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Mammalian Phenotype Browser
Term Detail
MP term:anencephaly
Synonym: anencephalia
MP id: MP:0001890
Alternate id: MP:0000915, Fyler:4332
Definition: anomaly that occurs when the anterior neuropore of the neural tube fails to close, resulting in the congenital partial or complete absence of the cranial vault accompanied by absence of overlying tissues, including the brain and cerebral hemispheres, skull and scalp; in affected organisms, the forebrain remains in contact with the amniotic fluid and subsequently degenerates, including the cerebrum (areas responsible for cognition); any remaining brain tissue, such as the brain stem, is often exposed
Number of paths to term: 1

is-adenotes an 'is-a' relationship
part-ofdenotes a 'part-of' relationship

mammalian phenotype
        is-anervous system phenotype
                is-aabnormal nervous system morphology
                        is-aabnormal nervous system development
                                is-aabnormal brain development +
                                is-aabnormal CNS synapse formation +
                                is-aabnormal embryonic/fetal subventricular zone morphology +
                                is-aabnormal neural plate morphology +
                                is-aabnormal neural tube morphology +
                                is-aabnormal neuron differentiation +
                                is-aabnormal neuronal stem cell morphology
                                is-aabnormal vestibulocochlear ganglion morphology +
                                is-aanencephaly [MP:0001890] (30 genotypes, 30 annotations)

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MGI 6.08
The Jackson Laboratory