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Mammalian Phenotype Browser
Term Detail
MP term:abnormal inner hair cell stereociliary bundle morphology
Synonym: abnormal IHC bundles
Synonym: abnormal IHC stereocilia
Synonym: abnormal IHC stereociliary bundles
MP id: MP:0004532
Definition: any structural anomaly or disruption of the typically linear or U-shaped pattern of arrangement of mechanosensitive hair bundles located at the apical end of cochlear IHCs; each hair bundle is normally composed of ~100 nonmotile, actin-filled microvilli (stereocilia) arranged in rows of increasing height and coupled to one another by morphologically distinct links: tip links, horizontal top connectors, shaft connectors, and ankle links; most hair bundles also possess a single motile kinocilium immediately adjacent to the tallest row of stereocilia; a fifth link type, the kinocilial link, connects the kinocilium to its neighboring stereocilia
Number of paths to term: 12

is-adenotes an 'is-a' relationship
part-ofdenotes a 'part-of' relationship


mammalian phenotype
        is-ahearing/vestibular/ear phenotype
                is-aabnormal ear morphology
                        is-aabnormal inner ear morphology
                                is-aabnormal cochlea morphology
                                        is-aabnormal cochlear sensory epithelium morphology
                                                is-aabnormal cochlear hair cell morphology
                                                        is-aabnormal cochlear hair cell stereociliary bundle morphology
                                                                is-aabnormal cochlear hair cell inter-stereocilial links morphology +
                                                                is-aabnormal inner hair cell stereociliary bundle morphology [MP:0004532] (68 genotypes, 102 annotations)
                                                                        is-aabnormal inner hair cell kinocilium morphology +
                                                                        is-aabnormal orientation of inner hair cell stereociliary bundles
                                                                        is-aabsent inner hair cell stereocilia
                                                                        is-adecreased inner hair cell stereocilia number
                                                                        is-afused inner hair cell stereocilia
                                                                        is-ashort inner hair cell stereocilia
                                                                is-aabnormal orientation of cochlear hair cell stereociliary bundles +
                                                                is-aabnormal outer hair cell stereociliary bundle morphology +
                                                                is-aabsent cochlear hair cell stereocilia
                                                                is-adecreased cochlear hair cell stereocilia number +
                                                                is-ashort cochlear hair cell stereocilia +
                                                                is-athin cochlear hair cell stereocilia


mammalian phenotype
        is-ahearing/vestibular/ear phenotype
                is-aabnormal ear morphology
                        is-aabnormal inner ear morphology
                                is-aabnormal cochlea morphology
                                        is-aabnormal cochlear sensory epithelium morphology
                                                is-aabnormal cochlear hair cell morphology
                                                        is-aabnormal cochlear inner hair cell morphology
                                                                is-aabnormal cochlear IHC afferent innervation pattern
                                                                is-aabnormal cochlear IHC efferent innervation pattern
                                                                is-aabnormal cochlear inner hair cell number +
                                                                is-aabnormal inner hair cell stereociliary bundle morphology [MP:0004532] (68 genotypes, 102 annotations)
                                                                        is-aabnormal inner hair cell kinocilium morphology +
                                                                        is-aabnormal orientation of inner hair cell stereociliary bundles
                                                                        is-aabsent inner hair cell stereocilia
                                                                        is-adecreased inner hair cell stereocilia number
                                                                        is-afused inner hair cell stereocilia
                                                                        is-ashort inner hair cell stereocilia
                                                                is-aabnormal inner hair cell synaptic ribbon morphology +
                                                                is-acochlear inner hair cell degeneration


mammalian phenotype
        is-ahearing/vestibular/ear phenotype
                is-aabnormal ear morphology
                        is-aabnormal inner ear morphology
                                is-aabnormal cochlea morphology
                                        is-aabnormal scala media morphology
                                                is-aabnormal organ of Corti morphology
                                                        is-aabnormal cochlear hair cell morphology
                                                                is-aabnormal cochlear hair cell stereociliary bundle morphology
                                                                        is-aabnormal cochlear hair cell inter-stereocilial links morphology +
                                                                        is-aabnormal inner hair cell stereociliary bundle morphology [MP:0004532] (68 genotypes, 102 annotations)
                                                                                is-aabnormal inner hair cell kinocilium morphology +
                                                                                is-aabnormal orientation of inner hair cell stereociliary bundles
                                                                                is-aabsent inner hair cell stereocilia
                                                                                is-adecreased inner hair cell stereocilia number
                                                                                is-afused inner hair cell stereocilia
                                                                                is-ashort inner hair cell stereocilia
                                                                        is-aabnormal orientation of cochlear hair cell stereociliary bundles +
                                                                        is-aabnormal outer hair cell stereociliary bundle morphology +
                                                                        is-aabsent cochlear hair cell stereocilia
                                                                        is-adecreased cochlear hair cell stereocilia number +
                                                                        is-ashort cochlear hair cell stereocilia +
                                                                        is-athin cochlear hair cell stereocilia


