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Mammalian Phenotype Browser
Term Detail
MP term:abnormal regulatory T cell morphology
Synonym: abnormal regulatory T-cell morphology
Synonym: abnormal regulatory T-lymphocyte
Synonym: abnormal regulatory T lymphocyte morphology
Synonym: abnormal suppressor T cell morphology
Synonym: abnormal suppressor T-cell morphology
Synonym: abnormal suppressor T cell morphology/development
Synonym: abnormal suppressor T lymphocyte morphology
Synonym: abnormal suppressor T-lymphocyte morphology
Synonym: abnormal Treg cell morphology
Synonym: suppressor T cell abnormalities
Synonym: suppressor T-cell abnormalities
MP id: MP:0004941
Alternate id: MP:0002437
Definition: any structural anomaly of the specialized subpopulation of T cells that act to suppress activation of the immune system and thus maintain immune system homeostasis and prevent pathological self-reactivity; these may include T cells that express the CD8 transmembrane glycoprotein (CD8-positive T cells), those that express CD4 and CD25 (CD4-positive, CD25-positive regulatory T cells or Tregs) and other T cell types that have suppressor function
Number of paths to term: 2

is-adenotes an 'is-a' relationship
part-ofdenotes a 'part-of' relationship


mammalian phenotype
        is-ahematopoietic system phenotype
                is-aabnormal hematopoietic system morphology/development
                        is-aabnormal blood cell morphology/development
                                is-aabnormal hematopoiesis
                                        is-aabnormal leukocyte morphology
                                                is-aabnormal mononuclear cell morphology
                                                        is-aabnormal lymphocyte morphology
                                                                is-aabnormal T cell morphology
                                                                        is-aabnormal alpha-beta T cell morphology +
                                                                        is-aabnormal effector T cell morphology +
                                                                        is-aabnormal gamma-delta T cell morphology +
                                                                        is-aabnormal intraepithelial T cell morphology +
                                                                        is-aabnormal memory T cell morphology +
                                                                        is-aabnormal NK T cell morphology +
                                                                        is-aabnormal regulatory T cell morphology [MP:0004941] (146 genotypes, 160 annotations)
                                                                                is-aabnormal CD4-positive, CD25-positive, alpha-beta regulatory T cell morphology
                                                                                is-aabnormal CD8-positive, alpha-beta regulatory T cell morphology
                                                                                is-aabnormal regulatory T cell number +
                                                                        is-aabnormal T cell differentiation +
                                                                        is-aabnormal T cell number +


mammalian phenotype
        is-aimmune system phenotype
                is-aabnormal immune system morphology
                        is-aabnormal immune system cell morphology
                                is-aabnormal leukocyte morphology
                                        is-aabnormal mononuclear cell morphology
                                                is-aabnormal lymphocyte morphology
                                                        is-aabnormal T cell morphology
                                                                is-aabnormal alpha-beta T cell morphology +
                                                                is-aabnormal effector T cell morphology +
                                                                is-aabnormal gamma-delta T cell morphology +
                                                                is-aabnormal intraepithelial T cell morphology +
                                                                is-aabnormal memory T cell morphology +
                                                                is-aabnormal NK T cell morphology +
                                                                is-aabnormal regulatory T cell morphology [MP:0004941] (146 genotypes, 160 annotations)
                                                                        is-aabnormal CD4-positive, CD25-positive, alpha-beta regulatory T cell morphology
                                                                        is-aabnormal CD8-positive, alpha-beta regulatory T cell morphology
                                                                        is-aabnormal regulatory T cell number +
                                                                is-aabnormal T cell differentiation +
                                                                is-aabnormal T cell number +

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last database update
07/15/2014
MGI 5.18
The Jackson Laboratory