MGI 5.13 - Phenotype Browser

Mammalian Phenotype Browser
Term Detail

MP term:	abnormal mesangial cell morphology
Synonym:	abnormal deep cell
Synonym:	abnormal intercapillary cell
Synonym:	abnormal intraglomerular mesangial cell
MP id:	MP:0005327
Definition:	any structural anomaly of the modified smooth muscle cells that are interposed between endothelial cells and the basement membrane in the central or stalk region of the capillary tuft of the renal glomerulus, which regulate blood flow by their contractile activity, and secrete extracellular matrix, prostaglandins, and cytokines; mesangial cells also have phagocytic activity, removing proteins and other molecules trapped in the glomerular basement membrane or filtration barrier
Number of paths to term:	2

denotes an 'is-a' relationship
denotes a 'part-of' relationship

mammalian phenotype

renal/urinary system phenotype

abnormal renal/urinary system morphology

abnormal kidney morphology

abnormal kidney cortex morphology

abnormal renal corpuscle morphology

abnormal renal glomerulus morphology

abnormal glomerular mesangium morphology

abnormal mesangial cell morphology [MP:0005327] (74 genotypes, 82 annotations)

absent mesangial cell

mesangial cell hyperplasia

mesangial cell hypoplasia

mesangial cell interposition

abnormal mesangial matrix morphology +