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Gene Ontology Browser
Term Detail
GO term:lens fiber cell differentiation
Synonym: lens fibre cell differentiation
GO id:GO:0070306
Definition:The process in which a relatively unspecialized cell acquires specialized features of a lens fiber cell, any of the elongated, tightly packed cells that make up the bulk of the mature lens in the camera-type eye. The cytoplasm of a lens fiber cell is devoid of most intracellular organelles including the cell nucleus, and contains primarily crystallins, a group of water-soluble proteins expressed in vary large quantities.
Number of paths to term: 16

is-adenotes an 'is-a' relationship
part-ofdenotes a 'part-of' relationship
regulatesdenotes a 'regulates' relationship
positively-regulatesdenotes a 'positively-regulates' relationship
negatively-regulatesdenotes a 'negatively-regulates' relationship


Gene_Ontology
        is-abiological_process
                is-acellular process
                        is-asingle-organism cellular process
                                is-acellular developmental process
                                        is-acell differentiation
                                                is-aepithelial cell differentiation
                                                        is-acolumnar/cuboidal epithelial cell differentiation +
                                                        is-acumulus cell differentiation +
                                                        is-aendothelial cell differentiation +
                                                        is-aepidermal cell differentiation +
                                                        part-ofepithelial cell development +
                                                        is-aepithelial cell differentiation involved in embryonic placenta development +
                                                        is-aepithelial cell differentiation involved in kidney development +
                                                        is-aepithelial cell differentiation involved in prostate gland development +
                                                        is-aepithelial cell differentiation involved in salivary gland development +
                                                        part-ofepithelial cell fate commitment +
                                                        is-agranulosa cell differentiation +
                                                        is-ahepatoblast differentiation
                                                        is-ahepatocyte differentiation +
                                                        is-aleading edge cell differentiation +
                                                        is-alens fiber cell differentiation [GO:0070306] (23 genes, 28 annotations)
                                                                part-oflens fiber cell development +
                                                                part-oflens fiber cell fate commitment
                                                                negatively-regulatesnegative regulation of lens fiber cell differentiation
                                                                positively-regulatespositive regulation of lens fiber cell differentiation
                                                                regulatesregulation of lens fiber cell differentiation +
                                                        is-alung epithelial cell differentiation +
                                                        is-aMalpighian tubule principal cell differentiation
                                                        is-aMalpighian tubule stellate cell differentiation
                                                        is-amammary gland epithelial cell differentiation +
                                                        is-amulti-ciliated epithelial cell differentiation
                                                        negatively-regulatesnegative regulation of epithelial cell differentiation +
                                                        is-aodontoblast differentiation +
                                                        is-apolarized epithelial cell differentiation +
                                                        positively-regulatespositive regulation of epithelial cell differentiation +
                                                        regulatesregulation of epithelial cell differentiation +
                                                        is-arespiratory basal cell differentiation
                                                        is-aSertoli cell differentiation +
                                                        is-aureter epithelial cell differentiation


Gene_Ontology
        is-abiological_process
                is-adevelopmental process
                        is-aanatomical structure development
                                is-alens development in camera-type eye
                                        part-oflens epithelial cell proliferation +
                                        part-oflens fiber cell differentiation [GO:0070306] (23 genes, 28 annotations)
                                                part-oflens fiber cell development +
                                                part-oflens fiber cell fate commitment
                                                negatively-regulatesnegative regulation of lens fiber cell differentiation
                                                positively-regulatespositive regulation of lens fiber cell differentiation
                                                regulatesregulation of lens fiber cell differentiation +
                                        part-oflens morphogenesis in camera-type eye +


Gene_Ontology
        is-abiological_process
                is-adevelopmental process
                        is-aanatomical structure development
                                is-aorgan development
                                        is-asensory organ development
                                                is-aeye development
                                                        is-acamera-type eye development
                                                                part-oflens development in camera-type eye
                                                                        part-oflens epithelial cell proliferation +
                                                                        part-oflens fiber cell differentiation [GO:0070306] (23 genes, 28 annotations)
                                                                                part-oflens fiber cell development +
                                                                                part-oflens fiber cell fate commitment
                                                                                negatively-regulatesnegative regulation of lens fiber cell differentiation
                                                                                positively-regulatespositive regulation of lens fiber cell differentiation
                                                                                regulatesregulation of lens fiber cell differentiation +
                                                                        part-oflens morphogenesis in camera-type eye +


