MGI 5.13 - Phenotype Browser

Mammalian Phenotype Browser
Term Detail

MP term:	abnormal intercalated disc morphology
MP id:	MP:0006267
Definition:	any structural anomaly in the electron dense junctional complex, at the end to end contacts of cardiac muscle cells, that contains two types of membrane junctions i.e. gap junctions and desmosomes; the intercalated discs permit communication between the cells such that there is a sequential contraction of the cells from the bottom of the ventricle to the top, facilitating maximal ejection of blood from the ventricle during contraction
Number of paths to term:	3

denotes an 'is-a' relationship
denotes a 'part-of' relationship

mammalian phenotype

cardiovascular system phenotype

abnormal cardiovascular system morphology

abnormal heart morphology

abnormal heart layer morphology

abnormal myocardium layer morphology

abnormal myocardial fiber morphology

abnormal intercalated disc morphology [MP:0006267] (24 genotypes, 24 annotations)

absent intercalated discs

absent cardiac desmosomes

decreased myocardial fiber number

enlarged myocardial fiber

increased myocardial fiber number

myocardial fiber degeneration

mammalian phenotype

muscle phenotype

abnormal muscle morphology

abnormal cardiac muscle tissue morphology

abnormal myocardial fiber morphology

abnormal intercalated disc morphology [MP:0006267] (24 genotypes, 24 annotations)

absent intercalated discs

absent cardiac desmosomes

decreased myocardial fiber number

enlarged myocardial fiber

increased myocardial fiber number

myocardial fiber degeneration

mammalian phenotype

muscle phenotype

abnormal muscle morphology

abnormal muscle fiber morphology

abnormal myocardial fiber morphology

abnormal intercalated disc morphology [MP:0006267] (24 genotypes, 24 annotations)

absent intercalated discs

absent cardiac desmosomes

decreased myocardial fiber number

enlarged myocardial fiber

increased myocardial fiber number

myocardial fiber degeneration

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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