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Mammalian Phenotype Browser
Term Detail
MP term:abnormal class switch recombination
Synonym: abnormal CSR
Synonym: abnormal isotype switching
MP id: MP:0004816
Definition: anomaly in the rearrangement of the heavy chain genes of differentiating B cells such that the initially encoded heavy chain IgM molecule is altered to one encoding IgG, IgA or IgE; normally, this allows the body to produce antibodies with different effector functions
Number of paths to term: 14

is-adenotes an 'is-a' relationship
part-ofdenotes a 'part-of' relationship


mammalian phenotype
        is-ahematopoietic system phenotype
                is-aabnormal hematopoietic system morphology/development
                        is-aabnormal blood cell morphology/development
                                is-aabnormal hematopoiesis
                                        is-aabnormal leukocyte morphology
                                                is-aabnormal mononuclear cell morphology
                                                        is-aabnormal lymphocyte morphology
                                                                is-aabnormal B cell morphology
                                                                        is-aabnormal B cell differentiation
                                                                                is-aabnormal B cell activation +
                                                                                is-aabnormal B cell receptor editing
                                                                                is-aabnormal B cell selection +
                                                                                is-aabnormal class switch recombination [MP:0004816] (163 genotypes, 163 annotations)
                                                                                is-aabnormal immature B cell morphology +
                                                                                is-aabnormal immunoglobulin V(D)J recombination +
                                                                                is-aabnormal memory B cell differentiation
                                                                                is-aabnormal plasma cell differentiation
                                                                                is-aabnormal pro-B cell morphology +
                                                                                is-aabnormal somatic hypermutation frequency
                                                                                is-aarrested B cell differentiation


mammalian phenotype
        is-ahematopoietic system phenotype
                is-aabnormal hematopoietic system morphology/development
                        is-aabnormal blood cell morphology/development
                                is-aabnormal hematopoiesis
                                        is-aabnormal leukocyte morphology
                                                is-aabnormal mononuclear cell morphology
                                                        is-aabnormal lymphocyte morphology
                                                                is-aabnormal lymphopoiesis
                                                                        is-aabnormal B cell differentiation
                                                                                is-aabnormal B cell activation +
                                                                                is-aabnormal B cell receptor editing
                                                                                is-aabnormal B cell selection +
                                                                                is-aabnormal class switch recombination [MP:0004816] (163 genotypes, 163 annotations)
                                                                                is-aabnormal immature B cell morphology +
                                                                                is-aabnormal immunoglobulin V(D)J recombination +
                                                                                is-aabnormal memory B cell differentiation
                                                                                is-aabnormal plasma cell differentiation
                                                                                is-aabnormal pro-B cell morphology +
                                                                                is-aabnormal somatic hypermutation frequency
                                                                                is-aarrested B cell differentiation


mammalian phenotype
        is-ahematopoietic system phenotype
                is-aabnormal hematopoietic system morphology/development
                        is-aabnormal blood cell morphology/development
                                is-aabnormal hematopoiesis
                                        is-aabnormal leukopoiesis
                                                is-aabnormal lymphopoiesis
                                                        is-aabnormal B cell differentiation
                                                                is-aabnormal B cell activation +
                                                                is-aabnormal B cell receptor editing
                                                                is-aabnormal B cell selection +
                                                                is-aabnormal class switch recombination [MP:0004816] (163 genotypes, 163 annotations)
                                                                is-aabnormal immature B cell morphology +
                                                                is-aabnormal immunoglobulin V(D)J recombination +
                                                                is-aabnormal memory B cell differentiation
                                                                is-aabnormal plasma cell differentiation
                                                                is-aabnormal pro-B cell morphology +
                                                                is-aabnormal somatic hypermutation frequency
                                                                is-aarrested B cell differentiation


mammalian phenotype
        is-ahematopoietic system phenotype
                is-aabnormal hematopoietic system physiology
                        is-aabnormal blood cell physiology
                                is-aabnormal leukocyte physiology
                                        is-aabnormal lymphocyte physiology
                                                is-aabnormal B cell physiology
                                                        is-aabnormal B cell activation +
                                                        is-aabnormal B cell apoptosis +
                                                        is-aabnormal B lymphocyte antigen presentation +
                                                        is-aabnormal class switch recombination [MP:0004816] (163 genotypes, 163 annotations)
                                                        is-aabnormal follicular B cell physiology
                                                        is-aabnormal germinal center B cell physiology
                                                        is-aabnormal immunoglobulin level +
                                                        is-aabnormal marginal zone B cell physiology
                                                        is-aabnormal memory B cell physiology


