| MP term: | leptocytosis |
| Synonym: | increased codocyte number |
| Synonym: | increased Mexican hat cell number |
| Synonym: | increased target cell number |
| Synonym: | Mexican hat erythrocytes |
| Synonym: | target erythrocytes |
| Synonym: | wafer-thin erythrocytes |
| MP id: | MP:0010175 |
| Definition: | the presence of unusually thin or flattened red blood cells that when stained show a dark center and a peripheral ring of hemoglobin, separated by a pale unstained ring containing less hemoglobin, resulting in a bull's-eye appearance and resembling a 3D sombrero when viewed under EM; seen in certain anemias, thalassemias, hemoglobinopathies, obstructive jaundice, and the post-splenectomy state |
| Number of paths to term: | 1 |
denotes an 'is-a' relationship
denotes a 'part-of' relationship
hematopoietic system phenotypeabnormal hematopoietic system morphology/developmentabnormal blood cell morphology/developmentabnormal hematopoiesisabnormal erythropoiesisabnormal erythrocyte morphologyabnormal erythrocyte cell number +abnormal fetal derived definitive erythrocyte morphology +abnormal hematocrit +abnormal hemoglobin +abnormal hemoglobin concentration distribution width +abnormal mean corpuscular volume +abnormal red blood cell deformabilityabnormal red blood cell distribution width +acanthocytosisanemia +anisopoikilocytosisdacryocytosisechinocytosiselliptocytosishyperchromasiaincreased erythrocyte protoporphyrin levelincreased nucleated erythrocyte cell numberincreased number of Heinz bodiesincreased number of Howell-Jolly bodiesincreased siderocyte numberleptocytosis [MP:0010175] (13 genotypes, 13 annotations)macrocytosismicrocytosispoikilocytosis +polychromatophiliaspherocytosisstomatocytosisMouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc |
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last database update 06/05/2013 MGI 5.13 |
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