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Mammalian Phenotype Browser
Term Detail
MP term:abnormal type II pneumocyte morphology
Synonym: abnormal AT2 morphology
Synonym: abnormal ATII morphology
Synonym: abnormal Cuboidal type II cell morphology
Synonym: abnormal granular pneumocytes morphology
Synonym: abnormal Great alveolar cells morphology
Synonym: abnormal Lung type 2 cells morphology
Synonym: abnormal Lung type II cells morphology
Synonym: abnormal TII morphology
Synonym: abnormal type 2 alveolar epithelial cells morphology
Synonym: abnormal type 2 alveolocytes morphology
Synonym: abnormal type 2 pneumocyte morphology
Synonym: abnormal type II alveolar epithelial cells morphology
Synonym: abnormal type II alveolocytes morphology
Synonym: abnormal type II cells morphology
Synonym: abnormal type II pneumocytes morphology
Synonym: abnormal type II pneumonocytes morphology
MP id: MP:0002275
Definition: any structural anomaly of the granular and roughly cuboidal cells typically found at the alveolar-septal junction that modulate the fluid surrounding the alveolar epithelium by secreting and recycling surfactants, and also contribute to tissue repair and can differentiate after injury into a type I pneumocyte; type II cells cover a much smaller surface area than type I cells (less than 5 percent), but are much more numerous and contain lamellar bodies on the apical surface where surfactant is stored
Number of paths to term: 4

is-adenotes an 'is-a' relationship
part-ofdenotes a 'part-of' relationship


mammalian phenotype
        is-arespiratory system phenotype
                is-aabnormal respiratory system morphology
                        is-aabnormal lung morphology
                                is-aabnormal lung epithelium morphology
                                        is-aabnormal pulmonary alveolus epithelium morphology
                                                is-aabnormal pulmonary alveolus epithelial cell morphology
                                                        is-aabnormal type I pneumocyte morphology +
                                                        is-aabnormal type II pneumocyte morphology [MP:0002275] (76 genotypes, 122 annotations)
                                                                is-aabnormal alveolar lamellar body morphology +
                                                                is-adecreased type II pneumocyte number +
                                                                is-aincreased type II pneumocyte number


mammalian phenotype
        is-arespiratory system phenotype
                is-aabnormal respiratory system morphology
                        is-aabnormal lung morphology
                                is-aabnormal pulmonary alveolar system morphology
                                        is-aabnormal pulmonary acinus morphology
                                                is-aabnormal pulmonary alveolus morphology
                                                        is-aabnormal pulmonary alveolus epithelium morphology
                                                                is-aabnormal pulmonary alveolus epithelial cell morphology
                                                                        is-aabnormal type I pneumocyte morphology +
                                                                        is-aabnormal type II pneumocyte morphology [MP:0002275] (76 genotypes, 122 annotations)
                                                                                is-aabnormal alveolar lamellar body morphology +
                                                                                is-adecreased type II pneumocyte number +
                                                                                is-aincreased type II pneumocyte number


mammalian phenotype
        is-arespiratory system phenotype
                is-aabnormal respiratory system morphology
                        is-aabnormal lung morphology
                                is-aabnormal pulmonary alveolar system morphology
                                        is-aabnormal pulmonary alveolar parenchyma morphology
                                                is-aabnormal pulmonary alveolus epithelial cell morphology
                                                        is-aabnormal type I pneumocyte morphology +
                                                        is-aabnormal type II pneumocyte morphology [MP:0002275] (76 genotypes, 122 annotations)
                                                                is-aabnormal alveolar lamellar body morphology +
                                                                is-adecreased type II pneumocyte number +
                                                                is-aincreased type II pneumocyte number


mammalian phenotype
        is-arespiratory system phenotype
                is-aabnormal respiratory system morphology
                        is-aabnormal respiratory epithelium morphology
                                is-aabnormal lung epithelium morphology
                                        is-aabnormal pulmonary alveolus epithelium morphology
                                                is-aabnormal pulmonary alveolus epithelial cell morphology
                                                        is-aabnormal type I pneumocyte morphology +
                                                        is-aabnormal type II pneumocyte morphology [MP:0002275] (76 genotypes, 122 annotations)
                                                                is-aabnormal alveolar lamellar body morphology +
                                                                is-adecreased type II pneumocyte number +
                                                                is-aincreased type II pneumocyte number

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last database update
04/08/2014
MGI 5.17
The Jackson Laboratory