Gene_Ontology
        is-abiological_process
                is-adevelopmental process
                        is-aanatomical structure development
                                is-asystem development
                                        part-oforgan development
                                                is-asensory organ development
                                                        is-aeye development
                                                                is-acamera-type eye development
                                                                        part-oflens development in camera-type eye
                                                                                part-oflens epithelial cell proliferation +
                                                                                part-oflens fiber cell differentiation [GO:0070306] (23 genes, 28 annotations)
                                                                                        part-oflens fiber cell development +
                                                                                        part-oflens fiber cell fate commitment
                                                                                        negatively-regulatesnegative regulation of lens fiber cell differentiation
                                                                                        positively-regulatespositive regulation of lens fiber cell differentiation
                                                                                        regulatesregulation of lens fiber cell differentiation +
                                                                                part-oflens morphogenesis in camera-type eye +


Gene_Ontology
        is-abiological_process
                is-adevelopmental process
                        is-aanatomical structure development
                                is-atissue development
                                        is-aepithelium development
                                                part-ofepithelial cell differentiation
                                                        is-acolumnar/cuboidal epithelial cell differentiation +
                                                        is-acumulus cell differentiation +
                                                        is-aendothelial cell differentiation +
                                                        is-aepidermal cell differentiation +
                                                        part-ofepithelial cell development +
                                                        is-aepithelial cell differentiation involved in embryonic placenta development +
                                                        is-aepithelial cell differentiation involved in kidney development +
                                                        is-aepithelial cell differentiation involved in prostate gland development +
                                                        is-aepithelial cell differentiation involved in salivary gland development +
                                                        part-ofepithelial cell fate commitment +
                                                        is-agranulosa cell differentiation +
                                                        is-ahepatoblast differentiation
                                                        is-ahepatocyte differentiation +
                                                        is-aleading edge cell differentiation +
                                                        is-alens fiber cell differentiation [GO:0070306] (23 genes, 28 annotations)
                                                                part-oflens fiber cell development +
                                                                part-oflens fiber cell fate commitment
                                                                negatively-regulatesnegative regulation of lens fiber cell differentiation
                                                                positively-regulatespositive regulation of lens fiber cell differentiation
                                                                regulatesregulation of lens fiber cell differentiation +
                                                        is-alung epithelial cell differentiation +
                                                        is-aMalpighian tubule principal cell differentiation
                                                        is-aMalpighian tubule stellate cell differentiation
                                                        is-amammary gland epithelial cell differentiation +
                                                        is-amulti-ciliated epithelial cell differentiation
                                                        negatively-regulatesnegative regulation of epithelial cell differentiation +
                                                        is-aodontoblast differentiation +
                                                        is-apolarized epithelial cell differentiation +
                                                        positively-regulatespositive regulation of epithelial cell differentiation +
                                                        regulatesregulation of epithelial cell differentiation +
                                                        is-arespiratory basal cell differentiation
                                                        is-aSertoli cell differentiation +
                                                        is-aureter epithelial cell differentiation


