| MP term: | abnormal proximal convoluted tubule morphology |
| Synonym: | abnormal proximal kidney tubule |
| Synonym: | abnormal proximal renal tubule |
| Synonym: | abnormal proximal tubule |
| MP id: | MP:0004756 |
| Definition: | any structural anomaly of the convoluted portion of the duct system of the nephron that extends from the renal glomerular capsule in the kidney cortex into the kidney medulla where it joins the loop of Henle; fluid entering the proximal convoluted tubule is reabsorbed into the peritubular capillaries, including approximately two-thirds of the filtered salt and water and all filtered organic solutes; the most distinctive characteristic of the proximal tubule is its brush border (or striated border), not found in the distal convoluted tubule |
| Number of paths to term: | 1 |
denotes an 'is-a' relationship
denotes a 'part-of' relationship
renal/urinary system phenotypeabnormal renal/urinary system morphologyabnormal kidney morphologyabnormal nephron morphologyabnormal renal tubule morphologyabnormal distal convoluted tubule morphology +abnormal loop of Henle morphology +abnormal proximal convoluted tubule morphology [MP:0004756] (107 genotypes, 122 annotations)abnormal proximal convoluted tubule brush border morphology +dilated proximal convoluted tubulesabnormal renal tubule epithelium morphology +accumulation of giant lysosomes in kidney/renal tubule cellsdecreased renal tubule numberdilated renal tubules +renal tubular necrosisrenal tubule atrophyrenal tubule hypertrophytubular nephritisMouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc |
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last database update 05/22/2013 MGI 5.13 |
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