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Mammalian Phenotype Browser
Term Detail
MP term:abnormal humoral immune response
Synonym: antibody-mediated immune response abnormalities
Synonym: humoral immune response dysfunction
MP id: MP:0001800
Definition: any functional anomaly of the aspect of immunity that is mediated by secreted antibodies produced in the cells of the B lymphocyte lineage (B cell) and the accessory processes that accompany it, including Th2 activation and cytokine production, germinal center formation and isotype switching, affinity maturation and memory cell generation; it also refers to the effector functions of antibody, which include pathogen and toxin neutralization, classical complement activation, and opsonin promotion of phagocytosis and pathogen elimination
Number of paths to term: 1

is-adenotes an 'is-a' relationship
part-ofdenotes a 'part-of' relationship


mammalian phenotype
        is-aimmune system phenotype
                is-aabnormal immune system physiology
                        is-aabnormal adaptive immunity +
                        is-aabnormal antigen presentation +
                        is-aabnormal cell-mediated immunity +
                        is-aabnormal humoral immune response [MP:0001800] (1204 genotypes, 2709 annotations)
                                is-aabnormal complement pathway +
                                is-aabnormal immunoglobulin level +
                        is-aabnormal hypersensitivity reaction +
                        is-aabnormal immune cell physiology +
                        is-aabnormal immune organ physiology +
                        is-aabnormal immune serum protein physiology +
                        is-aabnormal immune tolerance +
                        is-aabnormal immunoglobulin transcytosis
                        is-aabnormal inflammatory response +
                        is-aabnormal innate immunity +
                        is-aabnormal lymphatic system physiology +
                        is-aabnormal response to infection +
                        is-aabnormal response to transplant +

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last database update
04/08/2014
MGI 5.17
The Jackson Laboratory