| MP term: | abnormal class switch recombination |
| Synonym: | abnormal CSR |
| Synonym: | abnormal isotype switching |
| MP id: | MP:0004816 |
| Definition: | anomaly in the rearrangement of the heavy chain genes of differentiating B cells such that the initially encoded heavy chain IgM molecule is altered to one encoding IgG, IgA or IgE; normally, this allows the body to produce antibodies with different effector functions |
| Number of paths to term: | 19 |
denotes an 'is-a' relationship
denotes a 'part-of' relationship
cellular phenotypeabnormal cell physiologyabnormal cell differentiationabnormal mononuclear cell differentiationabnormal lymphopoiesisabnormal B cell differentiationabnormal B cell activation +abnormal B cell receptor editingabnormal B cell selection +abnormal class switch recombination [MP:0004816] (150 genotypes, 150 annotations)abnormal immature B cell morphology +abnormal immunoglobulin V(D)J recombination +abnormal memory B cell differentiationabnormal plasma cell differentiationabnormal pro-B cell morphology +abnormal somatic hypermutation frequencyarrested B cell differentiationhematopoietic system phenotypeabnormal hematopoietic system morphology/developmentabnormal blood cell morphology/developmentabnormal hematopoiesisabnormal leukocyte morphologyabnormal mononuclear cell morphologyabnormal lymphocyte morphologyabnormal B cell morphologyabnormal B cell differentiationabnormal B cell activation +abnormal B cell receptor editingabnormal B cell selection +abnormal class switch recombination [MP:0004816] (150 genotypes, 150 annotations)abnormal immature B cell morphology +abnormal immunoglobulin V(D)J recombination +abnormal memory B cell differentiationabnormal plasma cell differentiationabnormal pro-B cell morphology +abnormal somatic hypermutation frequencyarrested B cell differentiationhematopoietic system phenotypeabnormal hematopoietic system morphology/developmentabnormal blood cell morphology/developmentabnormal hematopoiesisabnormal leukocyte morphologyabnormal mononuclear cell morphologyabnormal lymphocyte morphologyabnormal lymphopoiesisabnormal B cell differentiationabnormal B cell activation +abnormal B cell receptor editingabnormal B cell selection +abnormal class switch recombination [MP:0004816] (150 genotypes, 150 annotations)abnormal immature B cell morphology +abnormal immunoglobulin V(D)J recombination +abnormal memory B cell differentiationabnormal plasma cell differentiationabnormal pro-B cell morphology +abnormal somatic hypermutation frequencyarrested B cell differentiationhematopoietic system phenotypeabnormal hematopoietic system morphology/developmentabnormal blood cell morphology/developmentabnormal hematopoiesisabnormal leukopoiesisabnormal lymphopoiesisabnormal B cell differentiationabnormal B cell activation +abnormal B cell receptor editingabnormal B cell selection +abnormal class switch recombination [MP:0004816] (150 genotypes, 150 annotations)abnormal immature B cell morphology +abnormal immunoglobulin V(D)J recombination +abnormal memory B cell differentiationabnormal plasma cell differentiationabnormal pro-B cell morphology +abnormal somatic hypermutation frequencyarrested B cell differentiationhematopoietic system phenotypeabnormal hematopoietic system morphology/developmentabnormal blood cell morphology/developmentabnormal hematopoiesisabnormal leukopoiesisabnormal mononuclear cell differentiationabnormal lymphopoiesisabnormal B cell differentiationabnormal B cell activation +abnormal B cell receptor editingabnormal B cell selection +abnormal class switch recombination [MP:0004816] (150 genotypes, 150 annotations)abnormal immature B cell morphology +abnormal immunoglobulin V(D)J recombination +abnormal memory B cell differentiationabnormal plasma cell differentiationabnormal pro-B cell morphology +abnormal somatic hypermutation frequencyarrested B cell differentiationhematopoietic system phenotypeabnormal hematopoietic system morphology/developmentabnormal blood cell morphology/developmentabnormal leukocyte morphologyabnormal mononuclear cell morphologyabnormal lymphocyte morphologyabnormal B cell