MGI 5.13 - Phenotype Browser

Mammalian Phenotype Browser
Term Detail

MP term:	absent Langerhans cell
MP id:	MP:0008118
Definition:	absence of stellate dendritic cells of myeloid origin, that appear clear on light microscopy and has a dark-staining, indented nucleus and characteristic inclusions (Birbeck granules) in the cytoplasm; Langerhans cells are found principally in the stratum spinosum of the epidermis, but they also occur in other stratified epithelia and have been identified in the lung, lymph nodes, spleen, and thymus
Number of paths to term:	31

denotes an 'is-a' relationship
denotes a 'part-of' relationship

mammalian phenotype

hematopoietic system phenotype

abnormal hematopoietic system morphology/development

abnormal blood cell morphology/development

abnormal hematopoiesis

abnormal hematopoietic cell number

abnormal dendritic cell number

abnormal myeloid dendritic cell number

decreased myeloid dendritic cell number

decreased Langerhans cell number

absent Langerhans cell [MP:0008118] (12 genotypes, 12 annotations)

mammalian phenotype

hematopoietic system phenotype

abnormal hematopoietic system morphology/development

abnormal blood cell morphology/development

abnormal hematopoiesis

abnormal hematopoietic cell number

abnormal dendritic cell number

decreased dendritic cell number

decreased myeloid dendritic cell number

decreased Langerhans cell number

absent Langerhans cell [MP:0008118] (12 genotypes, 12 annotations)

mammalian phenotype

hematopoietic system phenotype

abnormal hematopoietic system morphology/development

abnormal blood cell morphology/development

abnormal hematopoiesis

abnormal hematopoietic cell number

decreased hematopoietic cell number

decreased dendritic cell number

decreased myeloid dendritic cell number

decreased Langerhans cell number

absent Langerhans cell [MP:0008118] (12 genotypes, 12 annotations)

mammalian phenotype

hematopoietic system phenotype

abnormal hematopoietic system morphology/development

abnormal blood cell morphology/development

abnormal hematopoiesis

abnormal leukocyte morphology

abnormal dendritic cell morphology

abnormal dendritic cell number

abnormal myeloid dendritic cell number

decreased myeloid dendritic cell number

decreased Langerhans cell number

absent Langerhans cell [MP:0008118] (12 genotypes, 12 annotations)

mammalian phenotype

hematopoietic system phenotype

abnormal hematopoietic system morphology/development

abnormal blood cell morphology/development

abnormal hematopoiesis

abnormal leukocyte morphology

abnormal dendritic cell morphology

abnormal dendritic cell number

decreased dendritic cell number

decreased myeloid dendritic cell number

decreased Langerhans cell number

absent Langerhans cell [MP:0008118] (12 genotypes, 12 annotations)

mammalian phenotype

hematopoietic system phenotype

abnormal hematopoietic system morphology/development

abnormal blood cell morphology/development

abnormal hematopoiesis

abnormal leukocyte morphology

abnormal dendritic cell morphology

abnormal myeloid dendritic cell morphology

abnormal Langerhans cell morphology

decreased Langerhans cell number

absent Langerhans cell [MP:0008118] (12 genotypes, 12 annotations)

mammalian phenotype

hematopoietic system phenotype

abnormal hematopoietic system morphology/development

abnormal blood cell morphology/development

abnormal hematopoiesis

abnormal leukocyte morphology

abnormal dendritic cell morphology

abnormal myeloid dendritic cell morphology

abnormal myeloid dendritic cell number

decreased myeloid dendritic cell number

decreased Langerhans cell number

absent Langerhans cell [MP:0008118] (12 genotypes, 12 annotations)

mammalian phenotype

hematopoietic system phenotype

abnormal hematopoietic system morphology/development

abnormal blood cell morphology/development

abnormal hematopoiesis

abnormal leukocyte morphology

abnormal mononuclear cell morphology

abnormal mononuclear phagocyte morphology

abnormal myeloid dendritic cell morphology

abnormal Langerhans cell morphology

decreased Langerhans cell number

absent Langerhans cell [MP:0008118] (12 genotypes, 12 annotations)

mammalian phenotype

hematopoietic system phenotype

abnormal hematopoietic system morphology/development

abnormal blood cell morphology/development

abnormal hematopoiesis

abnormal leukocyte morphology

abnormal mononuclear cell morphology

abnormal mononuclear phagocyte morphology

abnormal myeloid dendritic cell morphology

abnormal myeloid dendritic cell number

decreased myeloid dendritic cell number

decreased Langerhans cell number

absent Langerhans cell [MP:0008118] (12 genotypes, 12 annotations)

