| MP term: | abnormal B cell physiology |
| Synonym: | B cell dysfunction |
| Synonym: | B-cell dysfunction |
| Synonym: | B lymphocyte dysfunction |
| Synonym: | B lymphocyte functional anomalies |
| MP id: | MP:0002459 |
| Definition: | any functional anomaly of lymphocytes that expresses membrane-bound antibody, and differentiate into antibody-secreting plasma cells and memory cells upon interaction with antigen; B cells are the primary lymphocyte responsible for humoral immunity, and are most effective against extracellular pathogens |
| Number of paths to term: | 6 |
denotes an 'is-a' relationship
denotes a 'part-of' relationship
immune system phenotypeabnormal immune system physiologyabnormal adaptive immunityabnormal leukocyte physiologyabnormal lymphocyte physiologyabnormal B cell physiology [MP:0002459] (1415 genotypes, 3207 annotations)abnormal B cell activation +abnormal B cell apoptosis +abnormal B lymphocyte antigen presentation +abnormal class switch recombinationabnormal follicular B cell physiologyabnormal germinal center B cell physiologyabnormal immunoglobulin level +abnormal marginal zone B cell physiologyabnormal memory B cell physiologyabnormal B lymphocyte antigen presentation +abnormal NK cell physiology +abnormal T cell physiology +immune system phenotypeabnormal immune system physiologyabnormal adaptive immunityabnormal professional antigen presenting cell physiologyabnormal B cell physiology [MP:0002459] (1415 genotypes, 3207 annotations)abnormal B cell activation +abnormal B cell apoptosis +abnormal B lymphocyte antigen presentation +abnormal class switch recombinationabnormal follicular B cell physiologyabnormal germinal center B cell physiologyabnormal immunoglobulin level +abnormal marginal zone B cell physiologyabnormal memory B cell physiologyabnormal dendritic cell physiology +abnormal macrophage physiology +immune system phenotypeabnormal immune system physiologyabnormal cell-mediated immunityabnormal leukocyte physiologyabnormal lymphocyte physiologyabnormal B cell physiology [MP:0002459] (1415 genotypes, 3207 annotations)abnormal B cell activation +abnormal B cell apoptosis +abnormal B lymphocyte antigen presentation +abnormal class switch recombinationabnormal follicular B cell physiologyabnormal germinal center B cell physiologyabnormal immunoglobulin level +abnormal marginal zone B cell physiologyabnormal memory B cell physiologyabnormal B lymphocyte antigen presentation +abnormal NK cell physiology +abnormal T cell physiology +immune system phenotypeabnormal immune system physiologyabnormal cell-mediated immunityabnormal professional antigen presenting cell physiologyabnormal B cell physiology [MP:0002459] (1415 genotypes, 3207 annotations)abnormal B cell activation +abnormal B cell apoptosis +abnormal B lymphocyte antigen presentation +abnormal class switch recombinationabnormal follicular B cell physiologyabnormal germinal center B cell physiologyabnormal immunoglobulin level +abnormal marginal zone B cell physiologyabnormal memory B cell physiologyabnormal dendritic cell physiology +abnormal macrophage physiology +immune system phenotypeabnormal immune system physiologyabnormal immune cell physiologyabnormal leukocyte physiologyabnormal lymphocyte physiologyabnormal B cell physiology [MP:0002459] (1415 genotypes, 3207 annotations)abnormal B cell activation +abnormal B cell apoptosis +abnormal B lymphocyte antigen presentation +abnormal class switch recombinationabnormal follicular B cell physiologyabnormal germinal center B cell physiologyabnormal immunoglobulin level +abnormal marginal zone B cell physiologyabnormal memory B cell physiologyabnormal B lymphocyte antigen presentation +abnormal NK cell physiology +abnormal T cell physiology +immune system phenotypeabnormal immune system physiologyabnormal immune cell physiologyabnormal professional antigen presenting cell physiologyabnormal B cell physiology [MP:0002459] (1415 genotypes, 3207 annotations)abnormal B cell activation +abnormal B cell apoptosis +abnormal B lymphocyte antigen presentation +abnormal class switch recombinationabnormal follicular B cell physiologyabnormal germinal center B cell physiologyabnormal immunoglobulin level +abnormal marginal zone B cell physiologyabnormal memory B cell physiologyabnormal dendritic cell physiology +abnormal macrophage physiology +Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc |
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last database update 05/08/2013 MGI 5.13 |
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