| MP term: | abnormal outer hair cell stereociliary bundle morphology |
| Synonym: | abnormal OHC bundles |
| Synonym: | abnormal OHC stereocilia |
| Synonym: | abnormal OHC stereociliary bundles |
| MP id: | MP:0004527 |
| Definition: | any structural anomaly or disruption of the typical V or W-like pattern of arrangement of mechanosensitive hair bundles located at the apical end of cochlear OHCs; each hair bundle is normally composed of ~100 nonmotile, actin-filled microvilli (stereocilia) arranged in rows of increasing height and coupled to one another by morphologically distinct links: tip links, horizontal top connectors, shaft connectors, and ankle links; most hair bundles also possess a single motile kinocilium immediately adjacent to the tallest (outermost) row of stereocilia; a fifth link type, the kinocilial link, connects the kinocilium to its neighboring stereocilia |
| Number of paths to term: | 12 |
denotes an 'is-a' relationship
denotes a 'part-of' relationship
hearing/vestibular/ear phenotypeabnormal ear morphologyabnormal inner ear morphologyabnormal cochlea morphologyabnormal cochlear sensory epithelium morphologyabnormal cochlear hair cell morphologyabnormal cochlear hair cell stereociliary bundle morphologyabnormal cochlear hair cell inter-stereocilial links morphology +abnormal inner hair cell stereociliary bundle morphology +abnormal orientation of cochlear hair cell stereociliary bundles +abnormal outer hair cell stereociliary bundle morphology [MP:0004527] (103 genotypes, 143 annotations)abnormal orientation of outer hair cell stereociliary bundlesabnormal outer hair cell kinocilium morphologyabsent outer hair cell stereociliadecreased outer hair cell stereocilia numberfused outer hair cell stereociliashort outer hair cell stereociliaabsent cochlear hair cell stereociliadecreased cochlear hair cell stereocilia number +short cochlear hair cell stereocilia +thin cochlear hair cell stereociliahearing/vestibular/ear phenotypeabnormal ear morphologyabnormal inner ear morphologyabnormal cochlea morphologyabnormal cochlear sensory epithelium morphologyabnormal cochlear hair cell morphologyabnormal cochlear outer hair cell morphologyabnormal cochlear OHC afferent innervation patternabnormal cochlear OHC efferent innervation patternabnormal cochlear outer hair cell number +abnormal outer hair cell stereociliary bundle morphology [MP:0004527] (103 genotypes, 143 annotations)abnormal orientation of outer hair cell stereociliary bundlesabnormal outer hair cell kinocilium morphologyabsent outer hair cell stereociliadecreased outer hair cell stereocilia numberfused outer hair cell stereociliashort outer hair cell stereociliaabsent cochlear outer hair cellscochlear outer hair cell degenerationshort cochlear outer hair cellshearing/vestibular/ear phenotypeabnormal ear morphologyabnormal inner ear morphologyabnormal cochlea morphologyabnormal scala media morphologyabnormal organ of Corti morphologyabnormal cochlear hair cell morphologyabnormal cochlear hair cell stereociliary bundle morphologyabnormal cochlear hair cell inter-stereocilial links morphology +abnormal inner hair cell stereociliary bundle morphology +abnormal orientation of cochlear hair cell stereociliary bundles +abnormal outer hair cell stereociliary bundle morphology [MP:0004527] (103 genotypes, 143 annotations)abnormal orientation of outer hair cell stereociliary bundlesabnormal outer hair cell kinocilium morphologyabsent outer hair cell stereociliadecreased outer hair cell stereocilia numberfused outer hair cell stereociliashort outer hair cell stereociliaabsent cochlear hair cell stereociliadecreased cochlear hair cell stereocilia number +short cochlear hair cell stereocilia +thin cochlear hair cell stereociliahearing/vestibular/ear phenotypeabnormal ear morphologyabnormal inner ear morphologyabnormal cochlea morphologyabnormal scala media morphologyabnormal organ of Corti morphologyabnormal cochlear hair cell morphologyabnormal cochlear outer hair cell morphologyabnormal cochlear OHC afferent innervation patternabnormal cochlear