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Mammalian Phenotype Browser
Term Detail
MP term:abnormal proximal convoluted tubule morphology
Synonym: abnormal proximal kidney tubule
Synonym: abnormal proximal renal tubule
Synonym: abnormal proximal tubule
MP id: MP:0004756
Definition: any structural anomaly of the convoluted portion of the duct system of the nephron that extends from the renal glomerular capsule in the kidney cortex into the kidney medulla where it joins the loop of Henle; fluid entering the proximal convoluted tubule is reabsorbed into the peritubular capillaries, including approximately two-thirds of the filtered salt and water and all filtered organic solutes; the most distinctive characteristic of the proximal tubule is its brush border (or striated border), not found in the distal convoluted tubule
Number of paths to term: 1

is-adenotes an 'is-a' relationship
part-ofdenotes a 'part-of' relationship

mammalian phenotype
        is-arenal/urinary system phenotype
                is-aabnormal renal/urinary system morphology
                        is-aabnormal kidney morphology
                                is-aabnormal nephron morphology
                                        is-aabnormal renal tubule morphology
                                                is-aabnormal distal convoluted tubule morphology +
                                                is-aabnormal loop of Henle morphology +
                                                is-aabnormal proximal convoluted tubule morphology [MP:0004756] (118 genotypes, 135 annotations)
                                                        is-aabnormal proximal convoluted tubule brush border morphology +
                                                        is-adilated proximal convoluted tubules
                                                is-aabnormal renal tubule epithelium morphology +
                                                is-aaccumulation of giant lysosomes in kidney/renal tubule cells
                                                is-adecreased renal tubule number
                                                is-adilated renal tubules +
                                                is-arenal tubular necrosis
                                                is-arenal tubule atrophy
                                                is-arenal tubule hypertrophy
                                                is-atubular nephritis

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MGI 6.08
The Jackson Laboratory