mammalian phenotype
        is-ahearing/vestibular/ear phenotype
                is-aabnormal ear morphology
                        is-aabnormal inner ear morphology
                                is-aabnormal cochlea morphology
                                        is-aabnormal scala media morphology
                                                is-aabnormal organ of Corti morphology
                                                        is-aabnormal cochlear hair cell morphology
                                                                is-aabnormal cochlear inner hair cell morphology
                                                                        is-aabnormal cochlear IHC afferent innervation pattern
                                                                        is-aabnormal cochlear IHC efferent innervation pattern
                                                                        is-aabnormal cochlear inner hair cell number +
                                                                        is-aabnormal inner hair cell stereociliary bundle morphology [MP:0004532] (68 genotypes, 102 annotations)
                                                                                is-aabnormal inner hair cell kinocilium morphology +
                                                                                is-aabnormal orientation of inner hair cell stereociliary bundles
                                                                                is-aabsent inner hair cell stereocilia
                                                                                is-adecreased inner hair cell stereocilia number
                                                                                is-afused inner hair cell stereocilia
                                                                                is-ashort inner hair cell stereocilia
                                                                        is-aabnormal inner hair cell synaptic ribbon morphology +
                                                                        is-acochlear inner hair cell degeneration


mammalian phenotype
        is-ahearing/vestibular/ear phenotype
                is-aabnormal ear morphology
                        is-aabnormal inner ear morphology
                                is-aabnormal hair cell morphology
                                        is-aabnormal cochlear hair cell morphology
                                                is-aabnormal cochlear hair cell stereociliary bundle morphology
                                                        is-aabnormal cochlear hair cell inter-stereocilial links morphology +
                                                        is-aabnormal inner hair cell stereociliary bundle morphology [MP:0004532] (68 genotypes, 102 annotations)
                                                                is-aabnormal inner hair cell kinocilium morphology +
                                                                is-aabnormal orientation of inner hair cell stereociliary bundles
                                                                is-aabsent inner hair cell stereocilia
                                                                is-adecreased inner hair cell stereocilia number
                                                                is-afused inner hair cell stereocilia
                                                                is-ashort inner hair cell stereocilia
                                                        is-aabnormal orientation of cochlear hair cell stereociliary bundles +
                                                        is-aabnormal outer hair cell stereociliary bundle morphology +
                                                        is-aabsent cochlear hair cell stereocilia
                                                        is-adecreased cochlear hair cell stereocilia number +
                                                        is-ashort cochlear hair cell stereocilia +
                                                        is-athin cochlear hair cell stereocilia


mammalian phenotype
        is-ahearing/vestibular/ear phenotype
                is-aabnormal ear morphology
                        is-aabnormal inner ear morphology
                                is-aabnormal hair cell morphology
                                        is-aabnormal cochlear hair cell morphology
                                                is-aabnormal cochlear inner hair cell morphology
                                                        is-aabnormal cochlear IHC afferent innervation pattern
                                                        is-aabnormal cochlear IHC efferent innervation pattern
                                                        is-aabnormal cochlear inner hair cell number +
                                                        is-aabnormal inner hair cell stereociliary bundle morphology [MP:0004532] (68 genotypes, 102 annotations)
                                                                is-aabnormal inner hair cell kinocilium morphology +
                                                                is-aabnormal orientation of inner hair cell stereociliary bundles
                                                                is-aabsent inner hair cell stereocilia
                                                                is-adecreased inner hair cell stereocilia number
                                                                is-afused inner hair cell stereocilia
                                                                is-ashort inner hair cell stereocilia
                                                        is-aabnormal inner hair cell synaptic ribbon morphology +
                                                        is-acochlear inner hair cell degeneration