OHC efferent innervation patternabnormal cochlear outer hair cell number +abnormal outer hair cell stereociliary bundle morphology [MP:0004527] (103 genotypes, 143 annotations)abnormal orientation of outer hair cell stereociliary bundlesabnormal outer hair cell kinocilium morphologyabsent outer hair cell stereociliadecreased outer hair cell stereocilia numberfused outer hair cell stereociliashort outer hair cell stereociliaabsent cochlear outer hair cellscochlear outer hair cell degenerationshort cochlear outer hair cellshearing/vestibular/ear phenotypeabnormal ear morphologyabnormal inner ear morphologyabnormal hair cell morphologyabnormal cochlear hair cell morphologyabnormal cochlear hair cell stereociliary bundle morphologyabnormal cochlear hair cell inter-stereocilial links morphology +abnormal inner hair cell stereociliary bundle morphology +abnormal orientation of cochlear hair cell stereociliary bundles +abnormal outer hair cell stereociliary bundle morphology [MP:0004527] (103 genotypes, 143 annotations)abnormal orientation of outer hair cell stereociliary bundlesabnormal outer hair cell kinocilium morphologyabsent outer hair cell stereociliadecreased outer hair cell stereocilia numberfused outer hair cell stereociliashort outer hair cell stereociliaabsent cochlear hair cell stereociliadecreased cochlear hair cell stereocilia number +short cochlear hair cell stereocilia +thin cochlear hair cell stereociliahearing/vestibular/ear phenotypeabnormal ear morphologyabnormal inner ear morphologyabnormal hair cell morphologyabnormal cochlear hair cell morphologyabnormal cochlear outer hair cell morphologyabnormal cochlear OHC afferent innervation patternabnormal cochlear OHC efferent innervation patternabnormal cochlear outer hair cell number +abnormal outer hair cell stereociliary bundle morphology [MP:0004527] (103 genotypes, 143 annotations)abnormal orientation of outer hair cell stereociliary bundlesabnormal outer hair cell kinocilium morphologyabsent outer hair cell stereociliadecreased outer hair cell stereocilia numberfused outer hair cell stereociliashort outer hair cell stereociliaabsent cochlear outer hair cellscochlear outer hair cell degenerationshort cochlear outer hair cellshearing/vestibular/ear phenotypeabnormal ear morphologyabnormal inner ear morphologyabnormal membranous labyrinth morphologyabnormal cochlear labyrinth morphologyabnormal scala media morphologyabnormal organ of Corti morphologyabnormal cochlear hair cell morphologyabnormal cochlear hair cell stereociliary bundle morphologyabnormal cochlear hair cell inter-stereocilial links morphology +abnormal inner hair cell stereociliary bundle morphology +abnormal orientation of cochlear hair cell stereociliary bundles +abnormal outer hair cell stereociliary bundle morphology [MP:0004527] (103 genotypes, 143 annotations)abnormal orientation of outer hair cell stereociliary bundlesabnormal outer hair cell kinocilium morphologyabsent outer hair cell stereociliadecreased outer hair cell stereocilia numberfused outer hair cell stereociliashort outer hair cell stereociliaabsent cochlear hair cell stereociliadecreased cochlear hair cell stereocilia number +short cochlear hair cell stereocilia +thin cochlear hair cell stereociliahearing/vestibular/ear phenotypeabnormal ear morphologyabnormal inner ear morphologyabnormal membranous labyrinth morphologyabnormal cochlear labyrinth morphologyabnormal scala media morphologyabnormal organ of Corti morphologyabnormal cochlear hair cell morphologyabnormal cochlear outer hair cell morphologyabnormal cochlear OHC afferent innervation patternabnormal cochlear OHC efferent innervation patternabnormal cochlear outer hair cell number +abnormal outer hair cell stereociliary bundle morphology [MP:0004527] (103 genotypes, 143 annotations)abnormal orientation of outer hair cell stereociliary bundlesabnormal outer hair cell kinocilium morphologyabsent outer hair cell stereociliadecreased outer hair cell stereocilia numberfused outer hair cell stereociliashort outer hair cell stereociliaabsent cochlear outer