morphologyabnormal B cell differentiationabnormal B cell activation +abnormal B cell receptor editingabnormal B cell selection +abnormal class switch recombination [MP:0004816] (150 genotypes, 150 annotations)abnormal immature B cell morphology +abnormal immunoglobulin V(D)J recombination +abnormal memory B cell differentiationabnormal plasma cell differentiationabnormal pro-B cell morphology +abnormal somatic hypermutation frequencyarrested B cell differentiationhematopoietic system phenotypeabnormal hematopoietic system morphology/developmentabnormal blood cell morphology/developmentabnormal leukocyte morphologyabnormal mononuclear cell morphologyabnormal lymphocyte morphologyabnormal lymphopoiesisabnormal B cell differentiationabnormal B cell activation +abnormal B cell receptor editingabnormal B cell selection +abnormal class switch recombination [MP:0004816] (150 genotypes, 150 annotations)abnormal immature B cell morphology +abnormal immunoglobulin V(D)J recombination +abnormal memory B cell differentiationabnormal plasma cell differentiationabnormal pro-B cell morphology +abnormal somatic hypermutation frequencyarrested B cell differentiationhematopoietic system phenotypeabnormal hematopoietic system morphology/developmentabnormal bone marrow cell morphology/developmentabnormal myeloblast morphology/developmentabnormal mononuclear cell differentiationabnormal lymphopoiesisabnormal B cell differentiationabnormal B cell activation +abnormal B cell receptor editingabnormal B cell selection +abnormal class switch recombination [MP:0004816] (150 genotypes, 150 annotations)abnormal immature B cell morphology +abnormal immunoglobulin V(D)J recombination +abnormal memory B cell differentiationabnormal plasma cell differentiationabnormal pro-B cell morphology +abnormal somatic hypermutation frequencyarrested B cell differentiationimmune system phenotypeabnormal immune system morphologyabnormal immune system cell morphologyabnormal leukocyte morphologyabnormal mononuclear cell morphologyabnormal lymphocyte morphologyabnormal B cell morphologyabnormal B cell differentiationabnormal B cell activation +abnormal B cell receptor editingabnormal B cell selection +abnormal class switch recombination [MP:0004816] (150 genotypes, 150 annotations)abnormal immature B cell morphology +abnormal immunoglobulin V(D)J recombination +abnormal memory B cell differentiationabnormal plasma cell differentiationabnormal pro-B cell morphology +abnormal somatic hypermutation frequencyarrested B cell differentiationimmune system phenotypeabnormal immune system morphologyabnormal immune system cell morphologyabnormal leukocyte morphologyabnormal mononuclear cell morphologyabnormal lymphocyte morphologyabnormal lymphopoiesisabnormal B cell differentiationabnormal B cell activation +abnormal B cell receptor editingabnormal B cell selection +abnormal class switch recombination [MP:0004816] (150 genotypes, 150 annotations)abnormal immature B cell morphology +abnormal immunoglobulin V(D)J recombination +abnormal memory B cell differentiationabnormal plasma cell differentiationabnormal pro-B cell morphology +abnormal somatic hypermutation frequencyarrested B cell differentiationimmune system phenotypeabnormal immune system morphologyabnormal immune system cell morphologyabnormal leukopoiesisabnormal lymphopoiesisabnormal B cell differentiationabnormal B cell activation +abnormal B cell receptor editingabnormal B cell selection +abnormal class switch recombination [MP:0004816] (150 genotypes, 150 annotations)abnormal immature B cell morphology +abnormal immunoglobulin V(D)J recombination +abnormal memory B cell differentiationabnormal plasma cell differentiationabnormal pro-B cell morphology +abnormal somatic hypermutation frequencyarrested B cell differentiationimmune system phenotypeabnormal immune system morphologyabnormal immune system cell morphologyabnormal leukopoiesisabnormal mononuclear cell differentiationabnormal lymphopoiesisabnormal B cell differentiationabnormal B cell activation +abnormal B cell receptor editingabnormal B cell selection +abnormal class switch recombination [MP:0004816] (150 genotypes, 