mammalian phenotype
        is-ahearing/vestibular/ear phenotype
                is-aabnormal ear morphology
                        is-aabnormal inner ear morphology
                                is-aabnormal membranous labyrinth morphology
                                        is-aabnormal cochlear labyrinth morphology
                                                is-aabnormal scala media morphology
                                                        is-aabnormal organ of Corti morphology
                                                                is-aabnormal cochlear hair cell morphology
                                                                        is-aabnormal cochlear hair cell stereociliary bundle morphology
                                                                                is-aabnormal cochlear hair cell inter-stereocilial links morphology +
                                                                                is-aabnormal inner hair cell stereociliary bundle morphology [MP:0004532] (68 genotypes, 102 annotations)
                                                                                        is-aabnormal inner hair cell kinocilium morphology +
                                                                                        is-aabnormal orientation of inner hair cell stereociliary bundles
                                                                                        is-aabsent inner hair cell stereocilia
                                                                                        is-adecreased inner hair cell stereocilia number
                                                                                        is-afused inner hair cell stereocilia
                                                                                        is-ashort inner hair cell stereocilia
                                                                                is-aabnormal orientation of cochlear hair cell stereociliary bundles +
                                                                                is-aabnormal outer hair cell stereociliary bundle morphology +
                                                                                is-aabsent cochlear hair cell stereocilia
                                                                                is-adecreased cochlear hair cell stereocilia number +
                                                                                is-ashort cochlear hair cell stereocilia +
                                                                                is-athin cochlear hair cell stereocilia


mammalian phenotype
        is-ahearing/vestibular/ear phenotype
                is-aabnormal ear morphology
                        is-aabnormal inner ear morphology
                                is-aabnormal membranous labyrinth morphology
                                        is-aabnormal cochlear labyrinth morphology
                                                is-aabnormal scala media morphology
                                                        is-aabnormal organ of Corti morphology
                                                                is-aabnormal cochlear hair cell morphology
                                                                        is-aabnormal cochlear inner hair cell morphology
                                                                                is-aabnormal cochlear IHC afferent innervation pattern
                                                                                is-aabnormal cochlear IHC efferent innervation pattern
                                                                                is-aabnormal cochlear inner hair cell number +
                                                                                is-aabnormal inner hair cell stereociliary bundle morphology [MP:0004532] (68 genotypes, 102 annotations)
                                                                                        is-aabnormal inner hair cell kinocilium morphology +
                                                                                        is-aabnormal orientation of inner hair cell stereociliary bundles
                                                                                        is-aabsent inner hair cell stereocilia
                                                                                        is-adecreased inner hair cell stereocilia number
                                                                                        is-afused inner hair cell stereocilia
                                                                                        is-ashort inner hair cell stereocilia
                                                                                is-aabnormal inner hair cell synaptic ribbon morphology +
                                                                                is-acochlear inner hair cell degeneration


mammalian phenotype
        is-anervous system phenotype
                is-aabnormal nervous system morphology
                        is-aabnormal neuron morphology
                                is-aabnormal sensory neuron morphology
                                        is-aabnormal mechanoreceptor morphology
                                                is-aabnormal hair cell morphology
                                                        is-aabnormal cochlear hair cell morphology
                                                                is-aabnormal cochlear hair cell stereociliary bundle morphology
                                                                        is-aabnormal cochlear hair cell inter-stereocilial links morphology +
                                                                        is-aabnormal inner hair cell stereociliary bundle morphology [MP:0004532] (68 genotypes, 102 annotations)
                                                                                is-aabnormal inner hair cell kinocilium morphology +
                                                                                is-aabnormal orientation of inner hair cell stereociliary bundles
                                                                                is-aabsent inner hair cell stereocilia
                                                                                is-adecreased inner hair cell stereocilia number
                                                                                is-afused inner hair cell stereocilia
                                                                                is-ashort inner hair cell stereocilia
                                                                        is-aabnormal orientation of cochlear hair cell stereociliary bundles +
                                                                        is-aabnormal outer hair cell stereociliary bundle morphology +
                                                                        is-aabsent cochlear hair cell stereocilia
                                                                        is-adecreased cochlear hair cell stereocilia number +
                                                                        is-ashort cochlear hair cell stereocilia +
                                                                        is-athin cochlear hair cell stereocilia