Gene_Ontology
        is-abiological_process
                is-adevelopmental process
                        is-asingle-organism developmental process
                                is-acellular developmental process
                                        is-acell differentiation
                                                is-aepithelial cell differentiation
                                                        is-acolumnar/cuboidal epithelial cell differentiation +
                                                        is-acumulus cell differentiation +
                                                        is-aendothelial cell differentiation +
                                                        is-aepidermal cell differentiation +
                                                        part-ofepithelial cell development +
                                                        is-aepithelial cell differentiation involved in embryonic placenta development +
                                                        is-aepithelial cell differentiation involved in kidney development +
                                                        is-aepithelial cell differentiation involved in prostate gland development +
                                                        is-aepithelial cell differentiation involved in salivary gland development +
                                                        part-ofepithelial cell fate commitment +
                                                        is-agranulosa cell differentiation +
                                                        is-ahepatoblast differentiation
                                                        is-ahepatocyte differentiation +
                                                        is-aleading edge cell differentiation +
                                                        is-alens fiber cell differentiation [GO:0070306] (23 genes, 28 annotations)
                                                                part-oflens fiber cell development +
                                                                part-oflens fiber cell fate commitment
                                                                negatively-regulatesnegative regulation of lens fiber cell differentiation
                                                                positively-regulatespositive regulation of lens fiber cell differentiation
                                                                regulatesregulation of lens fiber cell differentiation +
                                                        is-alung epithelial cell differentiation +
                                                        is-aMalpighian tubule principal cell differentiation
                                                        is-aMalpighian tubule stellate cell differentiation
                                                        is-amammary gland epithelial cell differentiation +
                                                        is-amulti-ciliated epithelial cell differentiation
                                                        negatively-regulatesnegative regulation of epithelial cell differentiation +
                                                        is-aodontoblast differentiation +
                                                        is-apolarized epithelial cell differentiation +
                                                        positively-regulatespositive regulation of epithelial cell differentiation +
                                                        regulatesregulation of epithelial cell differentiation +
                                                        is-arespiratory basal cell differentiation
                                                        is-aSertoli cell differentiation +
                                                        is-aureter epithelial cell differentiation


Gene_Ontology
        is-abiological_process
                is-adevelopmental process
                        is-asingle-organism developmental process
                                is-alens development in camera-type eye
                                        part-oflens epithelial cell proliferation +
                                        part-oflens fiber cell differentiation [GO:0070306] (23 genes, 28 annotations)
                                                part-oflens fiber cell development +
                                                part-oflens fiber cell fate commitment
                                                negatively-regulatesnegative regulation of lens fiber cell differentiation
                                                positively-regulatespositive regulation of lens fiber cell differentiation
                                                regulatesregulation of lens fiber cell differentiation +
                                        part-oflens morphogenesis in camera-type eye +


Gene_Ontology
        is-abiological_process
                is-adevelopmental process
                        is-asingle-organism developmental process
                                is-amulticellular organismal development
                                        part-ofsystem development
                                                part-oforgan development
                                                        is-asensory organ development
                                                                is-aeye development
                                                                        is-acamera-type eye development
                                                                                part-oflens development in camera-type eye
                                                                                        part-oflens epithelial cell proliferation +
                                                                                        part-oflens fiber cell differentiation [GO:0070306] (23 genes, 28 annotations)
                                                                                                part-oflens fiber cell development +
                                                                                                part-oflens fiber cell fate commitment
                                                                                                negatively-regulatesnegative regulation of lens fiber cell differentiation
                                                                                                positively-regulatespositive regulation of lens fiber cell differentiation
                                                                                                regulatesregulation of lens fiber cell differentiation +
                                                                                        part-oflens morphogenesis in camera-type eye +


Gene_Ontology
        is-abiological_process
                is-adevelopmental process
                        is-asingle-organism developmental process
                                is-asensory organ development
                                        is-aeye development
                                                is-acamera-type eye development
                                                        part-oflens development in camera-type eye
                                                                part-oflens epithelial cell proliferation +
                                                                part-oflens fiber cell differentiation [GO:0070306] (23 genes, 28 annotations)
                                                                        part-oflens fiber cell development +
                                                                        part-oflens fiber cell fate commitment
                                                                        negatively-regulatesnegative regulation of lens fiber cell differentiation
                                                                        positively-regulatespositive regulation of lens fiber cell differentiation
                                                                        regulatesregulation of lens fiber cell differentiation +
                                                                part-oflens morphogenesis in camera-type eye +


