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Mammalian Phenotype Browser
Term Detail
MP term:abnormal intercalated disc morphology
MP id: MP:0006267
Definition: any structural anomaly in the electron dense junctional complex, at the end to end contacts of cardiac muscle cells, that contains two types of membrane junctions i.e. gap junctions and desmosomes; the intercalated discs permit communication between the cells such that there is a sequential contraction of the cells from the bottom of the ventricle to the top, facilitating maximal ejection of blood from the ventricle during contraction
Number of paths to term: 3

is-adenotes an 'is-a' relationship
part-ofdenotes a 'part-of' relationship


mammalian phenotype
        is-acardiovascular system phenotype
                is-aabnormal cardiovascular system morphology
                        is-aabnormal heart morphology
                                is-aabnormal heart layer morphology
                                        is-aabnormal myocardium layer morphology
                                                is-aabnormal myocardial fiber morphology
                                                        is-aabnormal intercalated disc morphology [MP:0006267] (25 genotypes, 25 annotations)
                                                                is-aabsent intercalated discs
                                                        is-aabsent cardiac desmosomes
                                                        is-adecreased myocardial fiber number
                                                        is-aenlarged myocardial fiber
                                                        is-aincreased myocardial fiber number
                                                        is-amyocardial fiber degeneration
                                                        is-asmall myocardial fiber


mammalian phenotype
        is-amuscle phenotype
                is-aabnormal muscle morphology
                        is-aabnormal cardiac muscle tissue morphology
                                is-aabnormal myocardial fiber morphology
                                        is-aabnormal intercalated disc morphology [MP:0006267] (25 genotypes, 25 annotations)
                                                is-aabsent intercalated discs
                                        is-aabsent cardiac desmosomes
                                        is-adecreased myocardial fiber number
                                        is-aenlarged myocardial fiber
                                        is-aincreased myocardial fiber number
                                        is-amyocardial fiber degeneration
                                        is-asmall myocardial fiber


mammalian phenotype
        is-amuscle phenotype
                is-aabnormal muscle morphology
                        is-aabnormal muscle fiber morphology
                                is-aabnormal myocardial fiber morphology
                                        is-aabnormal intercalated disc morphology [MP:0006267] (25 genotypes, 25 annotations)
                                                is-aabsent intercalated discs
                                        is-aabsent cardiac desmosomes
                                        is-adecreased myocardial fiber number
                                        is-aenlarged myocardial fiber
                                        is-aincreased myocardial fiber number
                                        is-amyocardial fiber degeneration
                                        is-asmall myocardial fiber

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last database update
11/18/2014
MGI 5.20
The Jackson Laboratory