150 annotations)abnormal immature B cell morphology +abnormal immunoglobulin V(D)J recombination +abnormal memory B cell differentiationabnormal plasma cell differentiationabnormal pro-B cell morphology +abnormal somatic hypermutation frequencyarrested B cell differentiationimmune system phenotypeabnormal immune system physiologyabnormal adaptive immunityabnormal class switch recombination [MP:0004816] (150 genotypes, 150 annotations)abnormal leukocyte physiology +abnormal professional antigen presenting cell physiology +abnormal somatic hypermutation frequencyabnormal type I hypersensitivity reaction +abnormal type II hypersensitivity reaction +abnormal type III hypersensitivity reaction +abnormal type IV hypersensitivity reaction +immune system phenotypeabnormal immune system physiologyabnormal adaptive immunityabnormal leukocyte physiologyabnormal lymphocyte physiologyabnormal B cell physiologyabnormal B cell activation +abnormal B cell apoptosis +abnormal B lymphocyte antigen presentation +abnormal class switch recombination [MP:0004816] (150 genotypes, 150 annotations)abnormal follicular B cell physiologyabnormal germinal center B cell physiologyabnormal immunoglobulin level +abnormal marginal zone B cell physiologyabnormal memory B cell physiologyimmune system phenotypeabnormal immune system physiologyabnormal adaptive immunityabnormal professional antigen presenting cell physiologyabnormal B cell physiologyabnormal B cell activation +abnormal B cell apoptosis +abnormal B lymphocyte antigen presentation +abnormal class switch recombination [MP:0004816] (150 genotypes, 150 annotations)abnormal follicular B cell physiologyabnormal germinal center B cell physiologyabnormal immunoglobulin level +abnormal marginal zone B cell physiologyabnormal memory B cell physiologyimmune system phenotypeabnormal immune system physiologyabnormal cell-mediated immunityabnormal leukocyte physiologyabnormal lymphocyte physiologyabnormal B cell physiologyabnormal B cell activation +abnormal B cell apoptosis +abnormal B lymphocyte antigen presentation +abnormal class switch recombination [MP:0004816] (150 genotypes, 150 annotations)abnormal follicular B cell physiologyabnormal germinal center B cell physiologyabnormal immunoglobulin level +abnormal marginal zone B cell physiologyabnormal memory B cell physiologyimmune system phenotypeabnormal immune system physiologyabnormal cell-mediated immunityabnormal professional antigen presenting cell physiologyabnormal B cell physiologyabnormal B cell activation +abnormal B cell apoptosis +abnormal B lymphocyte antigen presentation +abnormal class switch recombination [MP:0004816] (150 genotypes, 150 annotations)abnormal follicular B cell physiologyabnormal germinal center B cell physiologyabnormal immunoglobulin level +abnormal marginal zone B cell physiologyabnormal memory B cell physiologyimmune system phenotypeabnormal immune system physiologyabnormal immune cell physiologyabnormal leukocyte physiologyabnormal lymphocyte physiologyabnormal B cell physiologyabnormal B cell activation +abnormal B cell apoptosis +abnormal B lymphocyte antigen presentation +abnormal class switch recombination [MP:0004816] (150 genotypes, 150 annotations)abnormal follicular B cell physiologyabnormal germinal center B cell physiologyabnormal immunoglobulin level +abnormal marginal zone B cell physiologyabnormal memory B cell physiologyimmune system phenotypeabnormal immune system physiologyabnormal immune cell physiologyabnormal professional antigen presenting cell physiologyabnormal B cell physiologyabnormal B cell activation +abnormal B cell apoptosis +abnormal B lymphocyte antigen presentation +abnormal class switch recombination [MP:0004816] (150 genotypes, 150 annotations)abnormal follicular B cell physiologyabnormal germinal center B cell physiologyabnormal immunoglobulin level +abnormal marginal zone B cell physiologyabnormal memory B cell physiologyMouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc |
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last database update 05/22/2013 MGI 5.13 |
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