Gene_Ontology
        is-abiological_process
                is-amulticellular organismal process
                        is-asingle-multicellular organism process
                                is-amulticellular organismal development
                                        part-ofsystem development
                                                part-oforgan development
                                                        is-asensory organ development
                                                                is-aeye development
                                                                        is-acamera-type eye development
                                                                                part-oflens development in camera-type eye
                                                                                        part-oflens epithelial cell proliferation +
                                                                                        part-oflens fiber cell differentiation [GO:0070306] (23 genes, 28 annotations)
                                                                                                part-oflens fiber cell development +
                                                                                                part-oflens fiber cell fate commitment
                                                                                                negatively-regulatesnegative regulation of lens fiber cell differentiation
                                                                                                positively-regulatespositive regulation of lens fiber cell differentiation
                                                                                                regulatesregulation of lens fiber cell differentiation +
                                                                                        part-oflens morphogenesis in camera-type eye +


Gene_Ontology
        is-abiological_process
                is-asingle-organism process
                        is-asingle-multicellular organism process
                                is-amulticellular organismal development
                                        part-ofsystem development
                                                part-oforgan development
                                                        is-asensory organ development
                                                                is-aeye development
                                                                        is-acamera-type eye development
                                                                                part-oflens development in camera-type eye
                                                                                        part-oflens epithelial cell proliferation +
                                                                                        part-oflens fiber cell differentiation [GO:0070306] (23 genes, 28 annotations)
                                                                                                part-oflens fiber cell development +
                                                                                                part-oflens fiber cell fate commitment
                                                                                                negatively-regulatesnegative regulation of lens fiber cell differentiation
                                                                                                positively-regulatespositive regulation of lens fiber cell differentiation
                                                                                                regulatesregulation of lens fiber cell differentiation +
                                                                                        part-oflens morphogenesis in camera-type eye +


Gene_Ontology
        is-abiological_process
                is-asingle-organism process
                        is-asingle-organism cellular process
                                is-acellular developmental process
                                        is-acell differentiation
                                                is-aepithelial cell differentiation
                                                        is-acolumnar/cuboidal epithelial cell differentiation +
                                                        is-acumulus cell differentiation +
                                                        is-aendothelial cell differentiation +
                                                        is-aepidermal cell differentiation +
                                                        part-ofepithelial cell development +
                                                        is-aepithelial cell differentiation involved in embryonic placenta development +
                                                        is-aepithelial cell differentiation involved in kidney development +
                                                        is-aepithelial cell differentiation involved in prostate gland development +
                                                        is-aepithelial cell differentiation involved in salivary gland development +
                                                        part-ofepithelial cell fate commitment +
                                                        is-agranulosa cell differentiation +
                                                        is-ahepatoblast differentiation
                                                        is-ahepatocyte differentiation +
                                                        is-aleading edge cell differentiation +
                                                        is-alens fiber cell differentiation [GO:0070306] (23 genes, 28 annotations)
                                                                part-oflens fiber cell development +
                                                                part-oflens fiber cell fate commitment
                                                                negatively-regulatesnegative regulation of lens fiber cell differentiation
                                                                positively-regulatespositive regulation of lens fiber cell differentiation
                                                                regulatesregulation of lens fiber cell differentiation +
                                                        is-alung epithelial cell differentiation +
                                                        is-aMalpighian tubule principal cell differentiation
                                                        is-aMalpighian tubule stellate cell differentiation
                                                        is-amammary gland epithelial cell differentiation +
                                                        is-amulti-ciliated epithelial cell differentiation
                                                        negatively-regulatesnegative regulation of epithelial cell differentiation +
                                                        is-aodontoblast differentiation +
                                                        is-apolarized epithelial cell differentiation +
                                                        positively-regulatespositive regulation of epithelial cell differentiation +
                                                        regulatesregulation of epithelial cell differentiation +
                                                        is-arespiratory basal cell differentiation
                                                        is-aSertoli cell differentiation +
                                                        is-aureter epithelial cell differentiation


