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Mammalian Phenotype Browser
Term Detail
MP term:abnormal macrophage physiology
Synonym: macrophage dysfunction
MP id: MP:0002451
Definition: any functional anomaly of the large mononuclear phagocytes which differentiate from monocytes, are typically resident in a particular tissue, and capable of phagocytosing a variety of extracellular particulate material, including immune complexes, microorganisms, and dead cells
Number of paths to term: 8

is-adenotes an 'is-a' relationship
part-ofdenotes a 'part-of' relationship


mammalian phenotype
        is-ahematopoietic system phenotype
                is-aabnormal hematopoietic system physiology
                        is-aabnormal blood cell physiology
                                is-aabnormal leukocyte physiology
                                        is-aabnormal granulocyte physiology +
                                        is-aabnormal leukocyte migration +
                                        is-aabnormal lymphocyte physiology +
                                        is-aabnormal macrophage physiology [MP:0002451] (603 genotypes, 690 annotations)
                                                is-aabnormal macrophage activation involved in immune response
                                                is-aabnormal macrophage antigen presentation +
                                                is-aabnormal macrophage apoptosis +
                                                is-aabnormal macrophage chemotaxis +
                                                is-aabnormal macrophage cytokine production +
                                                is-aabnormal macrophage nitric oxide production +
                                                is-aabnormal macrophage proliferation +
                                                is-aabnormal microglial cell physiology +
                                                is-aabnormal osteoclast physiology
                                                is-aimpaired macrophage phagocytosis
                                        is-aleukostasis


mammalian phenotype
        is-aimmune system phenotype
                is-aabnormal immune system physiology
                        is-aabnormal adaptive immunity
                                is-aabnormal leukocyte physiology
                                        is-aabnormal granulocyte physiology +
                                        is-aabnormal leukocyte migration +
                                        is-aabnormal lymphocyte physiology +
                                        is-aabnormal macrophage physiology [MP:0002451] (603 genotypes, 690 annotations)
                                                is-aabnormal macrophage activation involved in immune response
                                                is-aabnormal macrophage antigen presentation +
                                                is-aabnormal macrophage apoptosis +
                                                is-aabnormal macrophage chemotaxis +
                                                is-aabnormal macrophage cytokine production +
                                                is-aabnormal macrophage nitric oxide production +
                                                is-aabnormal macrophage proliferation +
                                                is-aabnormal microglial cell physiology +
                                                is-aabnormal osteoclast physiology
                                                is-aimpaired macrophage phagocytosis
                                        is-aleukostasis


mammalian phenotype
        is-aimmune system phenotype
                is-aabnormal immune system physiology
                        is-aabnormal adaptive immunity
                                is-aabnormal professional antigen presenting cell physiology
                                        is-aabnormal B cell physiology +
                                        is-aabnormal dendritic cell physiology +
                                        is-aabnormal macrophage physiology [MP:0002451] (603 genotypes, 690 annotations)
                                                is-aabnormal macrophage activation involved in immune response
                                                is-aabnormal macrophage antigen presentation +
                                                is-aabnormal macrophage apoptosis +
                                                is-aabnormal macrophage chemotaxis +
                                                is-aabnormal macrophage cytokine production +
                                                is-aabnormal macrophage nitric oxide production +
                                                is-aabnormal macrophage proliferation +
                                                is-aabnormal microglial cell physiology +
                                                is-aabnormal osteoclast physiology
                                                is-aimpaired macrophage phagocytosis


mammalian phenotype
        is-aimmune system phenotype
                is-aabnormal immune system physiology
                        is-aabnormal cell-mediated immunity
                                is-aabnormal leukocyte physiology
                                        is-aabnormal granulocyte physiology +
                                        is-aabnormal leukocyte migration +
                                        is-aabnormal lymphocyte physiology +
                                        is-aabnormal macrophage physiology [MP:0002451] (603 genotypes, 690 annotations)
                                                is-aabnormal macrophage activation involved in immune response
                                                is-aabnormal macrophage antigen presentation +
                                                is-aabnormal macrophage apoptosis +
                                                is-aabnormal macrophage chemotaxis +
                                                is-aabnormal macrophage cytokine production +
                                                is-aabnormal macrophage nitric oxide production +
                                                is-aabnormal macrophage proliferation +
                                                is-aabnormal microglial cell physiology +
                                                is-aabnormal osteoclast physiology
                                                is-aimpaired macrophage phagocytosis
                                        is-aleukostasis