mammalian phenotype
        is-aimmune system phenotype
                is-aabnormal immune system morphology
                        is-aabnormal immune system cell morphology
                                is-aabnormal leukocyte morphology
                                        is-aabnormal mononuclear cell morphology
                                                is-aabnormal lymphocyte morphology
                                                        is-aabnormal B cell morphology
                                                                is-aabnormal B cell differentiation
                                                                        is-aabnormal B cell activation +
                                                                        is-aabnormal B cell receptor editing
                                                                        is-aabnormal B cell selection +
                                                                        is-aabnormal class switch recombination [MP:0004816] (163 genotypes, 163 annotations)
                                                                        is-aabnormal immature B cell morphology +
                                                                        is-aabnormal immunoglobulin V(D)J recombination +
                                                                        is-aabnormal memory B cell differentiation
                                                                        is-aabnormal plasma cell differentiation
                                                                        is-aabnormal pro-B cell morphology +
                                                                        is-aabnormal somatic hypermutation frequency
                                                                        is-aarrested B cell differentiation


mammalian phenotype
        is-aimmune system phenotype
                is-aabnormal immune system morphology
                        is-aabnormal immune system cell morphology
                                is-aabnormal leukocyte morphology
                                        is-aabnormal mononuclear cell morphology
                                                is-aabnormal lymphocyte morphology
                                                        is-aabnormal lymphopoiesis
                                                                is-aabnormal B cell differentiation
                                                                        is-aabnormal B cell activation +
                                                                        is-aabnormal B cell receptor editing
                                                                        is-aabnormal B cell selection +
                                                                        is-aabnormal class switch recombination [MP:0004816] (163 genotypes, 163 annotations)
                                                                        is-aabnormal immature B cell morphology +
                                                                        is-aabnormal immunoglobulin V(D)J recombination +
                                                                        is-aabnormal memory B cell differentiation
                                                                        is-aabnormal plasma cell differentiation
                                                                        is-aabnormal pro-B cell morphology +
                                                                        is-aabnormal somatic hypermutation frequency
                                                                        is-aarrested B cell differentiation


mammalian phenotype
        is-aimmune system phenotype
                is-aabnormal immune system morphology
                        is-aabnormal immune system cell morphology
                                is-aabnormal leukopoiesis
                                        is-aabnormal lymphopoiesis
                                                is-aabnormal B cell differentiation
                                                        is-aabnormal B cell activation +
                                                        is-aabnormal B cell receptor editing
                                                        is-aabnormal B cell selection +
                                                        is-aabnormal class switch recombination [MP:0004816] (163 genotypes, 163 annotations)
                                                        is-aabnormal immature B cell morphology +
                                                        is-aabnormal immunoglobulin V(D)J recombination +
                                                        is-aabnormal memory B cell differentiation
                                                        is-aabnormal plasma cell differentiation
                                                        is-aabnormal pro-B cell morphology +
                                                        is-aabnormal somatic hypermutation frequency
                                                        is-aarrested B cell differentiation


mammalian phenotype
        is-aimmune system phenotype
                is-aabnormal immune system physiology
                        is-aabnormal adaptive immunity
                                is-aabnormal class switch recombination [MP:0004816] (163 genotypes, 163 annotations)
                                is-aabnormal leukocyte physiology +
                                is-aabnormal professional antigen presenting cell physiology +
                                is-aabnormal somatic hypermutation frequency
                                is-aabnormal type I hypersensitivity reaction +
                                is-aabnormal type II hypersensitivity reaction +
                                is-aabnormal type III hypersensitivity reaction +
                                is-aabnormal type IV hypersensitivity reaction +


mammalian phenotype
        is-aimmune system phenotype
                is-aabnormal immune system physiology
                        is-aabnormal adaptive immunity
                                is-aabnormal leukocyte physiology
                                        is-aabnormal lymphocyte physiology
                                                is-aabnormal B cell physiology
                                                        is-aabnormal B cell activation +
                                                        is-aabnormal B cell apoptosis +
                                                        is-aabnormal B lymphocyte antigen presentation +
                                                        is-aabnormal class switch recombination [MP:0004816] (163 genotypes, 163 annotations)
                                                        is-aabnormal follicular B cell physiology
                                                        is-aabnormal germinal center B cell physiology
                                                        is-aabnormal immunoglobulin level +
                                                        is-aabnormal marginal zone B cell physiology
                                                        is-aabnormal memory B cell physiology