mammalian phenotype

hematopoietic system phenotype

abnormal hematopoietic system morphology/development

abnormal blood cell morphology/development

abnormal hematopoiesis

abnormal leukocyte morphology

abnormal myeloid leukocyte morphology

abnormal phagocyte morphology

abnormal mononuclear phagocyte morphology

abnormal myeloid dendritic cell morphology

abnormal Langerhans cell morphology

decreased Langerhans cell number

absent Langerhans cell [MP:0008118] (12 genotypes, 12 annotations)

mammalian phenotype

hematopoietic system phenotype

abnormal hematopoietic system morphology/development

abnormal blood cell morphology/development

abnormal hematopoiesis

abnormal leukocyte morphology

abnormal myeloid leukocyte morphology

abnormal phagocyte morphology

abnormal mononuclear phagocyte morphology

abnormal myeloid dendritic cell morphology

abnormal myeloid dendritic cell number

decreased myeloid dendritic cell number

decreased Langerhans cell number

absent Langerhans cell [MP:0008118] (12 genotypes, 12 annotations)

mammalian phenotype

hematopoietic system phenotype

abnormal hematopoietic system morphology/development

abnormal blood cell morphology/development

abnormal leukocyte morphology

abnormal dendritic cell morphology

abnormal dendritic cell number

abnormal myeloid dendritic cell number

decreased myeloid dendritic cell number

decreased Langerhans cell number

absent Langerhans cell [MP:0008118] (12 genotypes, 12 annotations)

mammalian phenotype

hematopoietic system phenotype

abnormal hematopoietic system morphology/development

abnormal blood cell morphology/development

abnormal leukocyte morphology

abnormal dendritic cell morphology

abnormal dendritic cell number

decreased dendritic cell number

decreased myeloid dendritic cell number

decreased Langerhans cell number

absent Langerhans cell [MP:0008118] (12 genotypes, 12 annotations)

mammalian phenotype

hematopoietic system phenotype

abnormal hematopoietic system morphology/development

abnormal blood cell morphology/development

abnormal leukocyte morphology

abnormal dendritic cell morphology

abnormal myeloid dendritic cell morphology

abnormal Langerhans cell morphology

decreased Langerhans cell number

absent Langerhans cell [MP:0008118] (12 genotypes, 12 annotations)

mammalian phenotype

hematopoietic system phenotype

abnormal hematopoietic system morphology/development

abnormal blood cell morphology/development

abnormal leukocyte morphology

abnormal dendritic cell morphology

abnormal myeloid dendritic cell morphology

abnormal myeloid dendritic cell number

decreased myeloid dendritic cell number

decreased Langerhans cell number

absent Langerhans cell [MP:0008118] (12 genotypes, 12 annotations)

mammalian phenotype

hematopoietic system phenotype

abnormal hematopoietic system morphology/development

abnormal blood cell morphology/development

abnormal leukocyte morphology

abnormal mononuclear cell morphology

abnormal mononuclear phagocyte morphology

abnormal myeloid dendritic cell morphology

abnormal Langerhans cell morphology

decreased Langerhans cell number

absent Langerhans cell [MP:0008118] (12 genotypes, 12 annotations)

mammalian phenotype

hematopoietic system phenotype

abnormal hematopoietic system morphology/development

abnormal blood cell morphology/development

abnormal leukocyte morphology

abnormal mononuclear cell morphology

abnormal mononuclear phagocyte morphology

abnormal myeloid dendritic cell morphology

abnormal myeloid dendritic cell number

decreased myeloid dendritic cell number

decreased Langerhans cell number

absent Langerhans cell [MP:0008118] (12 genotypes, 12 annotations)

mammalian phenotype

hematopoietic system phenotype

abnormal hematopoietic system morphology/development

abnormal blood cell morphology/development

abnormal leukocyte morphology

abnormal myeloid leukocyte morphology

abnormal phagocyte morphology

abnormal mononuclear phagocyte morphology

abnormal myeloid dendritic cell morphology

abnormal Langerhans cell morphology

decreased Langerhans cell number

absent Langerhans cell [MP:0008118] (12 genotypes, 12 annotations)

mammalian phenotype

hematopoietic system phenotype

abnormal hematopoietic system morphology/development

abnormal blood cell morphology/development

abnormal leukocyte morphology

abnormal myeloid leukocyte morphology

abnormal phagocyte morphology

abnormal mononuclear phagocyte morphology

abnormal myeloid dendritic cell morphology

abnormal myeloid dendritic cell number

decreased myeloid dendritic cell number

decreased Langerhans cell number

absent Langerhans cell [MP:0008118] (12 genotypes, 12 annotations)

mammalian phenotype

immune system phenotype

abnormal immune system morphology

abnormal immune system cell morphology

abnormal leukocyte morphology

abnormal dendritic cell morphology

abnormal dendritic cell number

abnormal myeloid dendritic cell number

decreased myeloid dendritic cell number

decreased Langerhans cell number

absent Langerhans cell [MP:0008118] (12 genotypes, 12 annotations)

