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Gene Ontology Browser
Term Detail
GO term:lens fiber cell differentiation
Synonym: lens fibre cell differentiation
GO id:GO:0070306
Definition:The process in which a relatively unspecialized cell acquires specialized features of a lens fiber cell, any of the elongated, tightly packed cells that make up the bulk of the mature lens in the camera-type eye. The cytoplasm of a lens fiber cell is devoid of most intracellular organelles including the cell nucleus, and contains primarily crystallins, a group of water-soluble proteins expressed in vary large quantities.
Number of paths to term: 13

is-adenotes an 'is-a' relationship
part-ofdenotes a 'part-of' relationship
regulatesdenotes a 'regulates' relationship
positively-regulatesdenotes a 'positively-regulates' relationship
negatively-regulatesdenotes a 'negatively-regulates' relationship


Gene_Ontology
        is-abiological_process
                is-acellular process
                        is-asingle-organism cellular process
                                is-acellular developmental process
                                        is-acell differentiation
                                                is-aangioblast cell differentiation
                                                is-aanther wall tapetum cell differentiation +
                                                is-aantipodal cell differentiation +
                                                is-acardiocyte differentiation +
                                                part-ofcell development +
                                                is-acell differentiation in hindbrain +
                                                is-acell differentiation in spinal cord +
                                                is-acell differentiation involved in embryonic placenta development +
                                                is-acell differentiation involved in kidney development +
                                                is-acell differentiation involved in salivary gland development +
                                                is-acell differentiation involved in spore germination
                                                part-ofcell fate commitment +
                                                is-achondroblast differentiation
                                                is-achondrocyte differentiation +
                                                is-achorionic trophoblast cell differentiation +
                                                is-acollenchyma cell differentiation
                                                is-acompound eye cone cell differentiation +
                                                is-acorticotropin hormone secreting cell differentiation +
                                                is-acumulus cell differentiation +
                                                is-aectodermal cell differentiation +
                                                is-aembryo sac central cell differentiation +
                                                is-aembryo sac egg cell differentiation +
                                                is-aendodermal cell differentiation +
                                                is-aenteroendocrine cell differentiation
                                                is-aepidermal cell differentiation +
                                                is-aepithelial cell differentiation +
                                                is-afat cell differentiation +
                                                is-afoam cell differentiation +
                                                is-afollicular dendritic cell differentiation
                                                part-ofG1 to G0 transition involved in cell differentiation
                                                is-agenerative cell differentiation
                                                is-aglial cell differentiation +
                                                is-agranulosa cell differentiation +
                                                is-aguard mother cell differentiation
                                                is-ahemangioblast cell differentiation
                                                is-ahematopoietic progenitor cell differentiation +
                                                is-ahemocyte differentiation +
                                                is-ahepatic stellate cell differentiation
                                                is-ahepatocyte differentiation +
                                                is-aheterocyst differentiation
                                                is-ahypothalamus cell differentiation +
                                                is-ainner cell mass cell differentiation +
                                                is-alens fiber cell differentiation [GO:0070306] (18 genes, 21 annotations)
                                                        part-oflens fiber cell development +
                                                        part-oflens fiber cell fate commitment
                                                is-aleukocyte differentiation +
                                                is-aLeydig cell differentiation
                                                is-alung cell differentiation +
                                                is-aMalpighian tubule tip cell differentiation
                                                is-amesenchymal cell differentiation +
                                                is-amesodermal cell differentiation +
                                                is-amicrosporocyte differentiation
                                                is-amuscle cell differentiation +
                                                is-amyeloid cell differentiation +
                                                is-amystery cell differentiation
                                                negatively-regulatesnegative regulation of cell differentiation +
                                                is-aneuroblast differentiation +
                                                is-aneuroendocrine cell differentiation +
                                                is-aneuroepithelial cell differentiation +
                                                is-aneurogenesis +
                                                is-aneuromast mantle cell differentiation +
                                                is-aneuromast support cell differentiation +
                                                is-aneuron differentiation +
                                                is-anotochord cell differentiation +
                                                is-aodontoblast differentiation +
                                                is-aoenocyte differentiation +
                                                is-aolfactory bulb interneuron differentiation +
                                                is-aoocyte differentiation +
                                                is-aosteoblast differentiation +
                                                is-apancreatic A cell differentiation +
                                                is-apancreatic D cell differentiation +
                                                is-apancreatic epsilon cell differentiation +
                                                is-apancreatic PP cell differentiation +
                                                is-aparenchymal cell differentiation +
                                                is-apigment cell differentiation +
                                                is-apigment cell precursor differentiation
                                                is-apollen sperm cell differentiation
                                                positively-regulatespositive regulation of cell differentiation +
                                                is-aprolactin secreting cell differentiation +
                                                is-aradial glial cell differentiation +
                                                regulatesregulation of cell differentiation +
                                                is-arenal filtration cell differentiation +
                                                is-arhombomere cell differentiation
                                                is-asclerenchyma cell differentiation
                                                is-aSertoli cell differentiation +
                                                is-asieve cell differentiation
                                                is-asomatotropin secreting cell differentiation +
                                                is-asorocarp spore cell differentiation +
                                                is-asorocarp stalk cell differentiation +
                                                is-aspermatid differentiation +
                                                is-asporocyte differentiation
                                                is-asporulation resulting in formation of a cellular spore +
                                                is-astem cell differentiation +
                                                is-asynergid differentiation +
                                                is-atendon cell differentiation +
                                                is-athyroid-stimulating hormone-secreting cell differentiation +
                                                is-atransdifferentiation
                                                is-atrophectodermal cell differentiation +
                                                is-atype B pancreatic cell differentiation +
                                                is-avasculogenesis +
                                                is-avegetative cell differentiation
                                                is-axylem vessel member cell differentiation