Gene_Ontology
        is-abiological_process
                is-asingle-organism process
                        is-asingle-organism developmental process
                                is-acellular developmental process
                                        is-acell differentiation
                                                is-aepithelial cell differentiation
                                                        is-acolumnar/cuboidal epithelial cell differentiation +
                                                        is-acumulus cell differentiation +
                                                        is-aendothelial cell differentiation +
                                                        is-aepidermal cell differentiation +
                                                        part-ofepithelial cell development +
                                                        is-aepithelial cell differentiation involved in embryonic placenta development +
                                                        is-aepithelial cell differentiation involved in kidney development +
                                                        is-aepithelial cell differentiation involved in prostate gland development +
                                                        is-aepithelial cell differentiation involved in salivary gland development +
                                                        part-ofepithelial cell fate commitment +
                                                        is-agranulosa cell differentiation +
                                                        is-ahepatoblast differentiation
                                                        is-ahepatocyte differentiation +
                                                        is-aleading edge cell differentiation +
                                                        is-alens fiber cell differentiation [GO:0070306] (23 genes, 28 annotations)
                                                                part-oflens fiber cell development +
                                                                part-oflens fiber cell fate commitment
                                                                negatively-regulatesnegative regulation of lens fiber cell differentiation
                                                                positively-regulatespositive regulation of lens fiber cell differentiation
                                                                regulatesregulation of lens fiber cell differentiation +
                                                        is-alung epithelial cell differentiation +
                                                        is-aMalpighian tubule principal cell differentiation
                                                        is-aMalpighian tubule stellate cell differentiation
                                                        is-amammary gland epithelial cell differentiation +
                                                        is-amulti-ciliated epithelial cell differentiation
                                                        negatively-regulatesnegative regulation of epithelial cell differentiation +
                                                        is-aodontoblast differentiation +
                                                        is-apolarized epithelial cell differentiation +
                                                        positively-regulatespositive regulation of epithelial cell differentiation +
                                                        regulatesregulation of epithelial cell differentiation +
                                                        is-arespiratory basal cell differentiation
                                                        is-aSertoli cell differentiation +
                                                        is-aureter epithelial cell differentiation


Gene_Ontology
        is-abiological_process
                is-asingle-organism process
                        is-asingle-organism developmental process
                                is-alens development in camera-type eye
                                        part-oflens epithelial cell proliferation +
                                        part-oflens fiber cell differentiation [GO:0070306] (23 genes, 28 annotations)
                                                part-oflens fiber cell development +
                                                part-oflens fiber cell fate commitment
                                                negatively-regulatesnegative regulation of lens fiber cell differentiation
                                                positively-regulatespositive regulation of lens fiber cell differentiation
                                                regulatesregulation of lens fiber cell differentiation +
                                        part-oflens morphogenesis in camera-type eye +


Gene_Ontology
        is-abiological_process
                is-asingle-organism process
                        is-asingle-organism developmental process
                                is-amulticellular organismal development
                                        part-ofsystem development
                                                part-oforgan development
                                                        is-asensory organ development
                                                                is-aeye development
                                                                        is-acamera-type eye development
                                                                                part-oflens development in camera-type eye
                                                                                        part-oflens epithelial cell proliferation +
                                                                                        part-oflens fiber cell differentiation [GO:0070306] (23 genes, 28 annotations)
                                                                                                part-oflens fiber cell development +
                                                                                                part-oflens fiber cell fate commitment
                                                                                                negatively-regulatesnegative regulation of lens fiber cell differentiation
                                                                                                positively-regulatespositive regulation of lens fiber cell differentiation
                                                                                                regulatesregulation of lens fiber cell differentiation +
                                                                                        part-oflens morphogenesis in camera-type eye +


Gene_Ontology
        is-abiological_process
                is-asingle-organism process
                        is-asingle-organism developmental process
                                is-asensory organ development
                                        is-aeye development
                                                is-acamera-type eye development
                                                        part-oflens development in camera-type eye
                                                                part-oflens epithelial cell proliferation +
                                                                part-oflens fiber cell differentiation [GO:0070306] (23 genes, 28 annotations)
                                                                        part-oflens fiber cell development +
                                                                        part-oflens fiber cell fate commitment
                                                                        negatively-regulatesnegative regulation of lens fiber cell differentiation
                                                                        positively-regulatespositive regulation of lens fiber cell differentiation
                                                                        regulatesregulation of lens fiber cell differentiation +
                                                                part-oflens morphogenesis in camera-type eye +


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last database update
12/09/2014
MGI 5.20
The Jackson Laboratory