mammalian phenotype
        is-aimmune system phenotype
                is-aabnormal immune system physiology
                        is-aabnormal adaptive immunity
                                is-aabnormal professional antigen presenting cell physiology
                                        is-aabnormal B cell physiology
                                                is-aabnormal B cell activation +
                                                is-aabnormal B cell apoptosis +
                                                is-aabnormal B lymphocyte antigen presentation +
                                                is-aabnormal class switch recombination [MP:0004816] (163 genotypes, 163 annotations)
                                                is-aabnormal follicular B cell physiology
                                                is-aabnormal germinal center B cell physiology
                                                is-aabnormal immunoglobulin level +
                                                is-aabnormal marginal zone B cell physiology
                                                is-aabnormal memory B cell physiology


mammalian phenotype
        is-aimmune system phenotype
                is-aabnormal immune system physiology
                        is-aabnormal cell-mediated immunity
                                is-aabnormal leukocyte physiology
                                        is-aabnormal lymphocyte physiology
                                                is-aabnormal B cell physiology
                                                        is-aabnormal B cell activation +
                                                        is-aabnormal B cell apoptosis +
                                                        is-aabnormal B lymphocyte antigen presentation +
                                                        is-aabnormal class switch recombination [MP:0004816] (163 genotypes, 163 annotations)
                                                        is-aabnormal follicular B cell physiology
                                                        is-aabnormal germinal center B cell physiology
                                                        is-aabnormal immunoglobulin level +
                                                        is-aabnormal marginal zone B cell physiology
                                                        is-aabnormal memory B cell physiology


mammalian phenotype
        is-aimmune system phenotype
                is-aabnormal immune system physiology
                        is-aabnormal cell-mediated immunity
                                is-aabnormal professional antigen presenting cell physiology
                                        is-aabnormal B cell physiology
                                                is-aabnormal B cell activation +
                                                is-aabnormal B cell apoptosis +
                                                is-aabnormal B lymphocyte antigen presentation +
                                                is-aabnormal class switch recombination [MP:0004816] (163 genotypes, 163 annotations)
                                                is-aabnormal follicular B cell physiology
                                                is-aabnormal germinal center B cell physiology
                                                is-aabnormal immunoglobulin level +
                                                is-aabnormal marginal zone B cell physiology
                                                is-aabnormal memory B cell physiology


mammalian phenotype
        is-aimmune system phenotype
                is-aabnormal immune system physiology
                        is-aabnormal immune cell physiology
                                is-aabnormal leukocyte physiology
                                        is-aabnormal lymphocyte physiology
                                                is-aabnormal B cell physiology
                                                        is-aabnormal B cell activation +
                                                        is-aabnormal B cell apoptosis +
                                                        is-aabnormal B lymphocyte antigen presentation +
                                                        is-aabnormal class switch recombination [MP:0004816] (163 genotypes, 163 annotations)
                                                        is-aabnormal follicular B cell physiology
                                                        is-aabnormal germinal center B cell physiology
                                                        is-aabnormal immunoglobulin level +
                                                        is-aabnormal marginal zone B cell physiology
                                                        is-aabnormal memory B cell physiology


mammalian phenotype
        is-aimmune system phenotype
                is-aabnormal immune system physiology
                        is-aabnormal immune cell physiology
                                is-aabnormal professional antigen presenting cell physiology
                                        is-aabnormal B cell physiology
                                                is-aabnormal B cell activation +
                                                is-aabnormal B cell apoptosis +
                                                is-aabnormal B lymphocyte antigen presentation +
                                                is-aabnormal class switch recombination [MP:0004816] (163 genotypes, 163 annotations)
                                                is-aabnormal follicular B cell physiology
                                                is-aabnormal germinal center B cell physiology
                                                is-aabnormal immunoglobulin level +
                                                is-aabnormal marginal zone B cell physiology
                                                is-aabnormal memory B cell physiology

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last database update
09/09/2014
MGI 5.19
The Jackson Laboratory