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Mammalian Phenotype Browser
Term Detail
MP term:decreased tumor necrosis factor secretion
Synonym: decreased cachectin secretion
Synonym: decreased TNFA secretion
Synonym: decreased TNF secretion
Synonym: decreased tumor necrosis factor alpha secretion
Synonym: reduced cachectin secretion
Synonym: reduced TNFA secretion
Synonym: reduced TNF secretion
Synonym: reduced tumor necrosis factor alpha secretion
MP id: MP:0008561
Definition: reduction in the production or release of a serum glycoprotein produced by activated macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium
Number of paths to term: 1

is-adenotes an 'is-a' relationship
part-ofdenotes a 'part-of' relationship

mammalian phenotype
        is-aimmune system phenotype
                is-aabnormal immune system physiology
                        is-aabnormal immune serum protein physiology
                                is-aabnormal cytokine secretion
                                        is-aabnormal tumor necrosis factor secretion
                                                is-adecreased tumor necrosis factor secretion [MP:0008561] (204 genotypes, 204 annotations)
                                                is-aincreased tumor necrosis factor secretion

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.08
The Jackson Laboratory