mammalian phenotype

immune system phenotype

abnormal immune system morphology

abnormal immune system cell morphology

abnormal leukocyte morphology

abnormal dendritic cell morphology

abnormal dendritic cell number

decreased dendritic cell number

decreased myeloid dendritic cell number

decreased Langerhans cell number

absent Langerhans cell [MP:0008118] (12 genotypes, 12 annotations)

mammalian phenotype

immune system phenotype

abnormal immune system morphology

abnormal immune system cell morphology

abnormal leukocyte morphology

abnormal dendritic cell morphology

abnormal myeloid dendritic cell morphology

abnormal Langerhans cell morphology

decreased Langerhans cell number

absent Langerhans cell [MP:0008118] (12 genotypes, 12 annotations)

mammalian phenotype

immune system phenotype

abnormal immune system morphology

abnormal immune system cell morphology

abnormal leukocyte morphology

abnormal dendritic cell morphology

abnormal myeloid dendritic cell morphology

abnormal myeloid dendritic cell number

decreased myeloid dendritic cell number

decreased Langerhans cell number

absent Langerhans cell [MP:0008118] (12 genotypes, 12 annotations)

mammalian phenotype

immune system phenotype

abnormal immune system morphology

abnormal immune system cell morphology

abnormal leukocyte morphology

abnormal mononuclear cell morphology

abnormal mononuclear phagocyte morphology

abnormal myeloid dendritic cell morphology

abnormal Langerhans cell morphology

decreased Langerhans cell number

absent Langerhans cell [MP:0008118] (12 genotypes, 12 annotations)

mammalian phenotype

immune system phenotype

abnormal immune system morphology

abnormal immune system cell morphology

abnormal leukocyte morphology

abnormal mononuclear cell morphology

abnormal mononuclear phagocyte morphology

abnormal myeloid dendritic cell morphology

abnormal myeloid dendritic cell number

decreased myeloid dendritic cell number

decreased Langerhans cell number

absent Langerhans cell [MP:0008118] (12 genotypes, 12 annotations)

mammalian phenotype

immune system phenotype

abnormal immune system morphology

abnormal immune system cell morphology

abnormal leukocyte morphology

abnormal myeloid leukocyte morphology

abnormal phagocyte morphology

abnormal mononuclear phagocyte morphology

abnormal myeloid dendritic cell morphology

abnormal Langerhans cell morphology

decreased Langerhans cell number

absent Langerhans cell [MP:0008118] (12 genotypes, 12 annotations)

mammalian phenotype

immune system phenotype

abnormal immune system morphology

abnormal immune system cell morphology

abnormal leukocyte morphology

abnormal myeloid leukocyte morphology

abnormal phagocyte morphology

abnormal mononuclear phagocyte morphology

abnormal myeloid dendritic cell morphology

abnormal myeloid dendritic cell number

decreased myeloid dendritic cell number

decreased Langerhans cell number

absent Langerhans cell [MP:0008118] (12 genotypes, 12 annotations)

mammalian phenotype

immune system phenotype

abnormal immune system morphology

abnormal immune system cell morphology

abnormal professional antigen presenting cell morphology

abnormal dendritic cell morphology

abnormal dendritic cell number

abnormal myeloid dendritic cell number

decreased myeloid dendritic cell number

decreased Langerhans cell number

absent Langerhans cell [MP:0008118] (12 genotypes, 12 annotations)

mammalian phenotype

immune system phenotype

abnormal immune system morphology

abnormal immune system cell morphology

abnormal professional antigen presenting cell morphology

abnormal dendritic cell morphology

abnormal dendritic cell number

decreased dendritic cell number

decreased myeloid dendritic cell number

decreased Langerhans cell number

absent Langerhans cell [MP:0008118] (12 genotypes, 12 annotations)

mammalian phenotype

immune system phenotype

abnormal immune system morphology

abnormal immune system cell morphology

abnormal professional antigen presenting cell morphology

abnormal dendritic cell morphology

abnormal myeloid dendritic cell morphology

abnormal Langerhans cell morphology

decreased Langerhans cell number

absent Langerhans cell [MP:0008118] (12 genotypes, 12 annotations)

mammalian phenotype

immune system phenotype

abnormal immune system morphology

abnormal immune system cell morphology

abnormal professional antigen presenting cell morphology

abnormal dendritic cell morphology

abnormal myeloid dendritic cell morphology

abnormal myeloid dendritic cell number

decreased myeloid dendritic cell number

decreased Langerhans cell number

absent Langerhans cell [MP:0008118] (12 genotypes, 12 annotations)

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Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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