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Mammalian Phenotype Browser
Term Detail
MP term:abnormal B cell physiology
Synonym: B cell dysfunction
Synonym: B-cell dysfunction
Synonym: B lymphocyte dysfunction
Synonym: B lymphocyte functional anomalies
MP id: MP:0002459
Definition: any functional anomaly of lymphocytes that expresses membrane-bound antibody, and differentiate into antibody-secreting plasma cells and memory cells upon interaction with antigen; B cells are the primary lymphocyte responsible for humoral immunity, and are most effective against extracellular pathogens
Number of paths to term: 7

is-adenotes an 'is-a' relationship
part-ofdenotes a 'part-of' relationship


mammalian phenotype
        is-ahematopoietic system phenotype
                is-aabnormal hematopoietic system physiology
                        is-aabnormal blood cell physiology
                                is-aabnormal leukocyte physiology
                                        is-aabnormal lymphocyte physiology
                                                is-aabnormal B cell physiology [MP:0002459] (1530 genotypes, 3501 annotations)
                                                        is-aabnormal B cell activation +
                                                        is-aabnormal B cell apoptosis +
                                                        is-aabnormal B lymphocyte antigen presentation +
                                                        is-aabnormal class switch recombination
                                                        is-aabnormal follicular B cell physiology
                                                        is-aabnormal germinal center B cell physiology
                                                        is-aabnormal immunoglobulin level +
                                                        is-aabnormal marginal zone B cell physiology
                                                        is-aabnormal memory B cell physiology
                                                is-aabnormal lymphocyte activation involved in immune response +
                                                is-aabnormal NK cell physiology +
                                                is-aabnormal T cell physiology +


mammalian phenotype
        is-aimmune system phenotype
                is-aabnormal immune system physiology
                        is-aabnormal adaptive immunity
                                is-aabnormal leukocyte physiology
                                        is-aabnormal lymphocyte physiology
                                                is-aabnormal B cell physiology [MP:0002459] (1530 genotypes, 3501 annotations)
                                                        is-aabnormal B cell activation +
                                                        is-aabnormal B cell apoptosis +
                                                        is-aabnormal B lymphocyte antigen presentation +
                                                        is-aabnormal class switch recombination
                                                        is-aabnormal follicular B cell physiology
                                                        is-aabnormal germinal center B cell physiology
                                                        is-aabnormal immunoglobulin level +
                                                        is-aabnormal marginal zone B cell physiology
                                                        is-aabnormal memory B cell physiology
                                                is-aabnormal lymphocyte activation involved in immune response +
                                                is-aabnormal NK cell physiology +
                                                is-aabnormal T cell physiology +


mammalian phenotype
        is-aimmune system phenotype
                is-aabnormal immune system physiology
                        is-aabnormal adaptive immunity
                                is-aabnormal professional antigen presenting cell physiology
                                        is-aabnormal B cell physiology [MP:0002459] (1530 genotypes, 3501 annotations)
                                                is-aabnormal B cell activation +
                                                is-aabnormal B cell apoptosis +
                                                is-aabnormal B lymphocyte antigen presentation +
                                                is-aabnormal class switch recombination
                                                is-aabnormal follicular B cell physiology
                                                is-aabnormal germinal center B cell physiology
                                                is-aabnormal immunoglobulin level +
                                                is-aabnormal marginal zone B cell physiology
                                                is-aabnormal memory B cell physiology
                                        is-aabnormal dendritic cell physiology +
                                        is-aabnormal macrophage physiology +


mammalian phenotype
        is-aimmune system phenotype
                is-aabnormal immune system physiology
                        is-aabnormal cell-mediated immunity
                                is-aabnormal leukocyte physiology
                                        is-aabnormal lymphocyte physiology
                                                is-aabnormal B cell physiology [MP:0002459] (1530 genotypes, 3501 annotations)
                                                        is-aabnormal B cell activation +
                                                        is-aabnormal B cell apoptosis +
                                                        is-aabnormal B lymphocyte antigen presentation +
                                                        is-aabnormal class switch recombination
                                                        is-aabnormal follicular B cell physiology
                                                        is-aabnormal germinal center B cell physiology
                                                        is-aabnormal immunoglobulin level +
                                                        is-aabnormal marginal zone B cell physiology
                                                        is-aabnormal memory B cell physiology
                                                is-aabnormal lymphocyte activation involved in immune response +
                                                is-aabnormal NK cell physiology +
                                                is-aabnormal T cell physiology +


mammalian phenotype
        is-aimmune system phenotype
                is-aabnormal immune system physiology
                        is-aabnormal cell-mediated immunity
                                is-aabnormal professional antigen presenting cell physiology
                                        is-aabnormal B cell physiology [MP:0002459] (1530 genotypes, 3501 annotations)
                                                is-aabnormal B cell activation +
                                                is-aabnormal B cell apoptosis +
                                                is-aabnormal B lymphocyte antigen presentation +
                                                is-aabnormal class switch recombination
                                                is-aabnormal follicular B cell physiology
                                                is-aabnormal germinal center B cell physiology
                                                is-aabnormal immunoglobulin level +
                                                is-aabnormal marginal zone B cell physiology
                                                is-aabnormal memory B cell physiology
                                        is-aabnormal dendritic cell physiology +
                                        is-aabnormal macrophage physiology +


mammalian phenotype
        is-aimmune system phenotype
                is-aabnormal immune system physiology
                        is-aabnormal immune cell physiology
                                is-aabnormal leukocyte physiology
                                        is-aabnormal lymphocyte physiology
                                                is-aabnormal B cell physiology [MP:0002459] (1530 genotypes, 3501 annotations)
                                                        is-aabnormal B cell activation +
                                                        is-aabnormal B cell apoptosis +
                                                        is-aabnormal B lymphocyte antigen presentation +
                                                        is-aabnormal class switch recombination
                                                        is-aabnormal follicular B cell physiology
                                                        is-aabnormal germinal center B cell physiology
                                                        is-aabnormal immunoglobulin level +
                                                        is-aabnormal marginal zone B cell physiology
                                                        is-aabnormal memory B cell physiology
                                                is-aabnormal lymphocyte activation involved in immune response +
                                                is-aabnormal NK cell physiology +
                                                is-aabnormal T cell physiology +


mammalian phenotype
        is-aimmune system phenotype
                is-aabnormal immune system physiology
                        is-aabnormal immune cell physiology
                                is-aabnormal professional antigen presenting cell physiology
                                        is-aabnormal B cell physiology [MP:0002459] (1530 genotypes, 3501 annotations)
                                                is-aabnormal B cell activation +
                                                is-aabnormal B cell apoptosis +
                                                is-aabnormal B lymphocyte antigen presentation +
                                                is-aabnormal class switch recombination
                                                is-aabnormal follicular B cell physiology
                                                is-aabnormal germinal center B cell physiology
                                                is-aabnormal immunoglobulin level +
                                                is-aabnormal marginal zone B cell physiology
                                                is-aabnormal memory B cell physiology
                                        is-aabnormal dendritic cell physiology +
                                        is-aabnormal macrophage physiology +

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last database update
09/23/2014
MGI 5.19
The Jackson Laboratory