| MP term: | abnormal humoral immune response |
| Synonym: | antibody-mediated immune response abnormalities |
| Synonym: | humoral immune response dysfunction |
| MP id: | MP:0001800 |
| Definition: | any functional anomaly of the aspect of immunity that is mediated by secreted antibodies produced in the cells of the B lymphocyte lineage (B cell) and the accessory processes that accompany it, including Th2 activation and cytokine production, germinal center formation and isotype switching, affinity maturation and memory cell generation; it also refers to the effector functions of antibody, which include pathogen and toxin neutralization, classical complement activation, and opsonin promotion of phagocytosis and pathogen elimination |
| Number of paths to term: | 1 |
denotes an 'is-a' relationship
denotes a 'part-of' relationship
immune system phenotypeabnormal immune system physiologyabnormal adaptive immunity +abnormal antigen presentation +abnormal cell-mediated immunity +abnormal humoral immune response [MP:0001800] (1155 genotypes, 2571 annotations)abnormal complement pathway +abnormal immunoglobulin level +abnormal hypersensitivity reaction +abnormal immune cell physiology +abnormal immune organ physiology +abnormal immune serum protein physiology +abnormal immune tolerance +abnormal immunoglobulin transcytosisabnormal inflammatory response +abnormal innate immunity +abnormal lymphatic system physiology +abnormal response to infection +abnormal response to transplant +Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc |
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last database update 06/05/2013 MGI 5.13 |
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