Gene_Ontology
        is-abiological_process
                is-adevelopmental process
                        is-aanatomical structure development
                                is-alens development in camera-type eye
                                        part-oflens epithelial cell proliferation +
                                        part-oflens fiber cell differentiation [GO:0070306] (18 genes, 21 annotations)
                                                part-oflens fiber cell development +
                                                part-oflens fiber cell fate commitment
                                        part-oflens morphogenesis in camera-type eye +


Gene_Ontology
        is-abiological_process
                is-adevelopmental process
                        is-aanatomical structure development
                                is-aorgan development
                                        is-asensory organ development
                                                is-aeye development
                                                        is-acamera-type eye development
                                                                part-oflens development in camera-type eye
                                                                        part-oflens epithelial cell proliferation +
                                                                        part-oflens fiber cell differentiation [GO:0070306] (18 genes, 21 annotations)
                                                                                part-oflens fiber cell development +
                                                                                part-oflens fiber cell fate commitment
                                                                        part-oflens morphogenesis in camera-type eye +


Gene_Ontology
        is-abiological_process
                is-adevelopmental process
                        is-aanatomical structure development
                                is-asystem development
                                        part-oforgan development
                                                is-asensory organ development
                                                        is-aeye development
                                                                is-acamera-type eye development
                                                                        part-oflens development in camera-type eye
                                                                                part-oflens epithelial cell proliferation +
                                                                                part-oflens fiber cell differentiation [GO:0070306] (18 genes, 21 annotations)
                                                                                        part-oflens fiber cell development +
                                                                                        part-oflens fiber cell fate commitment
                                                                                part-oflens morphogenesis in camera-type eye +


