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Mammalian Phenotype Browser
Term Detail
MP term:abnormal B cell activation
MP id: MP:0008217
Definition: any anomaly in the normal change in morphology and behavior of a mature or immature B cell during an immune response, resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific
Number of paths to term: 13

is-adenotes an 'is-a' relationship
part-ofdenotes a 'part-of' relationship


mammalian phenotype
        is-ahematopoietic system phenotype
                is-aabnormal hematopoietic system morphology/development
                        is-aabnormal blood cell morphology/development
                                is-aabnormal hematopoiesis
                                        is-aabnormal leukocyte morphology
                                                is-aabnormal mononuclear cell morphology
                                                        is-aabnormal lymphocyte morphology
                                                                is-aabnormal B cell morphology
                                                                        is-aabnormal B cell differentiation
                                                                                is-aabnormal B cell activation [MP:0008217] (318 genotypes, 356 annotations)
                                                                                        is-aabnormal B cell proliferation +
                                                                                is-aabnormal B cell receptor editing
                                                                                is-aabnormal B cell selection +
                                                                                is-aabnormal class switch recombination
                                                                                is-aabnormal immature B cell morphology +
                                                                                is-aabnormal immunoglobulin V(D)J recombination +
                                                                                is-aabnormal memory B cell differentiation
                                                                                is-aabnormal plasma cell differentiation
                                                                                is-aabnormal pro-B cell morphology +
                                                                                is-aabnormal somatic hypermutation frequency
                                                                                is-aarrested B cell differentiation


mammalian phenotype
        is-ahematopoietic system phenotype
                is-aabnormal hematopoietic system morphology/development
                        is-aabnormal blood cell morphology/development
                                is-aabnormal hematopoiesis
                                        is-aabnormal leukocyte morphology
                                                is-aabnormal mononuclear cell morphology
                                                        is-aabnormal lymphocyte morphology
                                                                is-aabnormal lymphopoiesis
                                                                        is-aabnormal B cell differentiation
                                                                                is-aabnormal B cell activation [MP:0008217] (318 genotypes, 356 annotations)
                                                                                        is-aabnormal B cell proliferation +
                                                                                is-aabnormal B cell receptor editing
                                                                                is-aabnormal B cell selection +
                                                                                is-aabnormal class switch recombination
                                                                                is-aabnormal immature B cell morphology +
                                                                                is-aabnormal immunoglobulin V(D)J recombination +
                                                                                is-aabnormal memory B cell differentiation
                                                                                is-aabnormal plasma cell differentiation
                                                                                is-aabnormal pro-B cell morphology +
                                                                                is-aabnormal somatic hypermutation frequency
                                                                                is-aarrested B cell differentiation


mammalian phenotype
        is-ahematopoietic system phenotype
                is-aabnormal hematopoietic system morphology/development
                        is-aabnormal blood cell morphology/development
                                is-aabnormal hematopoiesis
                                        is-aabnormal leukopoiesis
                                                is-aabnormal lymphopoiesis
                                                        is-aabnormal B cell differentiation
                                                                is-aabnormal B cell activation [MP:0008217] (318 genotypes, 356 annotations)
                                                                        is-aabnormal B cell proliferation +
                                                                is-aabnormal B cell receptor editing
                                                                is-aabnormal B cell selection +
                                                                is-aabnormal class switch recombination
                                                                is-aabnormal immature B cell morphology +
                                                                is-aabnormal immunoglobulin V(D)J recombination +
                                                                is-aabnormal memory B cell differentiation
                                                                is-aabnormal plasma cell differentiation
                                                                is-aabnormal pro-B cell morphology +
                                                                is-aabnormal somatic hypermutation frequency
                                                                is-aarrested B cell differentiation


mammalian phenotype
        is-ahematopoietic system phenotype
                is-aabnormal hematopoietic system physiology
                        is-aabnormal blood cell physiology
                                is-aabnormal leukocyte physiology
                                        is-aabnormal lymphocyte physiology
                                                is-aabnormal B cell physiology
                                                        is-aabnormal B cell activation [MP:0008217] (318 genotypes, 356 annotations)
                                                                is-aabnormal B cell proliferation +
                                                        is-aabnormal B cell apoptosis +
                                                        is-aabnormal B lymphocyte antigen presentation +
                                                        is-aabnormal class switch recombination
                                                        is-aabnormal follicular B cell physiology
                                                        is-aabnormal germinal center B cell physiology
                                                        is-aabnormal immunoglobulin level +
                                                        is-aabnormal marginal zone B cell physiology
                                                        is-aabnormal memory B cell physiology


