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Mammalian Phenotype Browser
Term Detail
MP term:leptocytosis
Synonym: increased codocyte number
Synonym: increased Mexican hat cell number
Synonym: increased target cell number
Synonym: Mexican hat erythrocytes
Synonym: target erythrocytes
Synonym: wafer-thin erythrocytes
MP id: MP:0010175
Definition: the presence of unusually thin or flattened red blood cells that when stained show a dark center and a peripheral ring of hemoglobin, separated by a pale unstained ring containing less hemoglobin, resulting in a bull's-eye appearance and resembling a 3D sombrero when viewed under EM; seen in certain anemias, thalassemias, hemoglobinopathies, obstructive jaundice, and the post-splenectomy state
Number of paths to term: 1

is-adenotes an 'is-a' relationship
part-ofdenotes a 'part-of' relationship


mammalian phenotype
        is-ahematopoietic system phenotype
                is-aabnormal hematopoietic system morphology/development
                        is-aabnormal blood cell morphology/development
                                is-aabnormal hematopoiesis
                                        is-aabnormal erythropoiesis
                                                is-aabnormal erythrocyte morphology
                                                        is-aabnormal erythrocyte cell number +
                                                        is-aabnormal erythrocyte ion content +
                                                        is-aabnormal erythrocyte magnesium level +
                                                        is-aabnormal erythrocyte potassium level +
                                                        is-aabnormal erythrocyte sodium level +
                                                        is-aabnormal fetal derived definitive erythrocyte morphology +
                                                        is-aabnormal hematocrit +
                                                        is-aabnormal hemoglobin +
                                                        is-aabnormal mean corpuscular volume +
                                                        is-aabnormal nucleated erythrocyte cell number +
                                                        is-aabnormal red blood cell deformability
                                                        is-aabnormal red blood cell distribution width +
                                                        is-aacanthocytosis
                                                        is-aanisopoikilocytosis
                                                        is-adacryocytosis
                                                        is-aechinocytosis
                                                        is-aelliptocytosis
                                                        is-ahyperchromasia
                                                        is-aincreased erythrocyte protoporphyrin level
                                                        is-aincreased number of Heinz bodies
                                                        is-aincreased number of Howell-Jolly bodies
                                                        is-aincreased siderocyte number
                                                        is-aleptocytosis [MP:0010175] (13 genotypes, 13 annotations)
                                                        is-amacrocytosis
                                                        is-amicrocytosis
                                                        is-apoikilocytosis +
                                                        is-apolychromatophilia
                                                        is-aspherocytosis
                                                        is-astomatocytosis

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last database update
10/08/2014
MGI 5.20
The Jackson Laboratory