Gene_Ontology
        is-abiological_process
                is-adevelopmental process
                        is-acellular developmental process
                                is-acell differentiation
                                        is-aangioblast cell differentiation
                                        is-aanther wall tapetum cell differentiation +
                                        is-aantipodal cell differentiation +
                                        is-acardiocyte differentiation +
                                        part-ofcell development +
                                        is-acell differentiation in hindbrain +
                                        is-acell differentiation in spinal cord +
                                        is-acell differentiation involved in embryonic placenta development +
                                        is-acell differentiation involved in kidney development +
                                        is-acell differentiation involved in salivary gland development +
                                        is-acell differentiation involved in spore germination
                                        part-ofcell fate commitment +
                                        is-achondroblast differentiation
                                        is-achondrocyte differentiation +
                                        is-achorionic trophoblast cell differentiation +
                                        is-acollenchyma cell differentiation
                                        is-acompound eye cone cell differentiation +
                                        is-acorticotropin hormone secreting cell differentiation +
                                        is-acumulus cell differentiation +
                                        is-aectodermal cell differentiation +
                                        is-aembryo sac central cell differentiation +
                                        is-aembryo sac egg cell differentiation +
                                        is-aendodermal cell differentiation +
                                        is-aenteroendocrine cell differentiation
                                        is-aepidermal cell differentiation +
                                        is-aepithelial cell differentiation +
                                        is-afat cell differentiation +
                                        is-afoam cell differentiation +
                                        is-afollicular dendritic cell differentiation
                                        part-ofG1 to G0 transition involved in cell differentiation
                                        is-agenerative cell differentiation
                                        is-aglial cell differentiation +
                                        is-agranulosa cell differentiation +
                                        is-aguard mother cell differentiation
                                        is-ahemangioblast cell differentiation
                                        is-ahematopoietic progenitor cell differentiation +
                                        is-ahemocyte differentiation +
                                        is-ahepatic stellate cell differentiation
                                        is-ahepatocyte differentiation +
                                        is-aheterocyst differentiation
                                        is-ahypothalamus cell differentiation +
                                        is-ainner cell mass cell differentiation +
                                        is-alens fiber cell differentiation [GO:0070306] (18 genes, 21 annotations)
                                                part-oflens fiber cell development +
                                                part-oflens fiber cell fate commitment
                                        is-aleukocyte differentiation +
                                        is-aLeydig cell differentiation
                                        is-alung cell differentiation +
                                        is-aMalpighian tubule tip cell differentiation
                                        is-amesenchymal cell differentiation +
                                        is-amesodermal cell differentiation +
                                        is-amicrosporocyte differentiation
                                        is-amuscle cell differentiation +
                                        is-amyeloid cell differentiation +
                                        is-amystery cell differentiation
                                        negatively-regulatesnegative regulation of cell differentiation +
                                        is-aneuroblast differentiation +
                                        is-aneuroendocrine cell differentiation +
                                        is-aneuroepithelial cell differentiation +
                                        is-aneurogenesis +
                                        is-aneuromast mantle cell differentiation +
                                        is-aneuromast support cell differentiation +
                                        is-aneuron differentiation +
                                        is-anotochord cell differentiation +
                                        is-aodontoblast differentiation +
                                        is-aoenocyte differentiation +
                                        is-aolfactory bulb interneuron differentiation +
                                        is-aoocyte differentiation +
                                        is-aosteoblast differentiation +
                                        is-apancreatic A cell differentiation +
                                        is-apancreatic D cell differentiation +
                                        is-apancreatic epsilon cell differentiation +
                                        is-apancreatic PP cell differentiation +
                                        is-aparenchymal cell differentiation +
                                        is-apigment cell differentiation +
                                        is-apigment cell precursor differentiation
                                        is-apollen sperm cell differentiation
                                        positively-regulatespositive regulation of cell differentiation +
                                        is-aprolactin secreting cell differentiation +
                                        is-aradial glial cell differentiation +
                                        regulatesregulation of cell differentiation +
                                        is-arenal filtration cell differentiation +
                                        is-arhombomere cell differentiation
                                        is-asclerenchyma cell differentiation
                                        is-aSertoli cell differentiation +
                                        is-asieve cell differentiation
                                        is-asomatotropin secreting cell differentiation +
                                        is-asorocarp spore cell differentiation +
                                        is-asorocarp stalk cell differentiation +
                                        is-aspermatid differentiation +
                                        is-asporocyte differentiation
                                        is-asporulation resulting in formation of a cellular spore +
                                        is-astem cell differentiation +
                                        is-asynergid differentiation +
                                        is-atendon cell differentiation +
                                        is-athyroid-stimulating hormone-secreting cell differentiation +
                                        is-atransdifferentiation
                                        is-atrophectodermal cell differentiation +
                                        is-atype B pancreatic cell differentiation +
                                        is-avasculogenesis +
                                        is-avegetative cell differentiation
                                        is-axylem vessel member cell differentiation


Gene_Ontology
        is-abiological_process
                is-adevelopmental process
                        is-amulticellular organismal development
                                part-ofsystem development
                                        part-oforgan development
                                                is-asensory organ development
                                                        is-aeye development
                                                                is-acamera-type eye development
                                                                        part-oflens development in camera-type eye
                                                                                part-oflens epithelial cell proliferation +
                                                                                part-oflens fiber cell differentiation [GO:0070306] (18 genes, 21 annotations)
                                                                                        part-oflens fiber cell development +
                                                                                        part-oflens fiber cell fate commitment
                                                                                part-oflens morphogenesis in camera-type eye +