mammalian phenotype
        is-aimmune system phenotype
                is-aabnormal immune system morphology
                        is-aabnormal immune system cell morphology
                                is-aabnormal leukocyte morphology
                                        is-aabnormal mononuclear cell morphology
                                                is-aabnormal lymphocyte morphology
                                                        is-aabnormal B cell morphology
                                                                is-aabnormal B cell differentiation
                                                                        is-aabnormal B cell activation [MP:0008217] (318 genotypes, 356 annotations)
                                                                                is-aabnormal B cell proliferation +
                                                                        is-aabnormal B cell receptor editing
                                                                        is-aabnormal B cell selection +
                                                                        is-aabnormal class switch recombination
                                                                        is-aabnormal immature B cell morphology +
                                                                        is-aabnormal immunoglobulin V(D)J recombination +
                                                                        is-aabnormal memory B cell differentiation
                                                                        is-aabnormal plasma cell differentiation
                                                                        is-aabnormal pro-B cell morphology +
                                                                        is-aabnormal somatic hypermutation frequency
                                                                        is-aarrested B cell differentiation


mammalian phenotype
        is-aimmune system phenotype
                is-aabnormal immune system morphology
                        is-aabnormal immune system cell morphology
                                is-aabnormal leukocyte morphology
                                        is-aabnormal mononuclear cell morphology
                                                is-aabnormal lymphocyte morphology
                                                        is-aabnormal lymphopoiesis
                                                                is-aabnormal B cell differentiation
                                                                        is-aabnormal B cell activation [MP:0008217] (318 genotypes, 356 annotations)
                                                                                is-aabnormal B cell proliferation +
                                                                        is-aabnormal B cell receptor editing
                                                                        is-aabnormal B cell selection +
                                                                        is-aabnormal class switch recombination
                                                                        is-aabnormal immature B cell morphology +
                                                                        is-aabnormal immunoglobulin V(D)J recombination +
                                                                        is-aabnormal memory B cell differentiation
                                                                        is-aabnormal plasma cell differentiation
                                                                        is-aabnormal pro-B cell morphology +
                                                                        is-aabnormal somatic hypermutation frequency
                                                                        is-aarrested B cell differentiation


mammalian phenotype
        is-aimmune system phenotype
                is-aabnormal immune system morphology
                        is-aabnormal immune system cell morphology
                                is-aabnormal leukopoiesis
                                        is-aabnormal lymphopoiesis
                                                is-aabnormal B cell differentiation
                                                        is-aabnormal B cell activation [MP:0008217] (318 genotypes, 356 annotations)
                                                                is-aabnormal B cell proliferation +
                                                        is-aabnormal B cell receptor editing
                                                        is-aabnormal B cell selection +
                                                        is-aabnormal class switch recombination
                                                        is-aabnormal immature B cell morphology +
                                                        is-aabnormal immunoglobulin V(D)J recombination +
                                                        is-aabnormal memory B cell differentiation
                                                        is-aabnormal plasma cell differentiation
                                                        is-aabnormal pro-B cell morphology +
                                                        is-aabnormal somatic hypermutation frequency
                                                        is-aarrested B cell differentiation


mammalian phenotype
        is-aimmune system phenotype
                is-aabnormal immune system physiology
                        is-aabnormal adaptive immunity
                                is-aabnormal leukocyte physiology
                                        is-aabnormal lymphocyte physiology
                                                is-aabnormal B cell physiology
                                                        is-aabnormal B cell activation [MP:0008217] (318 genotypes, 356 annotations)
                                                                is-aabnormal B cell proliferation +
                                                        is-aabnormal B cell apoptosis +
                                                        is-aabnormal B lymphocyte antigen presentation +
                                                        is-aabnormal class switch recombination
                                                        is-aabnormal follicular B cell physiology
                                                        is-aabnormal germinal center B cell physiology
                                                        is-aabnormal immunoglobulin level +
                                                        is-aabnormal marginal zone B cell physiology
                                                        is-aabnormal memory B cell physiology


