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Mammalian Phenotype Browser
Term Detail
MP term:abnormal mesangial cell morphology
Synonym: abnormal deep cell
Synonym: abnormal intercapillary cell
Synonym: abnormal intraglomerular mesangial cell
MP id: MP:0005327
Definition: any structural anomaly of the modified smooth muscle cells that are interposed between endothelial cells and the basement membrane in the central or stalk region of the capillary tuft of the renal glomerulus, which regulate blood flow by their contractile activity, and secrete extracellular matrix, prostaglandins, and cytokines; mesangial cells also have phagocytic activity, removing proteins and other molecules trapped in the glomerular basement membrane or filtration barrier
Number of paths to term: 2

is-adenotes an 'is-a' relationship
part-ofdenotes a 'part-of' relationship


mammalian phenotype
        is-arenal/urinary system phenotype
                is-aabnormal renal/urinary system morphology
                        is-aabnormal kidney morphology
                                is-aabnormal kidney cortex morphology
                                        is-aabnormal renal corpuscle morphology
                                                is-aabnormal renal glomerulus morphology
                                                        is-aabnormal glomerular mesangium morphology
                                                                is-aabnormal mesangial cell morphology [MP:0005327] (75 genotypes, 83 annotations)
                                                                        is-aabsent mesangial cell
                                                                        is-amesangial cell hyperplasia
                                                                        is-amesangial cell hypoplasia
                                                                        is-amesangial cell interposition
                                                                is-aabnormal mesangial matrix morphology +
                                                                is-amesangiolysis


mammalian phenotype
        is-arenal/urinary system phenotype
                is-aabnormal renal/urinary system morphology
                        is-aabnormal kidney morphology
                                is-aabnormal nephron morphology
                                        is-aabnormal renal corpuscle morphology
                                                is-aabnormal renal glomerulus morphology
                                                        is-aabnormal glomerular mesangium morphology
                                                                is-aabnormal mesangial cell morphology [MP:0005327] (75 genotypes, 83 annotations)
                                                                        is-aabsent mesangial cell
                                                                        is-amesangial cell hyperplasia
                                                                        is-amesangial cell hypoplasia
                                                                        is-amesangial cell interposition
                                                                is-aabnormal mesangial matrix morphology +
                                                                is-amesangiolysis

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last database update
11/18/2014
MGI 5.20
The Jackson Laboratory