Gene_Ontology
        is-abiological_process
                is-adevelopmental process
                        is-asingle-organism developmental process
                                is-alens development in camera-type eye
                                        part-oflens epithelial cell proliferation +
                                        part-oflens fiber cell differentiation [GO:0070306] (18 genes, 21 annotations)
                                                part-oflens fiber cell development +
                                                part-oflens fiber cell fate commitment
                                        part-oflens morphogenesis in camera-type eye +


Gene_Ontology
        is-abiological_process
                is-adevelopmental process
                        is-asingle-organism developmental process
                                is-asensory organ development
                                        is-aeye development
                                                is-acamera-type eye development
                                                        part-oflens development in camera-type eye
                                                                part-oflens epithelial cell proliferation +
                                                                part-oflens fiber cell differentiation [GO:0070306] (18 genes, 21 annotations)
                                                                        part-oflens fiber cell development +
                                                                        part-oflens fiber cell fate commitment
                                                                part-oflens morphogenesis in camera-type eye +


Gene_Ontology
        is-abiological_process
                is-amulticellular organismal process
                        is-asingle-multicellular organism process
                                is-amulticellular organismal development
                                        part-ofsystem development
                                                part-oforgan development
                                                        is-asensory organ development
                                                                is-aeye development
                                                                        is-acamera-type eye development
                                                                                part-oflens development in camera-type eye
                                                                                        part-oflens epithelial cell proliferation +
                                                                                        part-oflens fiber cell differentiation [GO:0070306] (18 genes, 21 annotations)
                                                                                                part-oflens fiber cell development +
                                                                                                part-oflens fiber cell fate commitment
                                                                                        part-oflens morphogenesis in camera-type eye +


Gene_Ontology
        is-abiological_process
                is-asingle-organism process
                        is-asingle-multicellular organism process
                                is-amulticellular organismal development
                                        part-ofsystem development
                                                part-oforgan development
                                                        is-asensory organ development
                                                                is-aeye development
                                                                        is-acamera-type eye development
                                                                                part-oflens development in camera-type eye
                                                                                        part-oflens epithelial cell proliferation +
                                                                                        part-oflens fiber cell differentiation [GO:0070306] (18 genes, 21 annotations)
                                                                                                part-oflens fiber cell development +
                                                                                                part-oflens fiber cell fate commitment
                                                                                        part-oflens morphogenesis in camera-type eye +


