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Mammalian Phenotype Browser
Term Detail
MP term:increased tumor necrosis factor secretion
Synonym: increased cachectin secretion
Synonym: increased TNFA secretion
Synonym: increased TNF secretion
Synonym: increased tumor necrosis factor alpha secretion
MP id: MP:0008560
Definition: increase in the production or release of a serum glycoprotein produced by activated macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium
Number of paths to term: 1

is-adenotes an 'is-a' relationship
part-ofdenotes a 'part-of' relationship

mammalian phenotype
        is-aimmune system phenotype
                is-aabnormal immune system physiology
                        is-aabnormal immune serum protein physiology
                                is-aabnormal cytokine secretion
                                        is-aabnormal tumor necrosis factor secretion
                                                is-adecreased tumor necrosis factor secretion
                                                is-aincreased tumor necrosis factor secretion [MP:0008560] (145 genotypes, 145 annotations)

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Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.08
The Jackson Laboratory