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Mammalian Phenotype Browser
Term Detail
MP term:abnormal germinal center B cell physiology
MP id: MP:0008192
Definition: abnormal function of a rapidly cycling mature B cell which have downregulated IgD expression and exhibit high levels of binding by peanut agglutinin (PNA), and are involved in T-dependent immune responses; germinal center B cells are found typically in the germinal centers of lymph nodes
Number of paths to term: 7

is-adenotes an 'is-a' relationship
part-ofdenotes a 'part-of' relationship


mammalian phenotype
        is-ahematopoietic system phenotype
                is-aabnormal hematopoietic system physiology
                        is-aabnormal blood cell physiology
                                is-aabnormal leukocyte physiology
                                        is-aabnormal lymphocyte physiology
                                                is-aabnormal B cell physiology
                                                        is-aabnormal B cell activation +
                                                        is-aabnormal B cell apoptosis +
                                                        is-aabnormal B lymphocyte antigen presentation +
                                                        is-aabnormal class switch recombination
                                                        is-aabnormal follicular B cell physiology
                                                        is-aabnormal germinal center B cell physiology [MP:0008192] (19 genotypes, 19 annotations)
                                                        is-aabnormal immunoglobulin level +
                                                        is-aabnormal marginal zone B cell physiology
                                                        is-aabnormal memory B cell physiology


mammalian phenotype
        is-aimmune system phenotype
                is-aabnormal immune system physiology
                        is-aabnormal adaptive immunity
                                is-aabnormal leukocyte physiology
                                        is-aabnormal lymphocyte physiology
                                                is-aabnormal B cell physiology
                                                        is-aabnormal B cell activation +
                                                        is-aabnormal B cell apoptosis +
                                                        is-aabnormal B lymphocyte antigen presentation +
                                                        is-aabnormal class switch recombination
                                                        is-aabnormal follicular B cell physiology
                                                        is-aabnormal germinal center B cell physiology [MP:0008192] (19 genotypes, 19 annotations)
                                                        is-aabnormal immunoglobulin level +
                                                        is-aabnormal marginal zone B cell physiology
                                                        is-aabnormal memory B cell physiology


mammalian phenotype
        is-aimmune system phenotype
                is-aabnormal immune system physiology
                        is-aabnormal adaptive immunity
                                is-aabnormal professional antigen presenting cell physiology
                                        is-aabnormal B cell physiology
                                                is-aabnormal B cell activation +
                                                is-aabnormal B cell apoptosis +
                                                is-aabnormal B lymphocyte antigen presentation +
                                                is-aabnormal class switch recombination
                                                is-aabnormal follicular B cell physiology
                                                is-aabnormal germinal center B cell physiology [MP:0008192] (19 genotypes, 19 annotations)
                                                is-aabnormal immunoglobulin level +
                                                is-aabnormal marginal zone B cell physiology
                                                is-aabnormal memory B cell physiology


mammalian phenotype
        is-aimmune system phenotype
                is-aabnormal immune system physiology
                        is-aabnormal cell-mediated immunity
                                is-aabnormal leukocyte physiology
                                        is-aabnormal lymphocyte physiology
                                                is-aabnormal B cell physiology
                                                        is-aabnormal B cell activation +
                                                        is-aabnormal B cell apoptosis +
                                                        is-aabnormal B lymphocyte antigen presentation +
                                                        is-aabnormal class switch recombination
                                                        is-aabnormal follicular B cell physiology
                                                        is-aabnormal germinal center B cell physiology [MP:0008192] (19 genotypes, 19 annotations)
                                                        is-aabnormal immunoglobulin level +
                                                        is-aabnormal marginal zone B cell physiology
                                                        is-aabnormal memory B cell physiology


mammalian phenotype
        is-aimmune system phenotype
                is-aabnormal immune system physiology
                        is-aabnormal cell-mediated immunity
                                is-aabnormal professional antigen presenting cell physiology
                                        is-aabnormal B cell physiology
                                                is-aabnormal B cell activation +
                                                is-aabnormal B cell apoptosis +
                                                is-aabnormal B lymphocyte antigen presentation +
                                                is-aabnormal class switch recombination
                                                is-aabnormal follicular B cell physiology
                                                is-aabnormal germinal center B cell physiology [MP:0008192] (19 genotypes, 19 annotations)
                                                is-aabnormal immunoglobulin level +
                                                is-aabnormal marginal zone B cell physiology
                                                is-aabnormal memory B cell physiology


mammalian phenotype
        is-aimmune system phenotype
                is-aabnormal immune system physiology
                        is-aabnormal immune cell physiology
                                is-aabnormal leukocyte physiology
                                        is-aabnormal lymphocyte physiology
                                                is-aabnormal B cell physiology
                                                        is-aabnormal B cell activation +
                                                        is-aabnormal B cell apoptosis +
                                                        is-aabnormal B lymphocyte antigen presentation +
                                                        is-aabnormal class switch recombination
                                                        is-aabnormal follicular B cell physiology
                                                        is-aabnormal germinal center B cell physiology [MP:0008192] (19 genotypes, 19 annotations)
                                                        is-aabnormal immunoglobulin level +
                                                        is-aabnormal marginal zone B cell physiology
                                                        is-aabnormal memory B cell physiology


mammalian phenotype
        is-aimmune system phenotype
                is-aabnormal immune system physiology
                        is-aabnormal immune cell physiology
                                is-aabnormal professional antigen presenting cell physiology
                                        is-aabnormal B cell physiology
                                                is-aabnormal B cell activation +
                                                is-aabnormal B cell apoptosis +
                                                is-aabnormal B lymphocyte antigen presentation +
                                                is-aabnormal class switch recombination
                                                is-aabnormal follicular B cell physiology
                                                is-aabnormal germinal center B cell physiology [MP:0008192] (19 genotypes, 19 annotations)
                                                is-aabnormal immunoglobulin level +
                                                is-aabnormal marginal zone B cell physiology
                                                is-aabnormal memory B cell physiology

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last database update
04/08/2014
MGI 5.17
The Jackson Laboratory