hair cellscochlear outer hair cell degenerationshort cochlear outer hair cellsnervous system phenotypeabnormal nervous system morphologyabnormal neuron morphologyabnormal sensory neuron morphologyabnormal mechanoreceptor morphologyabnormal hair cell morphologyabnormal cochlear hair cell morphologyabnormal cochlear hair cell stereociliary bundle morphologyabnormal cochlear hair cell inter-stereocilial links morphology +abnormal inner hair cell stereociliary bundle morphology +abnormal orientation of cochlear hair cell stereociliary bundles +abnormal outer hair cell stereociliary bundle morphology [MP:0004527] (103 genotypes, 143 annotations)abnormal orientation of outer hair cell stereociliary bundlesabnormal outer hair cell kinocilium morphologyabsent outer hair cell stereociliadecreased outer hair cell stereocilia numberfused outer hair cell stereociliashort outer hair cell stereociliaabsent cochlear hair cell stereociliadecreased cochlear hair cell stereocilia number +short cochlear hair cell stereocilia +thin cochlear hair cell stereocilianervous system phenotypeabnormal nervous system morphologyabnormal neuron morphologyabnormal sensory neuron morphologyabnormal mechanoreceptor morphologyabnormal hair cell morphologyabnormal cochlear hair cell morphologyabnormal cochlear outer hair cell morphologyabnormal cochlear OHC afferent innervation patternabnormal cochlear OHC efferent innervation patternabnormal cochlear outer hair cell number +abnormal outer hair cell stereociliary bundle morphology [MP:0004527] (103 genotypes, 143 annotations)abnormal orientation of outer hair cell stereociliary bundlesabnormal outer hair cell kinocilium morphologyabsent outer hair cell stereociliadecreased outer hair cell stereocilia numberfused outer hair cell stereociliashort outer hair cell stereociliaabsent cochlear outer hair cellscochlear outer hair cell degenerationshort cochlear outer hair cellsnervous system phenotypeabnormal nervous system morphologyabnormal somatic nervous system morphologyabnormal somatic sensory system morphologyabnormal sensory neuron morphologyabnormal mechanoreceptor morphologyabnormal hair cell morphologyabnormal cochlear hair cell morphologyabnormal cochlear hair cell stereociliary bundle morphologyabnormal cochlear hair cell inter-stereocilial links morphology +abnormal inner hair cell stereociliary bundle morphology +abnormal orientation of cochlear hair cell stereociliary bundles +abnormal outer hair cell stereociliary bundle morphology [MP:0004527] (103 genotypes, 143 annotations)abnormal orientation of outer hair cell stereociliary bundlesabnormal outer hair cell kinocilium morphologyabsent outer hair cell stereociliadecreased outer hair cell stereocilia numberfused outer hair cell stereociliashort outer hair cell stereociliaabsent cochlear hair cell stereociliadecreased cochlear hair cell stereocilia number +short cochlear hair cell stereocilia +thin cochlear hair cell stereocilianervous system phenotypeabnormal nervous system morphologyabnormal somatic nervous system morphologyabnormal somatic sensory system morphologyabnormal sensory neuron morphologyabnormal mechanoreceptor morphologyabnormal hair cell morphologyabnormal cochlear hair cell morphologyabnormal cochlear outer hair cell morphologyabnormal cochlear OHC afferent innervation patternabnormal cochlear OHC efferent innervation patternabnormal cochlear outer hair cell number +abnormal outer hair cell stereociliary bundle morphology [MP:0004527] (103 genotypes, 143 annotations)abnormal orientation of outer hair cell stereociliary bundlesabnormal outer hair cell kinocilium morphologyabsent outer hair cell stereociliadecreased outer hair cell stereocilia numberfused outer hair cell stereociliashort outer hair cell stereociliaabsent cochlear outer hair cellscochlear outer hair cell degenerationshort cochlear outer hair cellsMouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc |
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last database update 05/08/2013 MGI 5.13 |
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