mammalian phenotype
        is-aimmune system phenotype
                is-aabnormal immune system physiology
                        is-aabnormal cell-mediated immunity
                                is-aabnormal professional antigen presenting cell physiology
                                        is-aabnormal B cell physiology +
                                        is-aabnormal dendritic cell physiology +
                                        is-aabnormal macrophage physiology [MP:0002451] (603 genotypes, 690 annotations)
                                                is-aabnormal macrophage activation involved in immune response
                                                is-aabnormal macrophage antigen presentation +
                                                is-aabnormal macrophage apoptosis +
                                                is-aabnormal macrophage chemotaxis +
                                                is-aabnormal macrophage cytokine production +
                                                is-aabnormal macrophage nitric oxide production +
                                                is-aabnormal macrophage proliferation +
                                                is-aabnormal microglial cell physiology +
                                                is-aabnormal osteoclast physiology
                                                is-aimpaired macrophage phagocytosis


mammalian phenotype
        is-aimmune system phenotype
                is-aabnormal immune system physiology
                        is-aabnormal immune cell physiology
                                is-aabnormal leukocyte physiology
                                        is-aabnormal granulocyte physiology +
                                        is-aabnormal leukocyte migration +
                                        is-aabnormal lymphocyte physiology +
                                        is-aabnormal macrophage physiology [MP:0002451] (603 genotypes, 690 annotations)
                                                is-aabnormal macrophage activation involved in immune response
                                                is-aabnormal macrophage antigen presentation +
                                                is-aabnormal macrophage apoptosis +
                                                is-aabnormal macrophage chemotaxis +
                                                is-aabnormal macrophage cytokine production +
                                                is-aabnormal macrophage nitric oxide production +
                                                is-aabnormal macrophage proliferation +
                                                is-aabnormal microglial cell physiology +
                                                is-aabnormal osteoclast physiology
                                                is-aimpaired macrophage phagocytosis
                                        is-aleukostasis


mammalian phenotype
        is-aimmune system phenotype
                is-aabnormal immune system physiology
                        is-aabnormal immune cell physiology
                                is-aabnormal professional antigen presenting cell physiology
                                        is-aabnormal B cell physiology +
                                        is-aabnormal dendritic cell physiology +
                                        is-aabnormal macrophage physiology [MP:0002451] (603 genotypes, 690 annotations)
                                                is-aabnormal macrophage activation involved in immune response
                                                is-aabnormal macrophage antigen presentation +
                                                is-aabnormal macrophage apoptosis +
                                                is-aabnormal macrophage chemotaxis +
                                                is-aabnormal macrophage cytokine production +
                                                is-aabnormal macrophage nitric oxide production +
                                                is-aabnormal macrophage proliferation +
                                                is-aabnormal microglial cell physiology +
                                                is-aabnormal osteoclast physiology
                                                is-aimpaired macrophage phagocytosis


mammalian phenotype
        is-aimmune system phenotype
                is-aabnormal immune system physiology
                        is-aabnormal innate immunity
                                is-aabnormal acute phase protein level +
                                is-aabnormal complement pathway +
                                is-aabnormal macrophage physiology [MP:0002451] (603 genotypes, 690 annotations)
                                        is-aabnormal macrophage activation involved in immune response
                                        is-aabnormal macrophage antigen presentation +
                                        is-aabnormal macrophage apoptosis +
                                        is-aabnormal macrophage chemotaxis +
                                        is-aabnormal macrophage cytokine production +
                                        is-aabnormal macrophage nitric oxide production +
                                        is-aabnormal macrophage proliferation +
                                        is-aabnormal microglial cell physiology +
                                        is-aabnormal osteoclast physiology
                                        is-aimpaired macrophage phagocytosis
                                is-aabnormal neutrophil physiology +
                                is-aabnormal NK cell physiology +

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/26/2014
MGI 5.19
The Jackson Laboratory