| MP term: | increased tumor necrosis factor secretion |
| Synonym: | increased cachectin secretion |
| Synonym: | increased TNFA secretion |
| Synonym: | increased TNF secretion |
| Synonym: | increased tumor necrosis factor alpha secretion |
| MP id: | MP:0008560 |
| Definition: | increase in the production or release of a serum glycoprotein produced by activated macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium |
| Number of paths to term: | 1 |
denotes an 'is-a' relationship
denotes a 'part-of' relationship
immune system phenotypeabnormal immune system physiologyabnormal immune serum protein physiologyabnormal cytokine secretionabnormal tumor necrosis factor secretiondecreased tumor necrosis factor secretionincreased tumor necrosis factor secretion [MP:0008560] (120 genotypes, 120 annotations)Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc |
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last database update 05/08/2013 MGI 5.13 |
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