnants of condensed DNA (1 to 2 um in diameter) in circulating erythrocytes, typically seen in severe hemolytic anemias or after splenectomy; these inclusions are normally removed by the spleen but will persist in individuals with functional hyposplenia or asplenia |
| Number of paths to term: | 1 |
denotes an 'is-a' relationship
denotes a 'part-of' relationship
hematopoietic system phenotypeabnormal hematopoietic system morphology/developmentabnormal blood cell morphology/developmentabnormal hematopoiesisabnormal erythropoiesisabnormal erythrocyte morphologyabnormal erythrocyte cell number +abnormal fetal derived definitive erythrocyte morphology +abnormal hematocrit +abnormal hemoglobin +abnormal hemoglobin concentration distribution width +abnormal mean corpuscular volume +abnormal red blood cell deformabilityabnormal red blood cell distribution width +acanthocytosisanemia +anisopoikilocytosisdacryocytosisechinocytosiselliptocytosishyperchromasiaincreased erythrocyte protoporphyrin levelincreased nucleated erythrocyte cell numberincreased number of Heinz bodiesincreased number of Howell-Jolly bodies [MP:0010178] (11 genotypes, 11 annotations)increased siderocyte numberleptocytosismacrocytosismicrocytosispoikilocytosis +polychromatophiliaspherocytosisstomatocytosisMouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc |
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last database update 06/05/2013 MGI 5.13 |
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