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Mammalian Phenotype Browser
Term Detail
MP term:abnormal megakaryocyte differentiation
Synonym: abnormal megacaryocyte differentiation
Synonym: abnormal megalocaryocyte differentiation
Synonym: abnormal megalokaryocyte differentiation
MP id: MP:0000229
Alternate id: MP:0001593
Definition: atypical production of or inability to produce of a giant cell 50 to 100 micron in diameter, with a greatly lobulated nucleus, found in the bone marrow; mature blood platelets are released from its cytoplasm
Number of paths to term: 2

is-adenotes an 'is-a' relationship
part-ofdenotes a 'part-of' relationship

mammalian phenotype
        is-acellular phenotype
                is-aabnormal cell physiology
                        is-aabnormal cell differentiation
                                is-aabnormal airway basal cell differentiation
                                is-aabnormal Bergmann glial cell differentiation
                                is-aabnormal dendritic cell differentiation +
                                is-aabnormal enterocyte differentiation
                                is-aabnormal fat cell differentiation +
                                is-aabnormal granulocyte differentiation +
                                is-aabnormal keratinocyte differentiation +
                                is-aabnormal megakaryocyte differentiation [MP:0000229] (45 genotypes, 45 annotations)
                                is-aabnormal mesenchymal cell differentiation involved in lung development
                                is-aabnormal mononuclear cell differentiation +
                                is-aabnormal myoblast differentiation
                                is-aabnormal myofibroblast differentiation +
                                is-aabnormal neuron differentiation +
                                is-aabnormal organ of Corti supporting cell differentiation +
                                is-aabnormal osteoblast differentiation +
                                is-aabnormal osteoclast differentiation
                                is-aabnormal pancreatic alpha cell differentiation
                                is-aabnormal pancreatic beta cell differentiation
                                is-aabnormal pancreatic delta cell differentiation
                                is-aabnormal pancreatic epsilon cell differentiation
                                is-aabnormal PP cell differentiation
                                is-aabnormal vascular endothelial cell differentiation
                                is-aimpaired granulosa cell differentiation +
                                is-aimpaired luteal cell differentiation
                                is-aimpaired neural crest cell differentiation +

mammalian phenotype
        is-ahematopoietic system phenotype
                is-aabnormal hematopoietic system morphology/development
                        is-aabnormal bone marrow cell morphology/development
                                is-aabnormal megakaryocyte progenitor cell morphology
                                        is-aabnormal megakaryocyte morphology
                                                is-aabnormal megakaryocyte differentiation [MP:0000229] (45 genotypes, 45 annotations)
                                                is-aabnormal thrombopoiesis +
                                                is-adecreased megakaryocyte cell number +
                                                is-aincreased megakaryocyte cell number

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 5.21
The Jackson Laboratory