Gene_Ontology
        is-abiological_process
                is-asingle-organism process
                        is-asingle-organism cellular process
                                is-acellular developmental process
                                        is-acell differentiation
                                                is-aangioblast cell differentiation
                                                is-aanther wall tapetum cell differentiation +
                                                is-aantipodal cell differentiation +
                                                is-acardiocyte differentiation +
                                                part-ofcell development +
                                                is-acell differentiation in hindbrain +
                                                is-acell differentiation in spinal cord +
                                                is-acell differentiation involved in embryonic placenta development +
                                                is-acell differentiation involved in kidney development +
                                                is-acell differentiation involved in salivary gland development +
                                                is-acell differentiation involved in spore germination
                                                part-ofcell fate commitment +
                                                is-achondroblast differentiation
                                                is-achondrocyte differentiation +
                                                is-achorionic trophoblast cell differentiation +
                                                is-acollenchyma cell differentiation
                                                is-acompound eye cone cell differentiation +
                                                is-acorticotropin hormone secreting cell differentiation +
                                                is-acumulus cell differentiation +
                                                is-aectodermal cell differentiation +
                                                is-aembryo sac central cell differentiation +
                                                is-aembryo sac egg cell differentiation +
                                                is-aendodermal cell differentiation +
                                                is-aenteroendocrine cell differentiation
                                                is-aepidermal cell differentiation +
                                                is-aepithelial cell differentiation +
                                                is-afat cell differentiation +
                                                is-afoam cell differentiation +
                                                is-afollicular dendritic cell differentiation
                                                part-ofG1 to G0 transition involved in cell differentiation
                                                is-agenerative cell differentiation
                                                is-aglial cell differentiation +
                                                is-agranulosa cell differentiation +
                                                is-aguard mother cell differentiation
                                                is-ahemangioblast cell differentiation
                                                is-ahematopoietic progenitor cell differentiation +
                                                is-ahemocyte differentiation +
                                                is-ahepatic stellate cell differentiation
                                                is-ahepatocyte differentiation +
                                                is-aheterocyst differentiation
                                                is-ahypothalamus cell differentiation +
                                                is-ainner cell mass cell differentiation +
                                                is-alens fiber cell differentiation [GO:0070306] (18 genes, 21 annotations)
                                                        part-oflens fiber cell development +
                                                        part-oflens fiber cell fate commitment
                                                is-aleukocyte differentiation +
                                                is-aLeydig cell differentiation
                                                is-alung cell differentiation +
                                                is-aMalpighian tubule tip cell differentiation
                                                is-amesenchymal cell differentiation +
                                                is-amesodermal cell differentiation +
                                                is-amicrosporocyte differentiation
                                                is-amuscle cell differentiation +
                                                is-amyeloid cell differentiation +
                                                is-amystery cell differentiation
                                                negatively-regulatesnegative regulation of cell differentiation +
                                                is-aneuroblast differentiation +
                                                is-aneuroendocrine cell differentiation +
                                                is-aneuroepithelial cell differentiation +
                                                is-aneurogenesis +
                                                is-aneuromast mantle cell differentiation +
                                                is-aneuromast support cell differentiation +
                                                is-aneuron differentiation +
                                                is-anotochord cell differentiation +
                                                is-aodontoblast differentiation +
                                                is-aoenocyte differentiation +
                                                is-aolfactory bulb interneuron differentiation +
                                                is-aoocyte differentiation +
                                                is-aosteoblast differentiation +
                                                is-apancreatic A cell differentiation +
                                                is-apancreatic D cell differentiation +
                                                is-apancreatic epsilon cell differentiation +
                                                is-apancreatic PP cell differentiation +
                                                is-aparenchymal cell differentiation +
                                                is-apigment cell differentiation +
                                                is-apigment cell precursor differentiation
                                                is-apollen sperm cell differentiation
                                                positively-regulatespositive regulation of cell differentiation +
                                                is-aprolactin secreting cell differentiation +
                                                is-aradial glial cell differentiation +
                                                regulatesregulation of cell differentiation +
                                                is-arenal filtration cell differentiation +
                                                is-arhombomere cell differentiation
                                                is-asclerenchyma cell differentiation
                                                is-aSertoli cell differentiation +
                                                is-asieve cell differentiation
                                                is-asomatotropin secreting cell differentiation +
                                                is-asorocarp spore cell differentiation +
                                                is-asorocarp stalk cell differentiation +
                                                is-aspermatid differentiation +
                                                is-asporocyte differentiation
                                                is-asporulation resulting in formation of a cellular spore +
                                                is-astem cell differentiation +
                                                is-asynergid differentiation +
                                                is-atendon cell differentiation +
                                                is-athyroid-stimulating hormone-secreting cell differentiation +
                                                is-atransdifferentiation
                                                is-atrophectodermal cell differentiation +
                                                is-atype B pancreatic cell differentiation +
                                                is-avasculogenesis +
                                                is-avegetative cell differentiation
                                                is-axylem vessel member cell differentiation


Gene_Ontology
        is-abiological_process
                is-asingle-organism process
                        is-asingle-organism developmental process
                                is-alens development in camera-type eye
                                        part-oflens epithelial cell proliferation +
                                        part-oflens fiber cell differentiation [GO:0070306] (18 genes, 21 annotations)
                                                part-oflens fiber cell development +
                                                part-oflens fiber cell fate commitment
                                        part-oflens morphogenesis in camera-type eye +


Gene_Ontology
        is-abiological_process
                is-asingle-organism process
                        is-asingle-organism developmental process
                                is-asensory organ development
                                        is-aeye development
                                                is-acamera-type eye development
                                                        part-oflens development in camera-type eye
                                                                part-oflens epithelial cell proliferation +
                                                                part-oflens fiber cell differentiation [GO:0070306] (18 genes, 21 annotations)
                                                                        part-oflens fiber cell development +
                                                                        part-oflens fiber cell fate commitment
                                                                part-oflens morphogenesis in camera-type eye +


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
05/08/2013
MGI 5.13
The Jackson Laboratory