mammalian phenotype
        is-anervous system phenotype
                is-aabnormal nervous system morphology
                        is-aabnormal neuron morphology
                                is-aabnormal sensory neuron morphology
                                        is-aabnormal mechanoreceptor morphology
                                                is-aabnormal hair cell morphology
                                                        is-aabnormal cochlear hair cell morphology
                                                                is-aabnormal cochlear inner hair cell morphology
                                                                        is-aabnormal cochlear IHC afferent innervation pattern
                                                                        is-aabnormal cochlear IHC efferent innervation pattern
                                                                        is-aabnormal cochlear inner hair cell number +
                                                                        is-aabnormal inner hair cell stereociliary bundle morphology [MP:0004532] (68 genotypes, 102 annotations)
                                                                                is-aabnormal inner hair cell kinocilium morphology +
                                                                                is-aabnormal orientation of inner hair cell stereociliary bundles
                                                                                is-aabsent inner hair cell stereocilia
                                                                                is-adecreased inner hair cell stereocilia number
                                                                                is-afused inner hair cell stereocilia
                                                                                is-ashort inner hair cell stereocilia
                                                                        is-aabnormal inner hair cell synaptic ribbon morphology +
                                                                        is-acochlear inner hair cell degeneration


mammalian phenotype
        is-anervous system phenotype
                is-aabnormal nervous system morphology
                        is-aabnormal somatic nervous system morphology
                                is-aabnormal somatic sensory system morphology
                                        is-aabnormal sensory neuron morphology
                                                is-aabnormal mechanoreceptor morphology
                                                        is-aabnormal hair cell morphology
                                                                is-aabnormal cochlear hair cell morphology
                                                                        is-aabnormal cochlear hair cell stereociliary bundle morphology
                                                                                is-aabnormal cochlear hair cell inter-stereocilial links morphology +
                                                                                is-aabnormal inner hair cell stereociliary bundle morphology [MP:0004532] (68 genotypes, 102 annotations)
                                                                                        is-aabnormal inner hair cell kinocilium morphology +
                                                                                        is-aabnormal orientation of inner hair cell stereociliary bundles
                                                                                        is-aabsent inner hair cell stereocilia
                                                                                        is-adecreased inner hair cell stereocilia number
                                                                                        is-afused inner hair cell stereocilia
                                                                                        is-ashort inner hair cell stereocilia
                                                                                is-aabnormal orientation of cochlear hair cell stereociliary bundles +
                                                                                is-aabnormal outer hair cell stereociliary bundle morphology +
                                                                                is-aabsent cochlear hair cell stereocilia
                                                                                is-adecreased cochlear hair cell stereocilia number +
                                                                                is-ashort cochlear hair cell stereocilia +
                                                                                is-athin cochlear hair cell stereocilia


mammalian phenotype
        is-anervous system phenotype
                is-aabnormal nervous system morphology
                        is-aabnormal somatic nervous system morphology
                                is-aabnormal somatic sensory system morphology
                                        is-aabnormal sensory neuron morphology
                                                is-aabnormal mechanoreceptor morphology
                                                        is-aabnormal hair cell morphology
                                                                is-aabnormal cochlear hair cell morphology
                                                                        is-aabnormal cochlear inner hair cell morphology
                                                                                is-aabnormal cochlear IHC afferent innervation pattern
                                                                                is-aabnormal cochlear IHC efferent innervation pattern
                                                                                is-aabnormal cochlear inner hair cell number +
                                                                                is-aabnormal inner hair cell stereociliary bundle morphology [MP:0004532] (68 genotypes, 102 annotations)
                                                                                        is-aabnormal inner hair cell kinocilium morphology +
                                                                                        is-aabnormal orientation of inner hair cell stereociliary bundles
                                                                                        is-aabsent inner hair cell stereocilia
                                                                                        is-adecreased inner hair cell stereocilia number
                                                                                        is-afused inner hair cell stereocilia
                                                                                        is-ashort inner hair cell stereocilia
                                                                                is-aabnormal inner hair cell synaptic ribbon morphology +
                                                                                is-acochlear inner hair cell degeneration

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last database update
10/08/2014
MGI 5.20
The Jackson Laboratory