mammalian phenotype
        is-aimmune system phenotype
                is-aabnormal immune system physiology
                        is-aabnormal adaptive immunity
                                is-aabnormal professional antigen presenting cell physiology
                                        is-aabnormal B cell physiology
                                                is-aabnormal B cell activation [MP:0008217] (318 genotypes, 356 annotations)
                                                        is-aabnormal B cell proliferation +
                                                is-aabnormal B cell apoptosis +
                                                is-aabnormal B lymphocyte antigen presentation +
                                                is-aabnormal class switch recombination
                                                is-aabnormal follicular B cell physiology
                                                is-aabnormal germinal center B cell physiology
                                                is-aabnormal immunoglobulin level +
                                                is-aabnormal marginal zone B cell physiology
                                                is-aabnormal memory B cell physiology


mammalian phenotype
        is-aimmune system phenotype
                is-aabnormal immune system physiology
                        is-aabnormal cell-mediated immunity
                                is-aabnormal leukocyte physiology
                                        is-aabnormal lymphocyte physiology
                                                is-aabnormal B cell physiology
                                                        is-aabnormal B cell activation [MP:0008217] (318 genotypes, 356 annotations)
                                                                is-aabnormal B cell proliferation +
                                                        is-aabnormal B cell apoptosis +
                                                        is-aabnormal B lymphocyte antigen presentation +
                                                        is-aabnormal class switch recombination
                                                        is-aabnormal follicular B cell physiology
                                                        is-aabnormal germinal center B cell physiology
                                                        is-aabnormal immunoglobulin level +
                                                        is-aabnormal marginal zone B cell physiology
                                                        is-aabnormal memory B cell physiology


mammalian phenotype
        is-aimmune system phenotype
                is-aabnormal immune system physiology
                        is-aabnormal cell-mediated immunity
                                is-aabnormal professional antigen presenting cell physiology
                                        is-aabnormal B cell physiology
                                                is-aabnormal B cell activation [MP:0008217] (318 genotypes, 356 annotations)
                                                        is-aabnormal B cell proliferation +
                                                is-aabnormal B cell apoptosis +
                                                is-aabnormal B lymphocyte antigen presentation +
                                                is-aabnormal class switch recombination
                                                is-aabnormal follicular B cell physiology
                                                is-aabnormal germinal center B cell physiology
                                                is-aabnormal immunoglobulin level +
                                                is-aabnormal marginal zone B cell physiology
                                                is-aabnormal memory B cell physiology


mammalian phenotype
        is-aimmune system phenotype
                is-aabnormal immune system physiology
                        is-aabnormal immune cell physiology
                                is-aabnormal leukocyte physiology
                                        is-aabnormal lymphocyte physiology
                                                is-aabnormal B cell physiology
                                                        is-aabnormal B cell activation [MP:0008217] (318 genotypes, 356 annotations)
                                                                is-aabnormal B cell proliferation +
                                                        is-aabnormal B cell apoptosis +
                                                        is-aabnormal B lymphocyte antigen presentation +
                                                        is-aabnormal class switch recombination
                                                        is-aabnormal follicular B cell physiology
                                                        is-aabnormal germinal center B cell physiology
                                                        is-aabnormal immunoglobulin level +
                                                        is-aabnormal marginal zone B cell physiology
                                                        is-aabnormal memory B cell physiology


mammalian phenotype
        is-aimmune system phenotype
                is-aabnormal immune system physiology
                        is-aabnormal immune cell physiology
                                is-aabnormal professional antigen presenting cell physiology
                                        is-aabnormal B cell physiology
                                                is-aabnormal B cell activation [MP:0008217] (318 genotypes, 356 annotations)
                                                        is-aabnormal B cell proliferation +
                                                is-aabnormal B cell apoptosis +
                                                is-aabnormal B lymphocyte antigen presentation +
                                                is-aabnormal class switch recombination
                                                is-aabnormal follicular B cell physiology
                                                is-aabnormal germinal center B cell physiology
                                                is-aabnormal immunoglobulin level +
                                                is-aabnormal marginal zone B cell physiology
                                                is-aabnormal memory B cell physiology

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last database update
11/18/2014
MGI 5.20
The Jackson Laboratory