| MP term: | abnormal microglial cell morphology |
| MP id: | MP:0000136 |
| Definition: | any structural anomaly of the small, migratory, phagocytic, interstitial cells derived from myeloid progenitor cells and found in the parenchyma of the central nervous system; microglia are scavengers, engulfing dead cells and other debris, and in Alzheimer's disease, microglia are found associated with dying nerve cells and amyloid plaques |
| Number of paths to term: | 8 |
denotes an 'is-a' relationship
denotes a 'part-of' relationship
hematopoietic system phenotypeabnormal hematopoietic system morphology/developmentabnormal blood cell morphology/developmentabnormal hematopoiesisabnormal leukocyte morphologyabnormal mononuclear cell morphologyabnormal mononuclear phagocyte morphologyabnormal macrophage morphologyabnormal alveolar macrophage morphologyabnormal Kupffer cell morphologyabnormal macrophage derived foam cell morphology +abnormal macrophage differentiationabnormal metallophilic macrophage morphologyabnormal microglial cell morphology [MP:0000136] (134 genotypes, 136 annotations)abnormal microglial cell differentiationdecreased microglial cell numbermicrogliosisabnormal osteoclast morphology +abnormal peritoneal macrophage morphologyabnormal perivascular macrophage morphologyabnormal spleen marginal zone macrophage morphologydecreased macrophage cell number +increased macrophage cell number +hematopoietic system phenotypeabnormal hematopoietic system morphology/developmentabnormal blood cell morphology/developmentabnormal hematopoiesisabnormal leukocyte morphologyabnormal myeloid leukocyte morphologyabnormal phagocyte morphologyabnormal mononuclear phagocyte morphologyabnormal macrophage morphologyabnormal alveolar macrophage morphologyabnormal Kupffer cell morphologyabnormal macrophage derived foam cell morphology +abnormal macrophage differentiationabnormal metallophilic macrophage morphologyabnormal microglial cell morphology [MP:0000136] (134 genotypes, 136 annotations)abnormal microglial cell differentiationdecreased microglial cell numbermicrogliosisabnormal osteoclast morphology +abnormal peritoneal macrophage morphologyabnormal perivascular macrophage morphologyabnormal spleen marginal zone macrophage morphologydecreased macrophage cell number +increased macrophage cell number +hematopoietic system phenotypeabnormal hematopoietic system morphology/developmentabnormal blood cell morphology/developmentabnormal leukocyte morphologyabnormal mononuclear cell morphologyabnormal mononuclear phagocyte morphologyabnormal macrophage morphologyabnormal alveolar macrophage morphologyabnormal Kupffer cell morphologyabnormal macrophage derived foam cell morphology +abnormal macrophage differentiationabnormal metallophilic macrophage morphologyabnormal microglial cell morphology [MP:0000136] (134 genotypes, 136 annotations)abnormal microglial cell differentiationdecreased microglial cell numbermicrogliosisabnormal osteoclast morphology +abnormal peritoneal macrophage morphologyabnormal perivascular macrophage morphologyabnormal spleen marginal zone macrophage morphologydecreased macrophage cell number +increased macrophage cell number +hematopoietic system phenotypeabnormal hematopoietic system morphology/developmentabnormal blood cell morphology/developmentabnormal leukocyte morphologyabnormal myeloid leukocyte morphologyabnormal phagocyte morphologyabnormal mononuclear phagocyte morphologyabnormal macrophage morphologyabnormal alveolar macrophage morphologyabnormal Kupffer cell morphologyabnormal macrophage derived foam cell morphology +abnormal macrophage differentiationabnormal metallophilic macrophage morphologyabnormal microglial cell morphology [MP:0000136] (134 genotypes, 136 annotations)abnormal microglial cell differentiationdecreased microglial cell numbermicrogliosisabnormal osteoclast morphology +abnormal peritoneal macrophage morphologyabnormal perivascular macrophage morphologyabnormal spleen marginal zone macrophage morphologydecreased macrophage cell number +increased macrophage cell number +immune system phenotypeabnormal immune system morphologyabnormal immune system cell morphologyabnormal leukocyte morphologyabnormal mononuclear cell morphologyabnormal mononuclear phagocyte morphologyabnormal macrophage morphologyabnormal alveolar macrophage morphologyabnormal Kupffer cell morphologyabnormal macrophage derived foam cell morphology +abnormal macrophage differentiationabnormal metallophilic macrophage morphologyabnormal microglial cell morphology [MP:0000136] (134 genotypes, 136 annotations)abnormal microglial cell differentiationdecreased microglial cell numbermicrogliosisabnormal osteoclast morphology +abnormal peritoneal macrophage morphologyabnormal perivascular macrophage morphologyabnormal spleen marginal zone macrophage morphologydecreased macrophage cell number +increased macrophage cell number +immune system phenotypeabnormal immune system morphologyabnormal immune system cell morphologyabnormal leukocyte morphologyabnormal myeloid leukocyte morphologyabnormal phagocyte morphologyabnormal mononuclear phagocyte morphologyabnormal macrophage morphologyabnormal alveolar macrophage morphologyabnormal Kupffer cell morphologyabnormal macrophage derived foam cell morphology +abnormal macrophage differentiationabnormal metallophilic macrophage morphologyabnormal microglial cell morphology [MP:0000136] (134 genotypes, 136 annotations)abnormal microglial cell differentiationdecreased microglial cell numbermicrogliosisabnormal osteoclast morphology +abnormal peritoneal macrophage morphologyabnormal perivascular macrophage morphologyabnormal spleen marginal zone macrophage morphologydecreased macrophage cell number +increased macrophage cell number +immune system phenotypeabnormal immune system morphologyabnormal immune system cell morphologyabnormal professional antigen presenting cell morphologyabnormal macrophage morphologyabnormal alveolar macrophage morphologyabnormal Kupffer cell morphologyabnormal macrophage derived foam cell morphology +abnormal macrophage differentiationabnormal metallophilic macrophage morphologyabnormal microglial cell morphology [MP:0000136] (134 genotypes, 136 annotations)abnormal microglial cell differentiationdecreased microglial cell numbermicrogliosisabnormal osteoclast morphology +abnormal peritoneal macrophage morphologyabnormal perivascular macrophage morphologyabnormal spleen marginal zone macrophage morphologydecreased macrophage cell number +increased macrophage cell number +nervous system phenotypeabnormal nervous system morphologyabnormal glial cell morphologyabnormal CNS glial cell morphologyabnormal astrocyte morphology +abnormal microglial cell morphology [MP:0000136] (134 genotypes, 136 annotations)abnormal microglial cell differentiationdecreased microglial cell numbermicrogliosisabnormal Muller cell morphologyabnormal oligodendrocyte morphology +abnormal radial glial cell morphologyectopic Bergmann glia cellsMouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc |
||
|
Citing These Resources Funding Information Warranty Disclaimer & Copyright Notice Send questions and comments to User Support. |
last database update 05/08/2013 MGI 5.13 |
|
|
|
||
Analysis Tools